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J Hadoux Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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D Malka Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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D Planchard Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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J Y Scoazec Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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C Caramella Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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J Guigay Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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V Boige Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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S Leboulleux Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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P Burtin Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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A Berdelou Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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Y Loriot Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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P Duvillard Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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C N Chougnet Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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D Déandréis Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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M Schlumberger Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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I Borget Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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M Ducreux Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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E Baudin Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France

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, the results of second-line (folinic acid, 5-fluorouracil and irinotecan (FOLFIRI)) regimen in G3-NEC have been reported for 19 patients with an RR of 31% and a median progression-free survival (PFS) of 4 months ( Hentic et al . 2012 ). A few years ago

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Sara Ekeblad
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Bengt Nilsson
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Margareta Halin Lejonklou
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Térèse Johansson
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Peter Stålberg
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Ola Nilsson
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Håkan Ahlman
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Britt Skogseid
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behavior, according to Fletcher et al. (2002) . A summary of tumor characteristics is given in Tables 1 and 2 . Three tumors had a low mitotic rate (<2), seven displayed a mitotic rate between 2 and 5, and in five tumors the number of mitoses

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Anne White Endocrinology and Diabetes, Faculties of Medical and Life Sciences, University of Manchester, Manchester, UK

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patients with either hypertension or angina pectoris and considered a ‘block buster’ medicine. Prof. Sir James Black had the original idea to develop β-blockers, for which he was awarded the Nobel Prize. Although Jim moved from ICI, he became a good friend

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P Singh Chemical Therapeutics Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans St. – CRB 162B, Baltimore, Maryland 21231, USA

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A Uzgare Chemical Therapeutics Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans St. – CRB 162B, Baltimore, Maryland 21231, USA

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I Litvinov Chemical Therapeutics Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans St. – CRB 162B, Baltimore, Maryland 21231, USA

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S R Denmeade Chemical Therapeutics Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans St. – CRB 162B, Baltimore, Maryland 21231, USA

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J T Isaacs Chemical Therapeutics Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans St. – CRB 162B, Baltimore, Maryland 21231, USA

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cells express the dominant-negative N-terminal truncated form of the p53 related, p63 gene (i.e. ΔNp63α isotype) within their nucleus and high levels of ‘basal-specific’ cytokeratins (i.e. keratin 5 and 14), glutathione-S-transferase-Pi isoform (GST-P i

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Ajay-Mohan Mohan Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Sonal Prasad Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Fabian Schmitz-Peiffer Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Catharina Lange Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

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Mathias Lukas Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

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Eva J Koziolek Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany

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Jakob Albrecht Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany

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Daniel Messroghli Department of Internal Medicine - Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
Preclinical MRI Center, Charité - Universitätsmedizin Berlin, Berlin, Germany

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Ulrike Stein German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany
Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Translational Oncology of Solid Tumours, Berlin, Germany

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Matthias Ilmer German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany
Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
German Cancer Research Center (DKFZ), Heidelberg, Germany

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Katharina Wang Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Laura Schober Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Astrid Reul Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Julian Maurer Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Juliane Friemel Department of Pathology and Molecular Pathology, University Zurich and University Hospital Zürich, Zurich, Switzerland

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Achim Weber Department of Pathology and Molecular Pathology, University Zurich and University Hospital Zürich, Zurich, Switzerland

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Richard A Zuellig Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Constanze Hantel Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Ralph Fritsch Department of Medical Oncology and Hematology, University Zurich and University Hospital Zürich, Zurich, Switzerland

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Martin Reincke Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany

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Karel Pacak Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health (NIH), Bethesda, Maryland, USA

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Ashley B Grossman Green Templeton College, University of Oxford, London, United Kingdom
Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom
ENETS Centre of Excellence, Royal Free Hospital, London, United Kingdom

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Christoph J Auernhammer Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System at the University Hospital of Munich, Munich, Germany

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Felix Beuschlein Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Winfried Brenner Department of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany

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Nicola Beindorff Berlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Berlin, Germany

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Svenja Nölting Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, University of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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-proliferative therapy only for a low proliferation index Ki-67 ≤10%) ( Rinke et al. 2009 , Caplin et al. 2014 ), molecularly targeted therapy (everolimus ( Yao et al. 2011 , 2016 ), sunitinib ( Raymond et al. 2011 )), chemotherapy with streptozotocin/5

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Goswin Y Meyer-Rochow Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Nicole E Jackson Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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John V Conaglen Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Denis E Whittle Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Muthusamy Kunnimalaiyaan Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Herbert Chen Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Gunnar Westin Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Johanna Sandgren Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Peter Stålberg Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Elham Khanafshar Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Daniel Shibru Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Quan-Yang Duh Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Orlo H Clark Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Electron Kebebew Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Anthony J Gill Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Rory Clifton-Bligh Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Bruce G Robinson Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Diana E Benn Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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Stan B Sidhu Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of
Cancer Genetics, Endocrine and Oncology Surgery, Endocrinology, Anatomical Pathology, Faculty of Medicine, Surgery, Endocrinology, Endocrine Surgery Research Laboratories, Department of Surgical Sciences, Departments of Surgery and Pathology, Endocrine Oncology Section, Hormones and Cancer Group, Kolling Institute of Medical Research, Departments of

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chemotherapy or radiotherapy with a poor overall survival of 50% at 5 years ( Adler et al . 2008 ). The identification of reliable diagnostic and prognostic markers and the development of effective molecular therapeutic targets for the treatment of malignant

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Christine M Friedenreich Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2
Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Heather K Neilson Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Christy G Woolcott Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Anne McTiernan Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Qinggang Wang Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Rachel Ballard-Barbash Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Charlotte A Jones Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Frank Z Stanczyk Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Rollin F Brant Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Yutaka Yasui Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Melinda L Irwin Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Kristin L Campbell Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Margaret L McNeely Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Kristina H Karvinen Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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Kerry S Courneya Department of Population Health Research, Departments of Oncology and Community Health Sciences, Perinatal Epidemiology Research Unit, Prevention Center, Applied Research Program, Department of Medicine, Department of Obstetrics and Gynecology, Department of Statistics, Department of Public Health Sciences, Department of Epidemiology and Public Health, Department of Physical Therapy, Departments of Physical Therapy and Oncology, Department of Exercise and Sports Science, Faculty of Physical Education and Recreation, Alberta Health Services - Cancer Care, Calgary, Alberta, Canada T2N 4N2

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for at least 45 min, 5 days/week for 1 year. At least three sessions/week were facility-based with on-site exercise trainers, and the remaining sessions were home-based. Participants wore heart rate monitors (Polar A3) to maintain workout intensity at

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Freya Mertens Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Lies Gremeaux Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Jianghai Chen Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Qiuli Fu Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium
Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Christophe Willems Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Heleen Roose Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Olivier Govaere Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Tania Roskams Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Carolina Cristina Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Damasia Becú-Villalobos Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Mark Jorissen Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Vincent Vander Poorten Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Marie Bex Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Johannes van Loon Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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Hugo Vankelecom Department of Development and Regeneration, Department of Hand Surgery, Zhejiang Provincial Key Laboratory of Ophthalmology, Eye Center of the 2nd Affiliated Hospital, Department of Imaging and Pathology, CITNOBA (National Research Council of Argentina), Laboratory of Pituitary Regulation, Unit Head and Neck Oncology, Research Group Experimental Oto‐Rhino‐Laryngology, Unit Clinical and Experimental Endocrinology, Research Group Experimental Neurosurgery and Neuroanatomy, Cluster Stem Cell Biology and Embryology, Research Unit of Stem Cell Research, KU Leuven (University of Leuven), Campus Gasthuisberg O&N4, Herestraat 49, B-3000 Leuven, Belgium

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  DLL3 Delta-like 3 ( Drosophila ) C   DLL4 Delta-like 4 ( Drosophila ) A   HES1 Hes family bHLH transcription factor 1 A   HES2 Hes family bHLH transcription factor 2 A   HES5 Hes family bHLH transcription factor 5 A   HEYL Hes-related family bHLH

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Clarissa Wormsbaecher Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

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Brittney M Cumbia The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

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Emma G Amurgis The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

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Jillian M Poska Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

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Madeline R Price Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

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Xiaokui M Mo Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA

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Sue E Knoblaugh Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA

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Takeshi Kurita The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA

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Craig Joseph Burd Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA

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day (E) 11.5–E14.5) is most susceptible to bisphenol A (BPA)-induced phenotypes. Observations in DES-exposed daughters suggest that first-trimester exposures to endocrine disrupting compounds (EDCs) are most critical for cancer risk in line with the 7

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Rengyun Liu Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA

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Mingzhao Xing Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA

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-year-old man, in whom thyroidectomy revealed a 3.5 cm tumor with mixed PTCs and ATCs in the left thyroid lobe with extrathyroidal invasion and metastases in 11 out of 18 lymph nodes. Postsurgery imaging showed extensive metastases in the lungs. He died

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