Search Results

You are looking at 81 - 90 of 277 items for :

  • Refine by access: All content x
Clear All
Zhe Wang Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Zhe Wang in
Google Scholar
PubMed
Close
,
Ke Ma Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Ke Ma in
Google Scholar
PubMed
Close
,
Steffie Pitts Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Steffie Pitts in
Google Scholar
PubMed
Close
,
Yulan Cheng Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Yulan Cheng in
Google Scholar
PubMed
Close
,
Xi Liu Department of Pathology, The First Affiliated Hospital of Xi’ an Jiaotong University, Xi’ an, Shaanxi, China

Search for other papers by Xi Liu in
Google Scholar
PubMed
Close
,
Xiquan Ke Department of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China

Search for other papers by Xiquan Ke in
Google Scholar
PubMed
Close
,
Samuel Kovaka Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

Search for other papers by Samuel Kovaka in
Google Scholar
PubMed
Close
,
Hassan Ashktorab Cancer Center, Howard University School of Medicine, Washington, District of Columbia, USA

Search for other papers by Hassan Ashktorab in
Google Scholar
PubMed
Close
,
Duane T Smoot Department of Medicine, Meharry Medical College, Nashville, Tennessee, USA

Search for other papers by Duane T Smoot in
Google Scholar
PubMed
Close
,
Michael Schatz Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

Search for other papers by Michael Schatz in
Google Scholar
PubMed
Close
,
Zhirong Wang Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

Search for other papers by Zhirong Wang in
Google Scholar
PubMed
Close
, and
Stephen J Meltzer Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Stephen J Meltzer in
Google Scholar
PubMed
Close

−ΔΔCt ) method and normalized against the threshold cycle (Ct) of GAPDH or β-actin. For detecting expression levels of miRNA, cDNA samples were amplified using TaqMan MicroRNA Assays (Applied Biosystems), and RNU6B was used as a reference gene

Free access
Enzo Lalli Université Côte d’Azur, Valbonne, France
CNRS UMR7275, Valbonne, France
NEOGENEX CNRS International Associated Laboratory, Valbonne, France
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France

Search for other papers by Enzo Lalli in
Google Scholar
PubMed
Close
and
Michaela Luconi Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

Search for other papers by Michaela Luconi in
Google Scholar
PubMed
Close

– mitotane (EDP-M) treatment ( Roca et al. 2017 ). MicroRNAs (miRNAs) are a class of evolutionarily conserved, small non-coding RNA molecules which regulate gene expression at the post-transcriptional level. They are implicated in virtually every

Free access
Samantha Peiling Yang Endocrinology Division, Department of Medicine, National University Hospital of Singapore, Singapore, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Search for other papers by Samantha Peiling Yang in
Google Scholar
PubMed
Close
and
Joanne Ngeow Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre, Singapore, Singapore
Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore

Search for other papers by Joanne Ngeow in
Google Scholar
PubMed
Close

). Patients with the clinical phenotype of Werner syndrome should be screened for thyroid cancer, and genetic testing for WRN gene mutation can be performed. DICER1 syndrome MicroRNAs (miRNAs) are single-stranded, short (22-nucleotides long) and non

Free access
Chiara Borga Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

Search for other papers by Chiara Borga in
Google Scholar
PubMed
Close
,
Carlo Alberto Dal Pozzo Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

Search for other papers by Carlo Alberto Dal Pozzo in
Google Scholar
PubMed
Close
,
Elisabetta Trevellin Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

Search for other papers by Elisabetta Trevellin in
Google Scholar
PubMed
Close
,
Francesca Bergamo Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

Search for other papers by Francesca Bergamo in
Google Scholar
PubMed
Close
,
Sabina Murgioni Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

Search for other papers by Sabina Murgioni in
Google Scholar
PubMed
Close
,
Anna Caterina Milanetto Department of Oncology, Surgery and Gastroenterology (DISCOG), Surgery 1, Pancreatic and Endocrine Digestive Surgical Unit, University of Padua, Padua, Italy

Search for other papers by Anna Caterina Milanetto in
Google Scholar
PubMed
Close
,
Claudio Pasquali Department of Oncology, Surgery and Gastroenterology (DISCOG), Surgery 1, Pancreatic and Endocrine Digestive Surgical Unit, University of Padua, Padua, Italy

Search for other papers by Claudio Pasquali in
Google Scholar
PubMed
Close
,
Umberto Cillo Department of Oncology, Surgery and Gastroenterology (DISCOG), Hepatobiliary Surgery and Liver Transplant Unit, University of Padua, Padua, Italy

Search for other papers by Umberto Cillo in
Google Scholar
PubMed
Close
,
Giada Munari Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

Search for other papers by Giada Munari in
Google Scholar
PubMed
Close
,
Chiara Martini Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

Search for other papers by Chiara Martini in
Google Scholar
PubMed
Close
,
Eugenio De Carlo Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

Search for other papers by Eugenio De Carlo in
Google Scholar
PubMed
Close
,
Vittorina Zagonel Medical Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

Search for other papers by Vittorina Zagonel in
Google Scholar
PubMed
Close
,
Vincenza Guzzardo Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

Search for other papers by Vincenza Guzzardo in
Google Scholar
PubMed
Close
,
Gianmaria Pennelli Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

Search for other papers by Gianmaria Pennelli in
Google Scholar
PubMed
Close
,
Angelo Paolo Dei Tos Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy

Search for other papers by Angelo Paolo Dei Tos in
Google Scholar
PubMed
Close
,
Roberto Vettor Department of Medicine (DIMED), Endocrine-Metabolic Laboratory, University of Padua, Padua, Italy

Search for other papers by Roberto Vettor in
Google Scholar
PubMed
Close
, and
Matteo Fassan Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy
Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

Search for other papers by Matteo Fassan in
Google Scholar
PubMed
Close

between the key components of the molecular pathways investigated in this study. Black arrow: activation, red line: inhibition. Abbreviations: AKT, protein-kinase B; MAPK, mitogen-activated protein kinase; miR-21, microRNA-21; mTOR, mammalian target of

Restricted access
Patricia V Elizalde Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina

Search for other papers by Patricia V Elizalde in
Google Scholar
PubMed
Close
,
Rosalía I Cordo Russo Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina

Search for other papers by Rosalía I Cordo Russo in
Google Scholar
PubMed
Close
,
Maria F Chervo Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina

Search for other papers by Maria F Chervo in
Google Scholar
PubMed
Close
, and
Roxana Schillaci Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina

Search for other papers by Roxana Schillaci in
Google Scholar
PubMed
Close

ErbB-2 function by recruiting ErbB-2 as its coactivator at the GAS sites in the promoter of microRNA-21 (miR-21), a miRNA whose expression is regulated by MErbB-2, and whose metastasis-promoting effects in BC are well acknowledged ( Loffler et al

Free access
Simone de Brot Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Simone de Brot in
Google Scholar
PubMed
Close
,
Atara Ntekim Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Atara Ntekim in
Google Scholar
PubMed
Close
,
Ryan Cardenas Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Ryan Cardenas in
Google Scholar
PubMed
Close
,
Victoria James Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Victoria James in
Google Scholar
PubMed
Close
,
Cinzia Allegrucci Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Cinzia Allegrucci in
Google Scholar
PubMed
Close
,
David M Heery Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by David M Heery in
Google Scholar
PubMed
Close
,
David O Bates Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by David O Bates in
Google Scholar
PubMed
Close
,
Niels Ødum Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Niels Ødum in
Google Scholar
PubMed
Close
,
Jenny L Persson Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Jenny L Persson in
Google Scholar
PubMed
Close
, and
Nigel P Mongan Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK
Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK

Search for other papers by Nigel P Mongan in
Google Scholar
PubMed
Close

) ( Chakravarty et al . 2014 ) to the VEGF promoter. (C) Positions of microRNA target sites and internal ribosome entry sites (IRES) in relation to the coding sequence of the VEGF. Interestingly, recent studies have identified pro- and anti-angiogenic VEGF

Free access
Darrell Green Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK

Search for other papers by Darrell Green in
Google Scholar
PubMed
Close
,
Irina Mohorianu School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK

Search for other papers by Irina Mohorianu in
Google Scholar
PubMed
Close
,
Iain McNamara Department of Orthopaedics and Trauma, Norfolk and Norwich University Hospital, Norwich Research Park, Norwich, UK

Search for other papers by Iain McNamara in
Google Scholar
PubMed
Close
,
Tamas Dalmay School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK

Search for other papers by Tamas Dalmay in
Google Scholar
PubMed
Close
, and
William D Fraser Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK
Department of Diabetes and Endocrinology, Norfolk and Norwich University Hospital, Norwich Research Park, Norwich, UK

Search for other papers by William D Fraser in
Google Scholar
PubMed
Close

evaluate the expression of small RNAs such as microRNAs (miRNAs) in PDB and PDB-OS. MiRNAs are key regulators of gene expression through gene silencing. MiRNAs can also be used as biomarkers to classify poorly differentiated cancers and cancer tissue

Free access
Christodoulos P Pipinikas Medical Genomics Laboratory, University College London Cancer Institute, London, UK

Search for other papers by Christodoulos P Pipinikas in
Google Scholar
PubMed
Close
,
Alison M Berner Medical Genomics Laboratory, University College London Cancer Institute, London, UK

Search for other papers by Alison M Berner in
Google Scholar
PubMed
Close
,
Teresa Sposito Medical Genomics Laboratory, University College London Cancer Institute, London, UK

Search for other papers by Teresa Sposito in
Google Scholar
PubMed
Close
, and
Christina Thirlwell Medical Genomics Laboratory, University College London Cancer Institute, London, UK
Neuroendocrine Tumour Unit and Department of Oncology, Royal Free Hospital, London, UK

Search for other papers by Christina Thirlwell in
Google Scholar
PubMed
Close

menin results in H3K4me3 loss and gene downregulation and gives rise to MEN1-like sporadic pancreatic tumours ( Agarwal & Jothi 2012 ). Post-transcriptional control (microRNAs and lncRNAs) Non-coding RNAs (ncRNAs) are post-transcriptional gene

Free access
Brahim Aissani Department of Epidemiology, Department of Biostatistics, Department of Human Genetics, Netherlands Cancer Institute, R217J

Search for other papers by Brahim Aissani in
Google Scholar
PubMed
Close
,
Kui Zhang Department of Epidemiology, Department of Biostatistics, Department of Human Genetics, Netherlands Cancer Institute, R217J

Search for other papers by Kui Zhang in
Google Scholar
PubMed
Close
,
Arjen R Mensenkamp Department of Epidemiology, Department of Biostatistics, Department of Human Genetics, Netherlands Cancer Institute, R217J

Search for other papers by Arjen R Mensenkamp in
Google Scholar
PubMed
Close
,
Fred H Menko Department of Epidemiology, Department of Biostatistics, Department of Human Genetics, Netherlands Cancer Institute, R217J

Search for other papers by Fred H Menko in
Google Scholar
PubMed
Close
, and
Howard W Wiener Department of Epidemiology, Department of Biostatistics, Department of Human Genetics, Netherlands Cancer Institute, R217J

Search for other papers by Howard W Wiener in
Google Scholar
PubMed
Close

molecules reported to be differentially expressed in fibroids vs myometrium are microRNA (miRNA) species. LncRNAs form a specific group of non-coding RNAs ( Woo & Kingston 2007 ) transcribed from ultraconserved intergenic regions and implicated in complex

Open access
Qu Deng Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA

Search for other papers by Qu Deng in
Google Scholar
PubMed
Close
and
Dean G Tang Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA

Search for other papers by Dean G Tang in
Google Scholar
PubMed
Close

setting might be helpful in preventing CRPC. Preclinical studies in PCSCs targeting have provided promising results. For instance, we have demonstrated that microRNA-34a (miR-34a) potently inhibits the PCa progression and metastasis via directly targeting

Free access