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Francesco Caiazza School of Medicine, University College Dublin, Ireland
Centre for Colorectal Disease, St. Vincent’s University Hospital, Dublin, Ireland

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Alyson Murray School of Medicine, University College Dublin, Ireland

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Stephen F Madden Population Health Sciences, Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland

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Naoise C Synnott School of Medicine, University College Dublin, Ireland

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Elizabeth J Ryan School of Medicine, University College Dublin, Ireland
Centre for Colorectal Disease, St. Vincent’s University Hospital, Dublin, Ireland

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Norma O’Donovan National Institute for Cellular Biotechnology (NICB), Dublin City University, Dublin, Ireland

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John Crown School of Medicine, University College Dublin, Ireland
Department of Medical Oncology, St. Vincent’s University Hospital, Dublin, Ireland

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Michael J Duffy School of Medicine, University College Dublin, Ireland
UCD Clinical Research Centre, St. Vincent's University Hospital, Dublin, Ireland

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surviving fraction was determined by comparing the plating efficiency of treated vs control wells. The total colony area was calculated for each biological replicate by averaging the area of all colonies in replicate wells. Cell invasion assays Cell

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Ravi Kumar Dutta Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Jenny Welander Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Michael Brauckhoff Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Martin Walz Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Piero Alesina Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Thomas Arnesen Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Peter Söderkvist Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Oliver Gimm Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden

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Iuri Martin Goemann Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre

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Mirian Romitti Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre

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Erika L Souza Meyer Department of Internal Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

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Simone Magagnin Wajner Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre

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Ana Luiza Maia Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre

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expression in tumor cells influence cell proliferation, differentiation, survival and invasion in a variety of neoplasms in a cell type-specific manner ( Lin et al . 2008 , Dentice et al . 2009 , Pinto et al . 2011 ). The function of THs and TRs in

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Fateme Salehi Laboratory Medicine, Neurosurgery, Department of Laboratory Medicine and Pathology, Departments of

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Kalman Kovacs Laboratory Medicine, Neurosurgery, Department of Laboratory Medicine and Pathology, Departments of

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Bernd W Scheithauer Laboratory Medicine, Neurosurgery, Department of Laboratory Medicine and Pathology, Departments of

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Ricardo V Lloyd Laboratory Medicine, Neurosurgery, Department of Laboratory Medicine and Pathology, Departments of

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Michael Cusimano Laboratory Medicine, Neurosurgery, Department of Laboratory Medicine and Pathology, Departments of

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cancers, its expression is associated with tumor invasiveness and aggressive behavior ( Heaney et al . 2000 , Boelaert et al . 2003 a ). PTTG is implicated in several normal cellular processes, including DNA damage repair, apoptosis, and angiogenesis

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Isadora Ramos-Andrade Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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João Moraes Redox Biology Laboratory Programa de Pesquisa em Farmacologia e Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

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Renata Machado Brandão-Costa Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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Simone Vargas da Silva Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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Antônio de Souza Serviço de Cirurgia Plástica, Departamento de Cirurgia Geral, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

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César da Silva Serviço de Cirurgia Plástica, Departamento de Cirurgia Geral, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

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Mariana Renovato-Martins Laboratory of Inflammation and Metabolism, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brasil

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Christina Barja-Fidalgo Laboratory of Celular and Molecular Pharmacology, Departamento de Biologia Celular, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brasil

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microparticles, which are the largest EVs. Cell lines and cultures The breast cancer cell lines MCF-7 (a luminal non-invasive type) and MDA-MB-231 (a basal invasive type) as well as HMEC-1, a human microvasculature endothelial cell line, were obtained

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Tara Williamson Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA

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Thais Biude Mendes Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Natalie Joe Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA

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Janete M Cerutti Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Universidade Federal de São Paulo, São Paulo, Brazil

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Gregory J Riggins Departments of Neurosurgery and Oncology, Johns Hopkins University, Baltimore, Maryland, USA

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% ( Keutgen et al . 2015 ). From its onset, ATC displays highly invasive behavior with a majority of patients exhibiting regional or distant metastases in the course of their disease, primarily to the lungs ( Haddad et al . 2015 ). ATC is largely resistant

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Volker Fendrich
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Jens Waldmann
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Farzad Esni
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Annette Ramaswamy
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Michael Mullendore
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Malte Buchholz
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Anirban Maitra
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Georg Feldmann
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lies around 60% for NETs of the ileum which comprise the majority of the tumors ( Rorstad 2005 ). The presence of metastases, especially to the liver, is associated with a reduced 5-year survival. The increased motility and invasiveness of

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Krystallenia I Alexandraki Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Gregory A Kaltsas Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Simona Grozinsky-Glasberg Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Eleftherios Chatzellis Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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Ashley B Grossman Department of Pathophysiology, Neuroendocrine Tumor Unit, Oxford Centre for Diabetes, National University of Athens, Greece

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studies reported that no patient with a tumour <2 cm treated with a simple appendicectomy developed recurrent or metastatic disease after a median follow-up period >26 years, while a moderate degree of local invasion was not associated with an adverse

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Arja Jukkola
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Risto Bloigu
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Tapani Ebeling
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Pasi Salmela
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Guillermo Blanco
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proportion of the patients develop recurrences and eventually die of the disease. Age at the time of diagnosis, gender, histological type, tumour size and extrathyroidal invasion have been found previously to be associated with a poor clinical outcome

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Pedro Weslley Rosario Santa Casa de Belo Horizonte, Minas Gerais, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Minas Gerais, Brazil

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/well-delimited tumors of FVPTC without vascular/capsular invasion had an excellent prognosis after complete resection, even when treated only with lobectomy ( Liu et al. 2006 , Rivera et al. 2010 , Rosario et al. 2014 , Ganly et al. 2015 ). In the largest

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