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E Patterson
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R Webb
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A Weisbrod
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B Bian
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M He
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L Zhang
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A K Holloway Endocrine Oncology Section, Gladstone Institutes, Program in Reproductive and Adult Endocrinology, NIH/NCI/Surgery Branch, National Cancer Institute, NIH, Hatfield Clinical Research Center, Room 4‐5952, 10 Center Drive, Bethesda, Maryland 20892, USA

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R Krishna
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N Nilubol
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K Pacak Endocrine Oncology Section, Gladstone Institutes, Program in Reproductive and Adult Endocrinology, NIH/NCI/Surgery Branch, National Cancer Institute, NIH, Hatfield Clinical Research Center, Room 4‐5952, 10 Center Drive, Bethesda, Maryland 20892, USA

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E Kebebew
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( Zarnegar et al . 2006 ). The prevalence of malignant pheochromocytoma is 2.5–40%, and the overall survival rate is <50% at 5 years ( Zarnegar et al . 2006 ). Currently, there are no reliable histologic or molecular markers for distinguishing between

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0308
Volume/Issue:
Volume 19: Issue 2
Free access
Sonia Cheng Department of Pathology, Servicio de Endocrinología, Department of Medicine, University Health Network and the Ontario Cancer Institute, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada M5G 2C4
Department of Pathology, Servicio de Endocrinología, Department of Medicine, University Health Network and the Ontario Cancer Institute, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada M5G 2C4

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Wei Liu Department of Pathology, Servicio de Endocrinología, Department of Medicine, University Health Network and the Ontario Cancer Institute, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada M5G 2C4

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Moises Mercado Department of Pathology, Servicio de Endocrinología, Department of Medicine, University Health Network and the Ontario Cancer Institute, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada M5G 2C4

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Shereen Ezzat Department of Pathology, Servicio de Endocrinología, Department of Medicine, University Health Network and the Ontario Cancer Institute, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada M5G 2C4

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Sylvia L Asa Department of Pathology, Servicio de Endocrinología, Department of Medicine, University Health Network and the Ontario Cancer Institute, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada M5G 2C4

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human liver diseases: utility as molecular markers for hepatocellular carcinoma . Journal of Hepatology 32 612 – 617 . Kondo T Ezzat S Asa SL 2006 Pathogenetic mechanisms in thyroid follicular-cell neoplasia . Nature Reviews. Cancer 6

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0002
Volume/Issue:
Volume 16: Issue 2
Free access
B Wängberg Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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A Khorram-Manesh Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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S Jansson Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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B Nilsson Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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O Nilsson Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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C E Jakobsson Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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S Lindstedt Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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A Odén Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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H Ahlman Surgery, Clinical Chemistry, Department of Mathemathical Sciences, Departments of

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ACC is an aggressive tumour disease with clinical course that can be difficult to predict also in patients with radically resected low-stage tumours ( Vassilopoulou-Sellin & Schultz 2001 ). Besides tumour staging and Weiss score, several molecular

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0190
Volume/Issue:
Volume 17: Issue 1
Free access
Sofia K Gruvberger-Saal
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Heather E Cunliffe
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Kristen M Carr
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Ingrid A Hedenfalk
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, prognosis, and treatment sensitivity, as well as traditional histopathological parameters. This review will focus on how the application of microarray-based technologies in the investigations of molecular markers has evolved from descriptive biological

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01246
Volume/Issue:
Volume 13: Issue 4
Free access
Aura D Herrera-Martínez Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Leo J Hofland Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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María A Gálvez Moreno Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Justo P Castaño Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain

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Wouter W de Herder Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Richard A Feelders Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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effect of the mTOR inhibitor everolimus and red arrows the effect of the tyrosine kinase inhibitor sunitinib. Molecular markers are presented in blue. Response to sunitinib has been related to decreased SDF1, IL-8, VEGFR 2-3, CD14 monocytes expressing

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0354
Volume/Issue:
Volume 26: Issue 3
Free access
M Niedziela Department of Pediatric Endocrinology and Diabetes, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60–572 Poznan, Poland

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’ of thyroiditis ( Loh et al. 1999 ). The question arises as to whether the thyroiditis preceded the nodule or vice versa. New data coming from molecular studies of the BRAF mutations, the molecular marker of PTC, indicate that the

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.00882
Volume/Issue:
Volume 13: Issue 2
Free access
Robert C Smallridge Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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Laura A Marlow Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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John A Copland Division of Endocrinology, Department of Cancer Biology, Department of Internal Medicine

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), the potential to integrate a-CGH results with histopathology and other molecular markers, and to relate the laboratory findings with patient diagnosis, prognosis, and therapy, will bring an individualized approach to cancer therapy in clinical practice

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0154
Volume/Issue:
Volume 16: Issue 1
Free access
Chiara Villa Department of Neuropathology, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France
Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France

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Bertrand Baussart Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Neurosurgery, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France

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Guillaume Assié Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin APHP, Paris, France

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Gerald Raverot Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est" Hospices Civils de Lyon, Bron, France
Lyon 1 University, Villeurbanne, France
Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon, Lyon, France

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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molecular profiling in the classification of PitNETs Considerable progress has been made in the molecular characterisation of PitNETs but unlike other tumour types, the use of molecular markers has not entered diagnostic practice. In this respect, the

Article Type:
Review Article
Collections:
Mini Reviews in Endocrine Related Cancer
DOI:
https://doi.org/10.1530/ERC-23-0021
Volume/Issue:
Volume 30: Issue 8
Free access
Adriana Albani Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Luis Gustavo Perez-Rivas Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Sicheng Tang Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Julia Simon Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Kristin Elisabeth Lucia Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Paula Colón-Bolea Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Jochen Schopohl Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Sigrun Roeber Center for Neuropathology and Prion Research, LMU Munich, Munich, Germany

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Michael Buchfelder Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany

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Roman Rotermund Department of Neurosurgery, Universitätskrankenhaus Hamburg-Eppendorf, Hamburg, Germany

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Jörg Flitsch Department of Neurosurgery, Universitätskrankenhaus Hamburg-Eppendorf, Hamburg, Germany

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Jun Thorsteinsdottir Neurochirurgische Klinik und Poliklinik, LMU Klinikum, Munich, Germany

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Jochen Herms Center for Neuropathology and Prion Research, LMU Munich, Munich, Germany

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Günter Stalla Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany
Medicover Neuroendocrinology, Munich, Germany

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Martin Reincke Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Marily Theodoropoulou Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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normalization under pasireotide treatment ( Colao et al. 2012 , Witek et al. 2018 ). Recently, a consensus statement has highlighted the potential of USP8 mutational status as a molecular marker of pasireotide response ( Fleseriu et al. 2021 ). Our

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0088
Volume/Issue:
Volume 29: Issue 8
Open access
Simona Falletta Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Stefano Partelli Pancreatic Surgery Unit, Pancreas Translational and Research Institute, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy

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Corrado Rubini Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

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Dominik Nann Institut fur Pathologie, University of Bern, Bern, Switzerland

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Andrea Doria Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

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Ilaria Marinoni Institut fur Pathologie, University of Bern, Bern, Switzerland

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Vanessa Polenta Pancreatic Surgery Unit, Pancreas Translational and Research Institute, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy

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Carmelina Di Pasquale Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Ettore degli Uberti Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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Aurel Perren Institut fur Pathologie, University of Bern, Bern, Switzerland

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Massimo Falconi Pancreatic Surgery Unit, Pancreas Translational and Research Institute, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy

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Maria Chiara Zatelli Department of Medical Science, Section of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy

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including a very heterogeneous group of NET of different origin. Therefore, the results obtained by Benslama and coworkers may not reflect P-NET behavior ( Benslama et al . 2016 ). Besides putative molecular markers, we also investigated whether P

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0329
Volume/Issue:
Volume 23: Issue 11
Free access