Filter

Refine by collections

Refine by date

—

Refine by access

  • Print
  • Save

Search Results

You are looking at 81 - 90 of 169 items for :

  • Refine by access: All content x
Clear All
Sunita K Agarwal Metabolic Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

Search for other papers by Sunita K Agarwal in
Google Scholar
PubMed Close

Transcriptional regulation Lemmens et al. (2001)  RUNX2 (BMP2 signaling) Transcriptional regulation Sowa et al. (2004)  SMADs (TGFβ signaling) (SMAD1, SMAD3, SMAD5) Transcriptional regulation Sowa et al. (2004)  SIRT1

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0199
Volume/Issue:
Volume 24: Issue 10
Free access
C Spitzweg Department of Internal Medicine IV, University Hospital of LMU Munich, Munich, Germany
Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA

Search for other papers by C Spitzweg in
Google Scholar
PubMed Close
,
P J Nelson Department of Internal Medicine IV, University Hospital of LMU Munich, Munich, Germany

Search for other papers by P J Nelson in
Google Scholar
PubMed Close
,
E Wagner Pharmaceutical Biotechnology, Department of Pharmacy, Centre for System-Based Drug Research, and Centre for Nanoscience, LMU Munich, Munich, Germany

Search for other papers by E Wagner in
Google Scholar
PubMed Close
,
P Bartenstein Department of Nuclear Medicine, University Hospital of LMU Munich, Munich, Germany

Search for other papers by P Bartenstein in
Google Scholar
PubMed Close
,
W A Weber Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany

Search for other papers by W A Weber in
Google Scholar
PubMed Close
,
M Schwaiger Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany

Search for other papers by M Schwaiger in
Google Scholar
PubMed Close
, and
J C Morris Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA
Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

Search for other papers by J C Morris in
Google Scholar
PubMed Close

/g) as compared to non-irradiated tumors (5.3 % ID/g) ( Schug et al. 2018 ). These data suggested that EBRT may not only enhance the migratory behavior of MSCs but may also act to potentially amplify activation of the TGFβ1-inducible SMAD

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-21-0177
Volume/Issue:
Volume 28: Issue 10
Free access
Zhenying Guo Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

Search for other papers by Zhenying Guo in
Google Scholar
PubMed Close
,
Heather Hardin Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

Search for other papers by Heather Hardin in
Google Scholar
PubMed Close
, and
Ricardo V Lloyd Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

Search for other papers by Ricardo V Lloyd in
Google Scholar
PubMed Close

proliferation. In ATC cells, NOTCH1 knockdown reduced miR-19. SMAD4 was validated as a miR-19 target by luciferase assay, which revealed reduced luminescence associated with miR-19–Smad4 3′-UTR interaction. Moreover, this effect was mimicked in PTC cells

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0002
Volume/Issue:
Volume 21: Issue 5
Free access
Annu Makker Post Graduate Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

Search for other papers by Annu Makker in
Google Scholar
PubMed Close
and
Madhu Mati Goel Post Graduate Department of Pathology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India

Search for other papers by Madhu Mati Goel in
Google Scholar
PubMed Close

its effect through heterotrimeric complex of transmembrane serine/threonine kinase, the type I (RI) and type II (RII) receptors. Following ligand binding, RI phosphorylates Smad2 and Smad3 (R-Smads). Phosphorylated R-Smads form a complex with Smad4 and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0218
Volume/Issue:
Volume 23: Issue 2
Free access
Claire E Fletcher Department of Surgery and Cancer, Cardiff University School of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Du Cane Road, London W12 0NN, UK

Search for other papers by Claire E Fletcher in
Google Scholar
PubMed Close
,
D Alwyn Dart Department of Surgery and Cancer, Cardiff University School of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Du Cane Road, London W12 0NN, UK
Department of Surgery and Cancer, Cardiff University School of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Du Cane Road, London W12 0NN, UK

Search for other papers by D Alwyn Dart in
Google Scholar
PubMed Close
, and
Charlotte L Bevan Department of Surgery and Cancer, Cardiff University School of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Du Cane Road, London W12 0NN, UK

Search for other papers by Charlotte L Bevan in
Google Scholar
PubMed Close

. 1993 ). Later it was shown that the C. elegans let7 gene product, also an ncRNA, could associate with the 3′-UTR of target genes to initiate a cascade of regulatory processes acting on heterochronic genes ( Reinhart et al . 2000 ). The

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0208
Volume/Issue:
Volume 21: Issue 5
Free access
Zhe Wang Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Zhe Wang in
Google Scholar
PubMed Close
,
Ke Ma Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Ke Ma in
Google Scholar
PubMed Close
,
Steffie Pitts Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Steffie Pitts in
Google Scholar
PubMed Close
,
Yulan Cheng Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Yulan Cheng in
Google Scholar
PubMed Close
,
Xi Liu Department of Pathology, The First Affiliated Hospital of Xi’ an Jiaotong University, Xi’ an, Shaanxi, China

Search for other papers by Xi Liu in
Google Scholar
PubMed Close
,
Xiquan Ke Department of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China

Search for other papers by Xiquan Ke in
Google Scholar
PubMed Close
,
Samuel Kovaka Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

Search for other papers by Samuel Kovaka in
Google Scholar
PubMed Close
,
Hassan Ashktorab Cancer Center, Howard University School of Medicine, Washington, District of Columbia, USA

Search for other papers by Hassan Ashktorab in
Google Scholar
PubMed Close
,
Duane T Smoot Department of Medicine, Meharry Medical College, Nashville, Tennessee, USA

Search for other papers by Duane T Smoot in
Google Scholar
PubMed Close
,
Michael Schatz Department of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

Search for other papers by Michael Schatz in
Google Scholar
PubMed Close
,
Zhirong Wang Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

Search for other papers by Zhirong Wang in
Google Scholar
PubMed Close
, and
Stephen J Meltzer Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Search for other papers by Stephen J Meltzer in
Google Scholar
PubMed Close

downregulation may enhance tumor cell proliferation, apoptosis and cell cycle progression by inhibiting miR-16’s target activity on the 3′-UTR of oncogenes such as Bcl-2, Smad3 and Yap-1 ( Cimmino et al . 2005 , Kang et al . 2015 , Zhang et al . 2018

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0478
Volume/Issue:
Volume 26: Issue 3
Free access
Sijin Li Department of Thyroid Surgery, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China

Search for other papers by Sijin Li in
Google Scholar
PubMed Close
,
Zhen Chen Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou, China

Search for other papers by Zhen Chen in
Google Scholar
PubMed Close
,
Mengchu Liu School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China

Search for other papers by Mengchu Liu in
Google Scholar
PubMed Close
,
Liang Li Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

Search for other papers by Liang Li in
Google Scholar
PubMed Close
,
Wensong Cai Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou, China

Search for other papers by Wensong Cai in
Google Scholar
PubMed Close
,
Zhe-Xiong Lian Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

Search for other papers by Zhe-Xiong Lian in
Google Scholar
PubMed Close
,
Haixia Guan Department of Endocrinology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

Search for other papers by Haixia Guan in
Google Scholar
PubMed Close
, and
Bo Xu Department of Thyroid Surgery, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China

Search for other papers by Bo Xu in
Google Scholar
PubMed Close

following gene sets: GCM_RAP2A ( Fig. 5C ), PID_SMAD2_3PATHWAY ( Fig. 5D ), and PID_WNT_CANONICAL_PATHWAY ( Fig. 5E ), which are associated with metastasis of certain cancers. Moreover, the CD39 lo PD-1 lo CD103 hi effector Tregs hi group upregulated the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0240
Volume/Issue:
Volume 31: Issue 3
Restricted access
W Solarek Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

Search for other papers by W Solarek in
Google Scholar
PubMed Close
,
A M Czarnecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

Search for other papers by A M Czarnecka in
Google Scholar
PubMed Close
,
B Escudier Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

Search for other papers by B Escudier in
Google Scholar
PubMed Close
,
Z F Bielecka Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland
Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

Search for other papers by Z F Bielecka in
Google Scholar
PubMed Close
,
F Lian Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

Search for other papers by F Lian in
Google Scholar
PubMed Close
, and
C Szczylik Laboratory of Molecular Oncology, School of Molecular Medicine, Institut Gustave Roussy, Emory University School of Medicine, Department of Oncology, Military Institute of Medicine, Szaserow 128, 04‐141 Warsaw, Poland

Search for other papers by C Szczylik in
Google Scholar
PubMed Close

Caki-2 cells. They also demonstrated that IGF1, through activation of Smad2 protein phosphorylation and its nuclear translocation, enhances TGF-β signaling, which in turn promotes IGFBP3 production. Such interconnection between IGFBP3 expression and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0135
Volume/Issue:
Volume 22: Issue 5
Free access
Avaniyapuram Kannan Murugan Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Search for other papers by Avaniyapuram Kannan Murugan in
Google Scholar
PubMed Close
,
Arasambattu Kannan Munirajan Department of Genetics, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India

Search for other papers by Arasambattu Kannan Munirajan in
Google Scholar
PubMed Close
, and
Ali S Alzahrani Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Search for other papers by Ali S Alzahrani in
Google Scholar
PubMed Close

more than 85% ( Fagin & Wells 2016 ). ATC is the most aggressive and deadly thyroid cancer accounting for less than 3% and its overall survival rate is only 3–5 months after initial diagnosis ( Fagin & Wells 2016 , Howlader et al. 2017 ). Currently

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0188
Volume/Issue:
Volume 25: Issue 2
Free access
Libero Santarpia Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of
Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of

Search for other papers by Libero Santarpia in
Google Scholar
PubMed Close
,
Milena Nicoloso Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of

Search for other papers by Milena Nicoloso in
Google Scholar
PubMed Close
, and
George A Calin Translational Research Unit, Endocrine Neoplasia and Hormonal Disorders, Experimental Therapeutics, Department of Oncology, Hospital of Prato and Istituto Toscana Tumori, Piazza dell' Ospedale, 59100 Prato, Italy Departments of

Search for other papers by George A Calin in
Google Scholar
PubMed Close

2 could be regulated by HMGA2, and that the regulation of Snail promoter by HMGA2 involves binding of this factor to Smad3 and Smad4 ( Thuault et al . 2008 ). In addition, RAS, which is another target of let-7 and a driving force for EMT, has

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0222
Volume/Issue:
Volume 17: Issue 1
Free access