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Centre for Colorectal Disease, St. Vincent’s University Hospital, Dublin, Ireland
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Centre for Colorectal Disease, St. Vincent’s University Hospital, Dublin, Ireland
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Department of Medical Oncology, St. Vincent’s University Hospital, Dublin, Ireland
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UCD Clinical Research Centre, St. Vincent's University Hospital, Dublin, Ireland
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surviving fraction was determined by comparing the plating efficiency of treated vs control wells. The total colony area was calculated for each biological replicate by averaging the area of all colonies in replicate wells. Cell invasion assays Cell
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Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
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Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
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Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
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Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Surgery, Haukeland University Hospital, Department of Surgical Sciences, Institute of Medicine, University of Bergen, Klinik für Chirurgie and Zentrum für Minimal Invasive Chirurgie, Klinikum Essen-Mitte, Department of Molecular Biology, Institute of Medicine, University of Bergen, Department of Clinical Genetics, County Council of Östergötland, Department of Surgery, County Council of Östergötland, SE-58183, Linköping, Sweden
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expression in tumor cells influence cell proliferation, differentiation, survival and invasion in a variety of neoplasms in a cell type-specific manner ( Lin et al . 2008 , Dentice et al . 2009 , Pinto et al . 2011 ). The function of THs and TRs in
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cancers, its expression is associated with tumor invasiveness and aggressive behavior ( Heaney et al . 2000 , Boelaert et al . 2003 a ). PTTG is implicated in several normal cellular processes, including DNA damage repair, apoptosis, and angiogenesis
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microparticles, which are the largest EVs. Cell lines and cultures The breast cancer cell lines MCF-7 (a luminal non-invasive type) and MDA-MB-231 (a basal invasive type) as well as HMEC-1, a human microvasculature endothelial cell line, were obtained
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% ( Keutgen et al . 2015 ). From its onset, ATC displays highly invasive behavior with a majority of patients exhibiting regional or distant metastases in the course of their disease, primarily to the lungs ( Haddad et al . 2015 ). ATC is largely resistant
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lies around 60% for NETs of the ileum which comprise the majority of the tumors ( Rorstad 2005 ). The presence of metastases, especially to the liver, is associated with a reduced 5-year survival. The increased motility and invasiveness of
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studies reported that no patient with a tumour <2 cm treated with a simple appendicectomy developed recurrent or metastatic disease after a median follow-up period >26 years, while a moderate degree of local invasion was not associated with an adverse
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proportion of the patients develop recurrences and eventually die of the disease. Age at the time of diagnosis, gender, histological type, tumour size and extrathyroidal invasion have been found previously to be associated with a poor clinical outcome
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/well-delimited tumors of FVPTC without vascular/capsular invasion had an excellent prognosis after complete resection, even when treated only with lobectomy ( Liu et al. 2006 , Rivera et al. 2010 , Rosario et al. 2014 , Ganly et al. 2015 ). In the largest