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Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
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−ΔΔCt ) method and normalized against the threshold cycle (Ct) of GAPDH or β-actin. For detecting expression levels of miRNA, cDNA samples were amplified using TaqMan MicroRNA Assays (Applied Biosystems), and RNU6B was used as a reference gene
CNRS UMR7275, Valbonne, France
NEOGENEX CNRS International Associated Laboratory, Valbonne, France
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France
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– mitotane (EDP-M) treatment ( Roca et al. 2017 ). MicroRNAs (miRNAs) are a class of evolutionarily conserved, small non-coding RNA molecules which regulate gene expression at the post-transcriptional level. They are implicated in virtually every
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore
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). Patients with the clinical phenotype of Werner syndrome should be screened for thyroid cancer, and genetic testing for WRN gene mutation can be performed. DICER1 syndrome MicroRNAs (miRNAs) are single-stranded, short (22-nucleotides long) and non
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Veneto Institute of Oncology IOV - IRCCS, Padua, Italy
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between the key components of the molecular pathways investigated in this study. Black arrow: activation, red line: inhibition. Abbreviations: AKT, protein-kinase B; MAPK, mitogen-activated protein kinase; miR-21, microRNA-21; mTOR, mammalian target of
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ErbB-2 function by recruiting ErbB-2 as its coactivator at the GAS sites in the promoter of microRNA-21 (miR-21), a miRNA whose expression is regulated by MErbB-2, and whose metastasis-promoting effects in BC are well acknowledged ( Loffler et al
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Faculty of Medicine and Health Sciences, Department of Pharmacology, Cancer Biology, Department of International Health, Clinical Research Center, Department of Pharmacology, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD, UK
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) ( Chakravarty et al . 2014 ) to the VEGF promoter. (C) Positions of microRNA target sites and internal ribosome entry sites (IRES) in relation to the coding sequence of the VEGF. Interestingly, recent studies have identified pro- and anti-angiogenic VEGF
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Department of Diabetes and Endocrinology, Norfolk and Norwich University Hospital, Norwich Research Park, Norwich, UK
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evaluate the expression of small RNAs such as microRNAs (miRNAs) in PDB and PDB-OS. MiRNAs are key regulators of gene expression through gene silencing. MiRNAs can also be used as biomarkers to classify poorly differentiated cancers and cancer tissue
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Neuroendocrine Tumour Unit and Department of Oncology, Royal Free Hospital, London, UK
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menin results in H3K4me3 loss and gene downregulation and gives rise to MEN1-like sporadic pancreatic tumours ( Agarwal & Jothi 2012 ). Post-transcriptional control (microRNAs and lncRNAs) Non-coding RNAs (ncRNAs) are post-transcriptional gene
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molecules reported to be differentially expressed in fibroids vs myometrium are microRNA (miRNA) species. LncRNAs form a specific group of non-coding RNAs ( Woo & Kingston 2007 ) transcribed from ultraconserved intergenic regions and implicated in complex
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
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Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
Department of Epigenetics and Molecular Carcinogenesis, Program in Molecular Carcinogenesis, Cancer Stem Cell Institute, University of Texas MD Anderson Cancer Center, Science Park, Park Road 1C, Smithville, Texas 78957, USA
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setting might be helpful in preventing CRPC. Preclinical studies in PCSCs targeting have provided promising results. For instance, we have demonstrated that microRNA-34a (miR-34a) potently inhibits the PCa progression and metastasis via directly targeting