Filter

Refine by collections

Refine by date

—

Refine by access

  • Print
  • Save

Search Results

You are looking at 81 - 90 of 384 items for :

  • "genetic alterations" x
  • Refine by access: All content x
Clear All
Faith Nutter Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Faith Nutter in
Google Scholar
PubMed Close
,
Ingunn Holen Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Ingunn Holen in
Google Scholar
PubMed Close
,
Hannah K Brown Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Hannah K Brown in
Google Scholar
PubMed Close
,
Simon S Cross Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Simon S Cross in
Google Scholar
PubMed Close
,
C Alyson Evans Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by C Alyson Evans in
Google Scholar
PubMed Close
,
Matthew Walker Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Matthew Walker in
Google Scholar
PubMed Close
,
Robert E Coleman Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Robert E Coleman in
Google Scholar
PubMed Close
,
Jules A Westbrook Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Jules A Westbrook in
Google Scholar
PubMed Close
,
Peter J Selby Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Peter J Selby in
Google Scholar
PubMed Close
,
Janet E Brown Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre
Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Janet E Brown in
Google Scholar
PubMed Close
, and
Penelope D Ottewell Academic Unit of Clinical Oncology, Academic Unit of Pathology, Leeds Institute of Molecular Medicine, Cancer Research UK (CR‐UK), and Yorkshire Cancer Research (YCR) Sheffield Cancer Research Centre

Search for other papers by Penelope D Ottewell in
Google Scholar
PubMed Close

-IV tumours at any point over a 30 day time period, mean tumour area of 4.4±1.1 mm 2 being recorded for MDA-P cells and 3.4±1.7 mm 2 for MDA-IV cells at 35 days ( Fig. 3 c). Genetic alterations associated with bone-homing Intravenous injection of MDA

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0158
Volume/Issue:
Volume 21: Issue 2
Free access
Ali S Alzahrani Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Search for other papers by Ali S Alzahrani in
Google Scholar
PubMed Close
,
Meshael Alswailem Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Search for other papers by Meshael Alswailem in
Google Scholar
PubMed Close
,
Alexandre Buffet Université Paris Cité, Inserm, Paris Centre de Recherche Cardiovasculaire (PARCC), Equipe Labellisée Ligue contre le Cancer, Paris, France
Département de Médecine Génomique des Tumeurs et des Cancers, Fédération de Génétique et de Médecine Génomique, Assistance Publique-Hôpitaux de Paris (AP-HP) Centre, Hôpital Européen Georges Pompidou, Paris, France

Search for other papers by Alexandre Buffet in
Google Scholar
PubMed Close
,
Balgees Alghamdi Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Search for other papers by Balgees Alghamdi in
Google Scholar
PubMed Close
,
Lulu Alobaid Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Search for other papers by Lulu Alobaid in
Google Scholar
PubMed Close
,
Osamah Alsagheir Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Search for other papers by Osamah Alsagheir in
Google Scholar
PubMed Close
,
Hindi Al-Hindi Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Search for other papers by Hindi Al-Hindi in
Google Scholar
PubMed Close
, and
Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

Search for other papers by Karel Pacak in
Google Scholar
PubMed Close

approximately additional 30% of PPGLs carry somatic or postzygotic pathogenic variants ( Fishbein et al. 2017 , Nölting et al. 2021 ). These genetic alterations have been classified into at least three clusters based on their gene expression profiles

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0303
Volume/Issue:
Volume 31: Issue 8
Restricted access
Tanner Freeman Department of Pathology, UPMC, Pittsburgh, Pennsylvania, USA

Search for other papers by Tanner Freeman in
Google Scholar
PubMed Close
,
Charit Taneja Division of Endocrinology and Metabolism, UPMC, Pittsburgh, Pennsylvania, USA

Search for other papers by Charit Taneja in
Google Scholar
PubMed Close
,
N Paul Ohori Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by N Paul Ohori in
Google Scholar
PubMed Close
,
Abigail I Wald Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Abigail I Wald in
Google Scholar
PubMed Close
,
John Skaugen Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by John Skaugen in
Google Scholar
PubMed Close
,
Linwah Yip Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Linwah Yip in
Google Scholar
PubMed Close
,
Seungwon Kim Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Seungwon Kim in
Google Scholar
PubMed Close
,
Robert L Ferris Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
UPMC Hillman Cancer Center, Department of Oncology, Pittsburgh, Pennsylvania, USA

Search for other papers by Robert L Ferris in
Google Scholar
PubMed Close
,
Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Marina N Nikiforova in
Google Scholar
PubMed Close
,
Somak Roy Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Somak Roy in
Google Scholar
PubMed Close
, and
Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Yuri E Nikiforov in
Google Scholar
PubMed Close

molecularly identified thyroidal metastasis of renal cell carcinoma and genetic alterations detected in FNAs by ThyroSeq testing. Case Age (y); gender Nodule size (cm) BCC Cytologic features a Multiple nodules USG History of RCC

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0195
Volume/Issue:
Volume 29: Issue 12
Restricted access
Giovanna Maria Pierantoni
Search for other papers by Giovanna Maria Pierantoni in
Google Scholar
PubMed Close
,
Palma Finelli
Search for other papers by Palma Finelli in
Google Scholar
PubMed Close
,
Emanuele Valtorta
Search for other papers by Emanuele Valtorta in
Google Scholar
PubMed Close
,
Daniela Giardino
Search for other papers by Daniela Giardino in
Google Scholar
PubMed Close
,
Ornella Rodeschini
Search for other papers by Ornella Rodeschini in
Google Scholar
PubMed Close
,
Francesco Esposito
Search for other papers by Francesco Esposito in
Google Scholar
PubMed Close
,
Marco Losa
Search for other papers by Marco Losa in
Google Scholar
PubMed Close
,
Alfredo Fusco
Search for other papers by Alfredo Fusco in
Google Scholar
PubMed Close
, and
Lidia Larizza
Search for other papers by Lidia Larizza in
Google Scholar
PubMed Close

-functioning pituitary adenomas (NFPAs). The genesis of pituitary tumors is still under investigation since the genetic alterations of the pituicytes themselves, hypothalamic dysregulation and locally produced growth factors have not been integrated in a multistep model

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.01049
Volume/Issue:
Volume 12: Issue 4
Free access
Glenn T G Chang
Search for other papers by Glenn T G Chang in
Google Scholar
PubMed Close
,
Mila Jhamai
Search for other papers by Mila Jhamai in
Google Scholar
PubMed Close
,
Wytske M van Weerden
Search for other papers by Wytske M van Weerden in
Google Scholar
PubMed Close
,
Guido Jenster
Search for other papers by Guido Jenster in
Google Scholar
PubMed Close
, and
Albert O Brinkmann
Search for other papers by Albert O Brinkmann in
Google Scholar
PubMed Close

-repressible apoptosis gene. Apoptosis 7 13 –21. Cher ML , Bova GS, Moore DH, Small EJ, Carroll PR, Pin SS, Epstein JI, Isaacs WB & Jensen RH 1996 Genetic alterations in untreated metastases and androgen-independent prostate cancer

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00853
Volume/Issue:
Volume 11: Issue 4
Free access
Angel Chao Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Angel Chao in
Google Scholar
PubMed Close
,
Huei-Jean Huang Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Huei-Jean Huang in
Google Scholar
PubMed Close
,
Chiao-Yun Lin Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Chiao-Yun Lin in
Google Scholar
PubMed Close
,
Chia-Hwa Lee Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Chia-Hwa Lee in
Google Scholar
PubMed Close
,
Chien-Hsing Lin Taiwan Genomic Industry Alliance Inc., Taipei, Taiwan

Search for other papers by Chien-Hsing Lin in
Google Scholar
PubMed Close
,
An-Shine Chao Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Department of Obstetrics and Gynecology, New Taipei Municipal Tu Cheng Hospital, New Taipei City, Taiwan

Search for other papers by An-Shine Chao in
Google Scholar
PubMed Close
,
Chyong-Huey Lai Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Chyong-Huey Lai in
Google Scholar
PubMed Close
,
Ting-Chang Chang Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Ting-Chang Chang in
Google Scholar
PubMed Close
,
Kai-Yun Wu Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Kai-Yun Wu in
Google Scholar
PubMed Close
, and
Ren-Chin Wu Gynecologic Cancer Research Center, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Department of Anatomic Pathology, Linkou Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan

Search for other papers by Ren-Chin Wu in
Google Scholar
PubMed Close

patients (#SCT-01 and #SCT-03) had negative results on the TSO500 assay and underwent confirmatory testing with WES. The genetic alterations identified in the seven SCTs NOS samples are summarized in Table 2 . In brief, mutations in two hypoxia

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0179
Volume/Issue:
Volume 30: Issue 11
Restricted access
Arivarasan Karunamurthy Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Search for other papers by Arivarasan Karunamurthy in
Google Scholar
PubMed Close
,
Federica Panebianco Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Search for other papers by Federica Panebianco in
Google Scholar
PubMed Close
,
Susan J Hsiao Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Search for other papers by Susan J Hsiao in
Google Scholar
PubMed Close
,
Jennie Vorhauer Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Search for other papers by Jennie Vorhauer in
Google Scholar
PubMed Close
,
Marina N Nikiforova Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Search for other papers by Marina N Nikiforova in
Google Scholar
PubMed Close
,
Simion Chiosea Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Search for other papers by Simion Chiosea in
Google Scholar
PubMed Close
, and
Yuri E Nikiforov Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Search for other papers by Yuri E Nikiforov in
Google Scholar
PubMed Close

encapsulated, is a typical phenotype of EIF1AX -mutated PTC. Since the follicular variant of PTC is known to share genetic alterations with other follicular-patterned thyroid tumors, that is, FTC and FA ( Nikiforov & Nikiforova 2011 ), it was important to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0043
Volume/Issue:
Volume 23: Issue 4
Free access
David Viola Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by David Viola in
Google Scholar
PubMed Close
,
Laura Valerio Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Laura Valerio in
Google Scholar
PubMed Close
,
Eleonora Molinaro Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Eleonora Molinaro in
Google Scholar
PubMed Close
,
Laura Agate Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Laura Agate in
Google Scholar
PubMed Close
,
Valeria Bottici Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Valeria Bottici in
Google Scholar
PubMed Close
,
Agnese Biagini Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Agnese Biagini in
Google Scholar
PubMed Close
,
Loredana Lorusso Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Loredana Lorusso in
Google Scholar
PubMed Close
,
Virginia Cappagli Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Virginia Cappagli in
Google Scholar
PubMed Close
,
Letizia Pieruzzi Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Letizia Pieruzzi in
Google Scholar
PubMed Close
,
Carlotta Giani Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Carlotta Giani in
Google Scholar
PubMed Close
,
Elena Sabini Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Elena Sabini in
Google Scholar
PubMed Close
,
Paolo Passannati Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Paolo Passannati in
Google Scholar
PubMed Close
,
Luciana Puleo Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Luciana Puleo in
Google Scholar
PubMed Close
,
Antonio Matrone Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Antonio Matrone in
Google Scholar
PubMed Close
,
Benedetta Pontillo-Contillo Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

Search for other papers by Benedetta Pontillo-Contillo in
Google Scholar
PubMed Close
,
Valentina Battaglia Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

Search for other papers by Valentina Battaglia in
Google Scholar
PubMed Close
,
Salvatore Mazzeo Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

Search for other papers by Salvatore Mazzeo in
Google Scholar
PubMed Close
,
Paolo Vitti Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Paolo Vitti in
Google Scholar
PubMed Close
, and
Rossella Elisei Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, Pisa, Italy

Search for other papers by Rossella Elisei in
Google Scholar
PubMed Close

-RAS mutations are found in a relatively small percentage of PTCs, they represent the most frequent genetic alterations in FTCs, and they are also significantly present in PDTCs and ATCs ( Xing 2013 ). Other common genetic alterations in FTCs are PTEN deletion

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0555
Volume/Issue:
Volume 23: Issue 4
Free access
Sunmi Park Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

Search for other papers by Sunmi Park in
Google Scholar
PubMed Close
,
Mark C Willingham Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

Search for other papers by Mark C Willingham in
Google Scholar
PubMed Close
,
Jun Qi Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

Search for other papers by Jun Qi in
Google Scholar
PubMed Close
, and
Sheue-Yann Cheng Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

Search for other papers by Sheue-Yann Cheng in
Google Scholar
PubMed Close

reported that genetic alterations in the PI3K-AKT pathway play a critical role in thyroid tumorigenesis and progression ( Hou et al . 2007 , Wang et al . 2007 , Xing 2010 ). Furthermore, association of PTEN methylation with the activating genetic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0071
Volume/Issue:
Volume 25: Issue 10
Free access
Thomas J Giordano Divisions of Anatomic Pathology and Molecular & Genomic Pathology, Departments of Pathology and Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA

Search for other papers by Thomas J Giordano in
Google Scholar
PubMed Close

of tumor classification schemes. Together with the identification of novel genetic alterations, these results have profound implications for the treatment of cancer patients. Tumors of endocrine organs are similarly genomic diseases. Compared to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0116
Volume/Issue:
Volume 25: Issue 8
Free access