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Tullio Florio Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Federica Barbieri Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Renato Spaziante Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Gianluigi Zona Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Leo J Hofland Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Peter M van Koetsveld Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Richard A Feelders Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Günter K Stalla Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Marily Theodoropoulou Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Michael D Culler Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Jesse Dong Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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John E Taylor Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Jacques-Pierre Moreau Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Alexandru Saveanu Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Ginette Gunz Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Henry Dufour Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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Philippe Jaquet Departments of, Oncology, Neurology, Department of Internal Medicine, Department of Endocrinology, IPSEN, Departments of Endocrinology, Biology and Genetics

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to be more effective than each single agonist in the growth hormone (GH)-secreting adenomas, partially responding to octreotide ( Jaquet et al . 2005 ). Thus, we investigated the efficacy of one of these dopamine–somatostatin chimeric compounds

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P J Jenkins
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S Khalaf
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W Ogunkolade
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K McCarthy
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T David
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R E Hands
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D Davies
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S A Bustin
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. While serum levels of IGF-I, which are regulated by growth hormone (GH), are generally considered to be a positive risk factor for the development of colorectal cancer, the role of IGFBP-3 appears less clear. Some studies suggest it exerts a protective

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Pedro Marques Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Sayka Barry Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Eivind Carlsen Department of Pathology, STHF, Skien, Norway

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David Collier Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Amy Ronaldson Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Sherine Awad Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Neil Dorward The National Hospital for Neurology and Neurosurgery, UCLH, NHS Trust, London, UK

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Joan Grieve The National Hospital for Neurology and Neurosurgery, UCLH, NHS Trust, London, UK

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Nigel Mendoza Department of Neurosurgery, Charing Cross Hospital, Imperial College, London, UK

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Samiul Muquit Department of Neurosurgery, Derriford Hospital, Plymouth, UK

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Ashley B Grossman Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Frances Balkwill Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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.078006 ) Castro CP Giacomini D Nagashima AC Onofri C Graciarena M Kobayashi K Paez-Pereda M Renner U Stalla GK Arzt E 2003 Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of

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Paraskevi Xekouki Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UK

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Emily J Lodge Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Endocrinology and Diabetes, King’s College London, London, UK

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Jakob Matschke Institute of Neuropathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

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Alice Santambrogio Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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John R Apps Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK

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Ariane Sharif Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France

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Thomas S Jacques Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK

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Simon Aylwin Department of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UK

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Vincent Prevot Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France

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Ran Li Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

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Jörg Flitsch Department of Neurosurgery, Hamburg University Medical Center, Hamburg, Germany

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Stefan R Bornstein Department of Endocrinology and Diabetes, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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Marily Theodoropoulou Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Cynthia L Andoniadou Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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signalling cascade in pituitary gland pathophysiology. Mice deficient for Lats1 ( Lats1 − / − ) present with hyperplasia of the anterior pituitary lobe, but reduced secretion of hormones such as LH, PRL and GH ( St John et al. 1999 ). We

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W Solarek Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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A M Czarnecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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B Escudier Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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Z F Bielecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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F Lian Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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C Szczylik Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

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-releasing hormone antagonist (GH-RH) and somatostatin analog on the proliferation of the human RCC cell line Caki-1 (isolated from skin metastasis) in vitro and in vivo . They showed that both GH-RH antagonist and somatostatin analog inhibit the growth of the

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Elena Sabini Department of Pathology, Johns Hopkins Hospital, School of Medicine, Baltimore, Maryland, USA
Department of Pathology, Johns Hopkins Hospital, School of Medicine, Baltimore, Maryland, USA

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Amna Khan Department of Pathology, Johns Hopkins Hospital, School of Medicine, Baltimore, Maryland, USA
Department of Pathology, Johns Hopkins Hospital, School of Medicine, Baltimore, Maryland, USA

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Patrizio Caturegli Department of Pathology, Johns Hopkins Hospital, School of Medicine, Baltimore, Maryland, USA
Department of Pathology, Johns Hopkins Hospital, School of Medicine, Baltimore, Maryland, USA

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quantities that cause a clinical syndrome, just as Cushing disease arises from the hypersecretion of adrenocorticotropic hormone (ACTH) or acromegaly from the hypersecretion of growth hormone (GH) ( Asa et al. 2022 ). Other adenomas do not produce increased

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Gregory Kaltsas
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Ioannis I Androulakis
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Wouter W de Herder Endocrine Unit, Department of Pathophysiology, National University of Athens, Department of Internal Medicine, Sector of Endocrinology, Department of Endocrinology, St Bartholomew's Hospital, Mikras Asias 75, 11527 Athens, Greece

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Ashley B Grossman Endocrine Unit, Department of Pathophysiology, National University of Athens, Department of Internal Medicine, Sector of Endocrinology, Department of Endocrinology, St Bartholomew's Hospital, Mikras Asias 75, 11527 Athens, Greece

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cell of origin ( Keffer 1996 ). The term ‘paraneoplastic syndromes’ (PNSs) is used to denote an array of symptom complexes that are manifested systemically as the result of the production of hormones, growth factors, cytokines and/or other substances by

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Chiara Villa Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France
Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Maria Stefania Lagonigro Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Flavia Magri Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Maria Koziak Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Marie-Lise Jaffrain-Rea Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France
Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Raja Brauner Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Jerome Bouligand Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Marie Pierre Junier Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Federico Di Rocco Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Christian Sainte-Rose Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Albert Beckers Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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François Xavier Roux Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Adrian F Daly Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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Luca Chiovato Unit of Neuropathology, Unit of Internal Medicine and Endocrinology, Unit of Neurosurgery, Department of Experimental Medicine, Neuromed Institute, Unit of Pediatric Endocrinology, University of Paris‐Sud, Department of Pediatric Neurosurgery, Department of Endocrinology, INSERM U984 Laboratory of Glial Plasticity, Centre Hospitalier Sainte Anne, University of Paris Descartes, 1 Rue Cabanis, 75014 Paris, France

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supported by the lack of growth disorders and other clinical symptoms or signs attributable to somatotrope hypersecretion. Owing to this lack of suggestive symptoms or signs in advance of emergency presentation, the standard hormonal workup (including

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Cindy M Staka Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, UK

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Robert I Nicholson Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, UK

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Julia M W Gee Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, UK

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exquisitely low residual steroid hormone levels now appear sufficient to support tumour cell growth. Indeed, Santen et al. (2004) have shown oestradiol concentrations as low as 10 −14 M maximally stimulate growth of their ER+ long-term oestrogen deprived

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Meng-Lei Zhu Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA

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Natasha Kyprianou Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA

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transforming growth factor-beta-induced apoptosis in hormone-sensitive prostate cancer cells . Endocrinology 142 2419 – 2426 . Bruckheimer EM Kyprianou N 2002 BCL-2 antagonizes the combined apoptotic effect of transforming growth factor-beta and

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