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Kellen Cristine Tjioe Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil
Laboratory of Immunopharmacology, Department of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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Diovana Melo Cardoso Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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Sandra Helena Penha Oliveira Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil
Laboratory of Immunopharmacology, Department of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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Daniel Galera Bernabé Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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Bhutia SK 2018 Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma . Cell Proliferation 51 e12411. ( https://doi.org/10.1111/cpr.12411 ) Nilsson MB Sun

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Irasema Mendieta Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Gabriel Rodríguez-Gómez Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Bertha Rueda-Zarazúa Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Julia Rodríguez-Castelán Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Winniberg Álvarez-León Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Evangelina Delgado-González Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Brenda Anguiano Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Olivia Vázquez-Martínez Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Mauricio Díaz-Muñoz Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Carmen Aceves Instituto de Neurobiología, UNAM-Juriquilla, Querétaro, México

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Chemistry 281 19762 – 19771 . ( https://doi.org/10.1074/jbc.M600746200 ) Singh P Godbole M Rao G Annarao S Mitra K Roy R Ingle A Agarwal G Tiwari S 2011 Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone

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Lisa Zhang Endocrine Oncology Section, Surgery Branch, National Cancer Institute, NIH, HHS, Clinical Research Center, Building 10‐CRC, Room 3‐3940, 10 Center Drive, MSC 1201, Bethesda, Maryland 20892, USA

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Reza Rahbari Endocrine Oncology Section, Surgery Branch, National Cancer Institute, NIH, HHS, Clinical Research Center, Building 10‐CRC, Room 3‐3940, 10 Center Drive, MSC 1201, Bethesda, Maryland 20892, USA

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Mei He Endocrine Oncology Section, Surgery Branch, National Cancer Institute, NIH, HHS, Clinical Research Center, Building 10‐CRC, Room 3‐3940, 10 Center Drive, MSC 1201, Bethesda, Maryland 20892, USA

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Electron Kebebew Endocrine Oncology Section, Surgery Branch, National Cancer Institute, NIH, HHS, Clinical Research Center, Building 10‐CRC, Room 3‐3940, 10 Center Drive, MSC 1201, Bethesda, Maryland 20892, USA

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thyroid carcinoma. Treatment outcome and prognostic factors . Cancer 103 1330 – 1335 . doi:10.1002/cncr.20936 . Lista P Straface E Brunelleschi S Franconi F Malorni W 2011 On the role of autophagy in human diseases: a gender perspective

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Frédérique Végran Molecular Biology Laboratory, Biostatistics and epidemiological unit, EA 4184, Centre Georges‐François Leclerc, IFR Santé‐STIC, 1 Rue du Professeur Marion, 21079 Dijon Cedex, France

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Romain Boidot Molecular Biology Laboratory, Biostatistics and epidemiological unit, EA 4184, Centre Georges‐François Leclerc, IFR Santé‐STIC, 1 Rue du Professeur Marion, 21079 Dijon Cedex, France

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Franck Bonnetain Molecular Biology Laboratory, Biostatistics and epidemiological unit, EA 4184, Centre Georges‐François Leclerc, IFR Santé‐STIC, 1 Rue du Professeur Marion, 21079 Dijon Cedex, France

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Muriel Cadouot Molecular Biology Laboratory, Biostatistics and epidemiological unit, EA 4184, Centre Georges‐François Leclerc, IFR Santé‐STIC, 1 Rue du Professeur Marion, 21079 Dijon Cedex, France

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Sandy Chevrier Molecular Biology Laboratory, Biostatistics and epidemiological unit, EA 4184, Centre Georges‐François Leclerc, IFR Santé‐STIC, 1 Rue du Professeur Marion, 21079 Dijon Cedex, France

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Sarab Lizard-Nacol Molecular Biology Laboratory, Biostatistics and epidemiological unit, EA 4184, Centre Georges‐François Leclerc, IFR Santé‐STIC, 1 Rue du Professeur Marion, 21079 Dijon Cedex, France

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noted in bold. Discussion Survivin, an apoptosis inhibitor protein, is highly expressed in human cancers, including breast cancer, and is considered as a new therapeutic target. Recently, a critical role for Survivin in the control of autophagy was also

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Antti Kyrönlahti Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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Marjut Kauppinen Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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Essi Lind Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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Leila Unkila-Kallio Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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Ralf Butzow Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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Juha Klefström Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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David B Wilson Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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Mikko Anttonen Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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Markku Heikinheimo Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland
Children's Hospital, University of Helsinki, Program for Women's Health, Department of Obstetrics and Gynecology, Department of Pathology, Institute of Biomedicine and Research Program in Genome-Scale Biology, Department of Pediatrics, PO Box 22 (Stenbäckinkatu 11), 00014 Helsinki, Finland

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regulates cardiac BCL2 gene expression in vitro and in vivo . FASEB Journal 20 800 – 802 . Kobayashi S Volden P Timm D Mao K Xu X Liang Q 2009 Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death

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Vladislava Paharkova-Vatchkova Division of Pediatric Endocrinology, David Geffen School of Medicine at UCLA, Mattel Children's Hospital, 10833 Le Conte Avenue, MDCC 22-315, Los Angeles, California 90095, USA

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Kuk-Wha Lee Division of Pediatric Endocrinology, David Geffen School of Medicine at UCLA, Mattel Children's Hospital, 10833 Le Conte Avenue, MDCC 22-315, Los Angeles, California 90095, USA

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. Cancer Research 56 1545 – 1550 . Heath-Engel HM Chang NC Shore GC 2008 The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family . Oncogene 27 6419 – 6433 . Hetz CA 2007 ER stress signaling and the BCL

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Carolyn Algire
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Lilian Amrein Department of Experimental Medicine, Lady Davis Institute for Medical Research, Department of Oncology, McGill University, 1110 Pins Avenue West, Montréal, Québec, Canada H3A 1A3

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Mahvash Zakikhani Department of Experimental Medicine, Lady Davis Institute for Medical Research, Department of Oncology, McGill University, 1110 Pins Avenue West, Montréal, Québec, Canada H3A 1A3

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Lawrence Panasci Department of Experimental Medicine, Lady Davis Institute for Medical Research, Department of Oncology, McGill University, 1110 Pins Avenue West, Montréal, Québec, Canada H3A 1A3

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Michael Pollak Department of Experimental Medicine, Lady Davis Institute for Medical Research, Department of Oncology, McGill University, 1110 Pins Avenue West, Montréal, Québec, Canada H3A 1A3

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maintaining cellular energy supply required an AMPK-dependent and p53-dependent switch to autophagy in vivo and glycolysis in vitro . In the absence of functional p53, this switch is impaired and leads to an energy deficit and growth inhibition. In the

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D Dworakowska Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK
Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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E Wlodek Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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C A Leontiou Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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S Igreja Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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M Cakir Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK
Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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M Teng Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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N Prodromou Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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M I Góth Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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S Grozinsky-Glasberg Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK
Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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M Gueorguiev Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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B Kola Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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M Korbonits Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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A B Grossman Barts and the London School of Medicine, Department of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Internal Medicine, Institute of Endocrinology and Metabolism, Centre for Endocrinology, London, UK

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R Aggarwal BB Kondo Y 2007 Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways . Molecular

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Ales Vicha
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David Taieb Department of Pediatric Hematology and Oncology, Service Central de Biophysique et de Médecine Nucléaire, Département d'Oncologie Moléculaire, Program in Reproductive and Adult Endocrinology, 2nd Medical School, Charles University and University Hospital Motol, Prague, Czech Republic
Department of Pediatric Hematology and Oncology, Service Central de Biophysique et de Médecine Nucléaire, Département d'Oncologie Moléculaire, Program in Reproductive and Adult Endocrinology, 2nd Medical School, Charles University and University Hospital Motol, Prague, Czech Republic

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Karel Pacak Department of Pediatric Hematology and Oncology, Service Central de Biophysique et de Médecine Nucléaire, Département d'Oncologie Moléculaire, Program in Reproductive and Adult Endocrinology, 2nd Medical School, Charles University and University Hospital Motol, Prague, Czech Republic

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Medicine 360 1361 – 1362 . (author reply 1362) ( doi:10.1056/NEJMc090088 ). Eng CH Abraham RT 2010 Glutaminolysis yields a metabolic by-product that stimulates autophagy . Autophagy 6 968 – 970 . ( doi:10.4161/auto.6.7.13082 ). Eng C

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S Kato Division of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, Chile

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M F Liberona Division of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, Chile

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J Cerda-Infante Department of Hematology and Oncology, Faculty of Medicine, PUC, Santiago, Chile
Department of Cellular and Molecular, Faculty of Biological Sciences, PUC, Santiago, Chile

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M Sánchez Department of Hematology and Oncology, Faculty of Medicine, PUC, Santiago, Chile

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J Henríquez Department of Hematology and Oncology, Faculty of Medicine, PUC, Santiago, Chile

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C Bizama Department of Pathology, Faculty of Medicine, PUC, Santiago, Chile

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M L Bravo Department of Physiological Sciences, Faculty of Biological Sciences, PUC, Santiago, Chile
Millennium Institute on Immunology and Immunotherapy, PUC, Santiago, Chile

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P Gonzalez Department of Physiological Sciences, Faculty of Biological Sciences, PUC, Santiago, Chile

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R Gejman Department of Pathology, Faculty of Medicine, PUC, Santiago, Chile

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J Brañes Division of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, Chile

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K García Division of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, Chile

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C Ibañez Department of Hematology and Oncology, Faculty of Medicine, PUC, Santiago, Chile
Millennium Institute on Immunology and Immunotherapy, PUC, Santiago, Chile

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G I Owen Department of Physiological Sciences, Faculty of Biological Sciences, PUC, Santiago, Chile
Millennium Institute on Immunology and Immunotherapy, PUC, Santiago, Chile

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J C Roa Department of Pathology, Faculty of Medicine, PUC, Santiago, Chile
Millennium Institute on Immunology and Immunotherapy, PUC, Santiago, Chile

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V Montecinos Department of Hematology and Oncology, Faculty of Medicine, PUC, Santiago, Chile

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M A Cuello Division of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile (PUC), Santiago, Chile

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mevalonate and cholesterol synthesis and blocking protein prenylation by downstream depletion of FPP and GGP ( Berndt et al . 2011 ). Treating mut-TP53 HGS-ovC cell lines with increasing concentrations of statins induces autophagy, cell death and drug

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