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KeeMing Chia Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Heloisa Milioli Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Neil Portman Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Geraldine Laven-Law Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia

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Rhiannon Coulson Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Aliza Yong Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Davendra Segara St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Andrew Parker St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Catherine E Caldon Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Niantao Deng Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Alexander Swarbrick Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia

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Theresa E Hickey Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia

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Elgene Lim Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Darlinghurst, New South Wales, Australia

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been implicated in the pathogenesis of other malignancies such as ovarian teratocarcinoma ( Chung et al . 2014 ) and some subtypes of breast cancer ( Hickey et al . 2012 , Chia et al . 2015 ). Breast cancer is a highly heterogeneous disease

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0333
Volume/Issue:
Volume 26: Issue 2
Free access
Vanessa W Lim
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Jun Li
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Yinhan Gong
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Aizhen Jin Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore

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Jian-Min Yuan Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore
Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore

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Eu Leong Yong
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Woon-Puay Koh Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore
Department of Obstetrics and Gynaecology, National Registry of Diseases Office, Division of Cancer Control and Population Sciences, Department of Epidemiology, Duke-NUS Graduate Medical School Singapore, Saw Swee Hock School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228, Singapore

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Introduction There is ample experimental, epidemiological, and clinical evidence linking estrogens and breast cancer risk ( Henderson & Feigelson 2000 , Russo & Russo 2006 ). Several established risk factors for breast cancer are strongly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0233
Volume/Issue:
Volume 21: Issue 2
Free access
N Angelopoulos
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V Barbounis
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S Livadas
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D Kaltsas
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G Tolis
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Introduction Adjuvant therapy in breast cancer consists of hormonal therapy with or without chemotherapy given after surgical excision of the tumor. The goal of hormonal adjuvant treatment in early breast cancer is the inhibition

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00783
Volume/Issue:
Volume 11: Issue 3
Free access
Eva Baxter Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Karolina Windloch Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Greg Kelly Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Jason S Lee Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Frank Gannon Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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Donal J Brennan UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Dublin, Ireland
Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

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Introduction Over 1000 oestrogen-responsive genes have been identified in vitro , predominantly using the luminal breast cancer cell line MCF7, and these are involved in a variety of processes such as the cell cycle, proliferation and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0563
Volume/Issue:
Volume 26: Issue 1
Free access
P Kauraniemi
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A Kallioniemi
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Introduction The ERBB2 ( neu / HER2 ) oncogene, located at chromosome 17q12, is one of the most intensively studied genes in cancer, especially in breast cancer. ERBB2 encodes for a 185 kDa transmembrane glycoprotein that belongs

Article Type:
Review Article
DOI:
https://doi.org/10.1677/erc.1.01147
Volume/Issue:
Volume 13: Issue 1
Free access
Dennis H Dowhan Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Matthew J Harrison Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Natalie A Eriksson Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Peter Bailey Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Michael A Pearen Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Peter J Fuller Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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John W Funder Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Evan R Simpson Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Peter J Leedman Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Wayne D Tilley Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Melissa A Brown Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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Christine L Clarke Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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George E O Muscat Institute for Molecular Bioscience, School of Chemistry and Molecular Biosciences, Prince Henry's Institute for Medical Research, Laboratory for Cancer Medicine, Dame Roma Mitchell Cancer Research Laboratories, University of Sydney Western Clinical School, The University of Queensland, Brisbane, Queensland 4072, Australia

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vascular endothelial growth factor ( VEGF ( VEGFA )) and spleen tyrosine kinase ( SYK ) genes in MCF-7 and T-47D breast cancer cells ( Harrison et al . 2010 ). Initial studies have identified several PRMT proteins as having a key role in SHR

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0100
Volume/Issue:
Volume 19: Issue 4
Free access
T Nagahata
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T Sato
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A Tomura
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M Onda
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K Nishikawa
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M Emi
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Introduction One million women worldwide are diagnosed with breast cancer every year. Estrogen receptor (ER)-positive breast cancers generally have a better prognosis because adjuvant hormonal therapy with anti-estrogen reagents such

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00890
Volume/Issue:
Volume 12: Issue 1
Free access
P L Jeffery Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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R E Murray Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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A H Yeh Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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J F McNamara Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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R P Duncan Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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G D Francis Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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A C Herington Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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L K Chopin Ghrelin Research Group, Hormone-dependent Cancer Programme, School of Life Sciences, Queensland University of Technology, PO Box 2434, Brisbane 4001, Australia

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Introduction Breast cancer is the most commonly diagnosed malignancy in Western women ( Jemal et al. 2004 ) and is a significant cause of mortality and morbidity. Ovarian hormones and their receptors are essential for normal

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00984
Volume/Issue:
Volume 12: Issue 4
Free access
Gadi Shlomai Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA
The Dr Pinchas Borenstein Talpiot Medical Leadership Program 2013, Tel-Hashomer, Israel

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Zara Zelenko Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

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Irini Markella Antoniou Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

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Marilyn Stasinopoulos Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

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Aviva Tobin-Hess Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

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Michael P Vitek Cognosci, Inc., Durham, North Carolina, USA
Department of Neurology, Duke University Medical Center, Research Drive, Durham, North Carolina, USA

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Derek LeRoith Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

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Emily Jane Gallagher Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

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breast cancer incidence, metastases and recurrence ( Calle et al . 2003 , Stattin et al . 2007 , Giovannucci et al . 2010 , Campbell et al . 2012 , Tancredi et al . 2015 , Handelsman et al . 2016 ). Approximately 70% of obese women and almost

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0077
Volume/Issue:
Volume 24: Issue 10
Free access
Marc Lacroix
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Introduction Despite the improvements in detection and the treatment of breast cancer, about 40% of patients still succumb to the disease. The development of distant metastases is the major cause of these deaths. Breast cancer is

Article Type:
Review Article
DOI:
https://doi.org/10.1677/ERC-06-0001
Volume/Issue:
Volume 13: Issue 4
Free access