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papillary carcinoma from benign thyroid nodules. Journal of Clinical Endocrinology and Metabolism 89 3214 –3223. Finley DJ , Zhu B, Barden CB & Fahey TJ III 2004b Discrimination of benign and malignant thyroid nodules by
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Introduction Rearrangements of the protooncogene RET resulting in its constitutive activation are believed to play a causative role in the pathogenesis of a significant proportion of papillary carcinomas of the thyroid (PTC
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Division of Endocrinology and Metabolism, Department of Surgery, Department of Hospital Pathology, Medical Life Sciences, Department of Internal Medicine
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), Warthin-like ( n =2), Cribriform ( n =2) variants, and NA ( n =124). b Out of 247 papillary carcinomas with BRAF mutation, 245 (99.2%) have BRAF V600E mutation and two have BRAF fusion mutation. Impact of BRAF V600E allele percentage on
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frequently performed, and serous papillary carcinoma was the most common tumor subtype (data not shown). To evaluate the prognostic value of long-term Mel treatment associated or not to EtOH consumption, we first investigated non-treated animals bearing OC
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, papillary thyroid carcinoma, and Hashimoto's thyroiditis: a stem cell hypothesis of papillary carcinoma oncogenesis . Human Pathology 35 465 – 473 . doi:10.1016/j.humpath.2003.10.027 . Caserta TM Kommagani R Yuan Z Robbins DJ Mercer CA
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suppressor genes in parathyroid neoplasia respectively. Of the two up-regulated genes, miR-222 is clustered (<10 kb) with miR-221. miR-221 has been found to be over-expressed in human thyroid papillary carcinomas together with miR-222. Over-expression of
Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
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Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
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Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
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Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine Laennec, UMR 664, Lyon F-69372, France
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hyperplasia and, later, solid tumor variants of papillary carcinomas. All mice were housed in a conventional animal facility with a 12h light:12h darkness cycle; they were fed with standard laboratory chow (Safe Animal Food and Engineering, Augy, France) and
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). Additionally, interobserver variation in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma has been described in the literature ( Elsheikh et al. 2008 , Liu et al. 2019 ), and the lack of a standard
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from different histotypes of human thyroid tumors and in papillary carcinoma tissues ( Ulisse et al. 2006 a ). Since the TACC3 protein represents a substrate of Aurora-A kinase and, to the best of our knowledge, the expression of the three TACC
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and papillary carcinoma cell lines displayed an invasive phenotype and a robust response to EGF (10 ng/ml), with 1.3- to 7-fold increases in invasion observed (Figs 2 and 3 ). FTC-238 cells displayed low baseline invasiveness but were highly sensitive