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M K Wu Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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L de Kock Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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L S Conwell Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada
Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada
Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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C J R Stewart Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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B R King Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada
Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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C S Choong Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada
Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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K Hussain Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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N Sabbaghian Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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I J MacRae Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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M R Fabian Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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W D Foulkes Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada
Department of Medical Genetics, Lady Davis Institute Jewish General Hospital, McGill University, Department Endocrinology and Diabetes, Lady Cilento Children's Hospital, School of Medicine, University of Queensland, Queensland Children's Medical Research Institute, Department of Histopathology, King Edward Memorial Hospital, John Hunter Children's Hospital, School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, School of Paediatrics and Child Health, University of Western Australia, Department of Paediatric Endocrinology and Diabetes, Princess Margaret Hospital for Children, Child and Adolescent Health Service, Genetics and Epigenetics in Health and Disease Genetics and Genomic Medicine Programme UCL Institute of Child Health Great Ormond Street Hospital for Children, The Scripps Research Institute, Departments of Oncology and Experimental Medicine, McGill University, Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

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B and C). The best described function of DICER1 protein is to remove the terminal loop from pre-miRNA to produce mature microRNAs (miRNAs). Mature miRNAs are called 5p miRNAs if they originate from the 5 prime end or 3p miRNAs if they originate from

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Maria Denaro Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Clara Ugolini Department of Laboratory Medicine Section of Pathology Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy

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Anello Marcello Poma Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Nicla Borrelli Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Piaggi National Institute of Diabetes and Digestive and Kidney Diseases Phoenix, Arizona, USA

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Massimo Chiarugi Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Miccoli Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy

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Fulvio Basolo Department of Surgical Pathology Medical, Molecular and Critical Area, University of Pisa, Pisa, Italy

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Perren A Moch H Komminoth P Nikiforov YE Nikiforova MN 2013 Comprehensive MicroRNA expression profiling identifies novel markers in follicular variant of papillary thyroid carcinoma . Thyroid 23 1383 – 1389 . ( doi:10.1089/thy

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Annunziata Di Domenico Institute of Pathology, University of Bern, Bern, Switzerland
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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Tabea Wiedmer Institute of Pathology, University of Bern, Bern, Switzerland
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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Ilaria Marinoni Institute of Pathology, University of Bern, Bern, Switzerland

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Aurel Perren Institute of Pathology, University of Bern, Bern, Switzerland

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profiles will be the basis for better indication of specific epigenetic modifiers for future specific treatments. MicroRNA (miRNA) expression profiles Pancreatic NET There are only few studies investigating the effect of microRNAs (miRNA) in

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V H M Tsang Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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T Dwight Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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D E Benn Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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G Y Meyer-Rochow Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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A J Gill Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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M Sywak Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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S Sidhu Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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D Veivers Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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C M Sue Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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B G Robinson Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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R J Clifton-Bligh Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research
Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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N R Parker Cancer Genetics Laboratory, Department of Endocrinology, Department of Surgery, Department of Anatomical Pathology, Cancer Diagnosis and Oncology Group, Department of Endocrine and Oncology Surgery, Neurogenetics Research Laboratory, Department of ENT Surgery, Department of Neurology, Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research

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hypoxic rather than a kinase activation phenotype. There has been increasing interest in the role of microRNA (miRNA) in tumour development. These non-coding RNAs, 20–22 nucleotides in length, regulate gene expression via binding to 3′UTRs of their related

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Yu-Ling Tai Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

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Chun-Jung Lin Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Tsai-Kun Li Department and Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

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Tang-Long Shen Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

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Jer-Tsong Hsieh Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Benjamin P C Chen Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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D Yang TL Bucay N Sekhon K Majid S Shahryari V Dahiya R Tanaka Y Saini S 2018 microRNA-1246 is an exosomal biomarker for aggressive prostate cancer . Cancer Research 78 1833 – 1844 . ( https://doi.org/10.1158/0008-5472.CAN-17

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Aura D Herrera-Martínez Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Leo J Hofland Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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María A Gálvez Moreno Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Justo P Castaño Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Wouter W de Herder Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Richard A Feelders Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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’, ‘germline’, ‘somatic’, ‘alternative lengthening of telomeres’, ‘whole-genome sequencing’, ‘chromatin remodeling’, ‘DNA repair’, ‘cell-free DNA’, ‘RNA markers’, ‘microRNAs’, ‘somatostatin receptor expression’, ‘O-6-methylguanine-DNA methyltransferase’, ‘mTOR

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Belinda van Zyl Hunter Medical Research Institute, Newcastle, New South Wales, Australia
School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, New South Wales, Australia

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Denise Tang Hunter Medical Research Institute, Newcastle, New South Wales, Australia
School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, New South Wales, Australia

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Nikola A Bowden Hunter Medical Research Institute, Newcastle, New South Wales, Australia
School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, New South Wales, Australia

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HGSOC-specific microRNAs, DNA methylation and histone acetylation patterns. Figure 3 The role of DNA repair deficiencies in high-grade serous ovarian cancer (HGSOC) platinum chemotherapy resistance. (A) NER-and HR-proficient (NER+ and HR

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Haleh Vosgha Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

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Armin Ariana Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

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Robert Anthony Smith Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia
Genomics Research Centre, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia

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Alfred King-yin Lam Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

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its profound metastatic and invasive characteristics ( Guo et al . 2014 ). Therefore, this study investigated the simultaneous suppression of angiogenesis, proliferation and invasion of this aggressive tumour through microRNA expression, which could

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Feng Wu Department of Endocrinology, The Third Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Fuxingzi Li Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Xiao Lin Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Feng Xu Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Rong-Rong Cui Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Jia-Yu Zhong Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Ting Zhu Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Su-Kang Shan Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Xiao-Bo Liao Department of Cardiovascular Surgery, the Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Ling-Qing Yuan Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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Zhao-Hui Mo Department of Endocrinology, The Third Xiang-Ya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

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their exosomes . Oncogene 34 3640 – 3650 . ( https://doi.org/10.1038/onc.2014.300 ) 10.1038/onc.2014.300 25263437 Cui RR Li SJ Liu LJ Yi L Liang QH Zhu X Liu GY Liu Y Wu SS Liao XB , et al . 2012 MicroRNA-204 regulates vascular smooth muscle

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Zhe Wang Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Ke Ma Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Steffie Pitts Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Yulan Cheng Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Xi Liu Department of Pathology, The First Affiliated Hospital of Xi’ an Jiaotong University, Xi’ an, Shaanxi, China

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Xiquan Ke Department of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China

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Samuel Kovaka Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

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Hassan Ashktorab Cancer Center, Howard University School of Medicine, Washington, District of Columbia, USA

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Duane T Smoot Department of Medicine, Meharry Medical College, Nashville, Tennessee, USA

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Michael Schatz Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

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Zhirong Wang Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

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Stephen J Meltzer Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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−ΔΔCt ) method and normalized against the threshold cycle (Ct) of GAPDH or β-actin. For detecting expression levels of miRNA, cDNA samples were amplified using TaqMan MicroRNA Assays (Applied Biosystems), and RNU6B was used as a reference gene

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