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Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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, the results of second-line (folinic acid, 5-fluorouracil and irinotecan (FOLFIRI)) regimen in G3-NEC have been reported for 19 patients with an RR of 31% and a median progression-free survival (PFS) of 4 months ( Hentic et al . 2012 ). A few years ago
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behavior, according to Fletcher et al. (2002) . A summary of tumor characteristics is given in Tables 1 and 2 . Three tumors had a low mitotic rate (<2), seven displayed a mitotic rate between 2 and 5, and in five tumors the number of mitoses
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patients with either hypertension or angina pectoris and considered a ‘block buster’ medicine. Prof. Sir James Black had the original idea to develop β-blockers, for which he was awarded the Nobel Prize. Although Jim moved from ICI, he became a good friend
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cells express the dominant-negative N-terminal truncated form of the p53 related, p63 gene (i.e. ΔNp63α isotype) within their nucleus and high levels of ‘basal-specific’ cytokeratins (i.e. keratin 5 and 14), glutathione-S-transferase-Pi isoform (GST-P i
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Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany
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Preclinical MRI Center, Charité - Universitätsmedizin Berlin, Berlin, Germany
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Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Translational Oncology of Solid Tumours, Berlin, Germany
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Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
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Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland
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ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System at the University Hospital of Munich, Munich, Germany
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Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland
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-proliferative therapy only for a low proliferation index Ki-67 ≤10%) ( Rinke et al. 2009 , Caplin et al. 2014 ), molecularly targeted therapy (everolimus ( Yao et al. 2011 , 2016 ), sunitinib ( Raymond et al. 2011 )), chemotherapy with streptozotocin/5
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
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chemotherapy or radiotherapy with a poor overall survival of 50% at 5 years ( Adler et al . 2008 ). The identification of reliable diagnostic and prognostic markers and the development of effective molecular therapeutic targets for the treatment of malignant
Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2
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for at least 45 min, 5 days/week for 1 year. At least three sessions/week were facility-based with on-site exercise trainers, and the remaining sessions were home-based. Participants wore heart rate monitors (Polar A3) to maintain workout intensity at
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
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DLL3 Delta-like 3 ( Drosophila ) C DLL4 Delta-like 4 ( Drosophila ) A HES1 Hes family bHLH transcription factor 1 A HES2 Hes family bHLH transcription factor 2 A HES5 Hes family bHLH transcription factor 5 A HEYL Hes-related family bHLH
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
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The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
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The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
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Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
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The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
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day (E) 11.5–E14.5) is most susceptible to bisphenol A (BPA)-induced phenotypes. Observations in DES-exposed daughters suggest that first-trimester exposures to endocrine disrupting compounds (EDCs) are most critical for cancer risk in line with the 7
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-year-old man, in whom thyroidectomy revealed a 3.5 cm tumor with mixed PTCs and ATCs in the left thyroid lobe with extrathyroidal invasion and metastases in 11 out of 18 lymph nodes. Postsurgery imaging showed extensive metastases in the lungs. He died