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Nora Sahnane Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Daniela Furlan Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Matilde Monti Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Chiara Romualdi Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Alessandro Vanoli Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Emanuela Vicari Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Enrico Solcia Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Carlo Capella Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Fausto Sessa Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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Stefano La Rosa Section of Anatomic Pathology, CRIBI Biotechnology Center, Department of Molecular Medicine, Department of Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy

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patients had a history of primary pulmonary neuroendocrine neoplasms. Clinical information including sex, age, type of surgery, clinical history, the presence of distant metastases, and follow-up findings was collected by consulting clinical charts. This

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Mintallah Haider Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA

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Satya Das Department of GI Oncology, Vanderbilt University, Nashville, Tennessee, USA

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Taymeyah Al-Toubah Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA

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Eleonora Pelle Department of Oncology, University of Bari, Bari, Puglia, Italy

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Ghassan El-Haddad Moffitt Cancer Center, Department of Diagnostic Imaging and Interventional Radiology, Tampa, Florida, USA

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Jonathan Strosberg Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA

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)Yttrium and (177)Lutetium in 1048 patients with neuroendocrine neoplasm . Oncotarget 9 16932 – 16950 . ( https://doi.org/10.18632/oncotarget.24524 ) Bodei L Kidd M Paganelli G Grana CM Drozdov I Cremonesi M Lepensky C Kwekkeboom DJ

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Rushabh Gujarathi Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA

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Sara Abou Azar Section of Endocrine Surgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA

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Joseph Tobias Section of Endocrine Surgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA

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Blase N Polite Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA

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Namrata Setia Department of Pathology, University of Chicago, Chicago, Illinois, USA

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Nicholas Feinberg Department of Radiology, University of Chicago, Chicago, Illinois, USA

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Daniel E Appelbaum Department of Radiology, University of Chicago, Chicago, Illinois, USA

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Xavier M Keutgen Section of Endocrine Surgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA

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Chih-Yi Liao Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA

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Introduction Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs), the most common type of neuroendocrine neoplasms, are often metastatic at the time of presentation ( Yao et al. 2008 , Dasari et al. 2017 ). Peptide

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Louis de Mestier Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

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Anne Couvelard Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

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Anela Blazevic Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Olivia Hentic Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France

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Wouter W de Herder Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Vinciane Rebours Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

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Valérie Paradis Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

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Philippe Ruszniewski Department of Gastroenterology-Pancreatology, ENETS Centre of Excellence, Beaujon University Hospital (APHP), and Université de Paris, Clichy, France
Centre of Research on Inflammation, INSERM U1149, Paris, France

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Leo J Hofland Division Endocrinology, Department of Internal Medicine, ENETS Centre of Excellence, Erasmus Medical Center, Rotterdam, The Netherlands

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Jérôme Cros Centre of Research on Inflammation, INSERM U1149, Paris, France
Department of Pathology, ENETS Centre of Excellence, Bichat/Beaujon University Hospitals (APHP), and Université de Paris, Clichy/Paris, France

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to temozolomide-based therapy in neuroendocrine neoplasms: an observational retrospective multicenter study . Endocrine 60 490 – 498 . ( https://doi.org/10.1007/s12020-017-1474-3 ) Candiloro ILM Dobrovic A 2009 Detection of MGMT

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Anela Blazevic Department of Internal Medicine, section Endocrinology, Erasmus MC, Rotterdam,

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Martijn P A Starmans Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands

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Tessa Brabander Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands

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Roy S Dwarkasing Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands

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Renza A H van Gils Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands

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Johannes Hofland Department of Internal Medicine, section Endocrinology, Erasmus MC, Rotterdam,

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Gaston J H Franssen Department of Surgery, Erasmus MC, Rotterdam, the Netherlands

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Richard A Feelders Department of Internal Medicine, section Endocrinology, Erasmus MC, Rotterdam,

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Wiro J Niessen Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands
Faculty of Applied Sciences, Department of Radiology and Nuclear Medicine, Delft University of Technology, Delft, the Netherlands

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Stefan Klein Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands

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Wouter W de Herder Department of Internal Medicine, section Endocrinology, Erasmus MC, Rotterdam,

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predicts the overall survival of patients with gastroenteropancreatic neuroendocrine neoplasms . British Journal of Cancer 117 1544 – 1550 . ( https://doi.org/10.1038/bjc.2017.315 ) Fortin JP Parker D Tunç B Watanabe T Elliott MA Ruparel

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Luohai Chen Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Institute for Liver and Digestive Disease, Royal Free Hospital, University College London, London, UK

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Gopinath Gnanasegaran Department of Nuclear Medicine, Royal Free London NHS Foundation, London, UK

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Dalvinder Mandair Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Christos Toumpanakis Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Martyn Caplin Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation, London, UK

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Shaunak Navalkissoor Department of Nuclear Medicine, Royal Free London NHS Foundation, London, UK

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neuroendocrine neoplasms: a large series from a single institution . Neuroendocrinology 100 240 – 249 . ( https://doi.org/10.1159/000369818 ) Modlin IM Gustafsson BI Moss SF Pavel M Tsolakis AV Kidd M 2010 Chromogranin A – biological function and

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Chiara Alessandra Cella Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy
Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy

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Riccardo Cazzoli Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy
Metal Targeted Therapy & Immunology lab, Childrens’ cancer institute, Sydney, NSW, Australia

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Nicola Fazio Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Giuseppina De Petro Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy

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Germano Gaudenzi Laboratory of Geriatric and Oncologic Neuroendocrinology Research, IRCCS, Istituto Auxologico Italiano, Milan, Italy

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Silvia Carra Laboratory of Endocrine and Metabolic Research, IRCCS, Istituto Auxologico Italiano, Milan, Italy

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Mauro Romanenghi Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Francesca Spada Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Ilaria Grossi Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy

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Isabella Pallavicini Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy

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Saverio Minucci Department of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

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Giovanni Vitale Laboratory of Geriatric and Oncologic Neuroendocrinology Research, IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Introduction Neuroendocrine neoplasms (NENs) constitute a highly heterogeneous spectrum of malignancies. In the majority of cases, they appear as well-differentiated or a low/intermediate grade of malignancy and are termed neuroendocrine

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Saya Ahmad Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, the Netherlands

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Myrthe R Naber Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, the Netherlands

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Rachel H Giles Dutch VHL Organization, Utrecht, the Netherlands

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Gerlof D Valk Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, the Netherlands

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Rachel S van Leeuwaarde Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, the Netherlands

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patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine neoplasms (PNETs) . Surgery 142 814.e2 –81 8 .e 2 ( https://doi.org/10.1016/j.surg.2007.09.012 ) Bucau M Laurent-Bellue A Poté N Hentic O Cros J Mikail

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Julie Refardt ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
ENETS Center of Excellence, Department of Endocrinology, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Wouter T Zandee ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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Tessa Brabander ENETS Center of Excellence, Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Richard A Feelders ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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Gaston J H Franssen Department of Surgery, Section of Surgical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands

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Leo J Hofland ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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Emanuel Christ ENETS Center of Excellence, Department of Endocrinology, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Wouter W de Herder ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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Johannes Hofland ENETS Center of Excellence, Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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Introduction Neuroendocrine neoplasms (NENs) consist of a diverse group of tumors arising from neuroendocrine cells and are mainly localized in the intestine, pancreas and lung ( Hofland et al. 2020 ). Classification of NENs is based on

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Wenzel M Hackeng Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

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Lodewijk A A Brosens Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

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Koen M A Dreijerink Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Endocrinology, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, The Netherlands

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G Driessen A Peeters D Lawrence B Print C Peeters M Van Camp G 2020 PDX1 DNA methylation distinguishes two subtypes of pancreatic neuroendocrine neoplasms with a different prognosis . Cancers (Basel) 12 1461 . ( https://doi.org/10

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