Filter

Refine by collections

Refine by date

—

Refine by access

  • Print
  • Save

Search Results

You are looking at 81 - 90 of 848 items for :

  • genetic alterations x
  • Refine by access: All content x
Clear All
Tanner Freeman Department of Pathology, UPMC, Pittsburgh, Pennsylvania, USA

Search for other papers by Tanner Freeman in
Google Scholar
PubMed Close
,
Charit Taneja Division of Endocrinology and Metabolism, UPMC, Pittsburgh, Pennsylvania, USA

Search for other papers by Charit Taneja in
Google Scholar
PubMed Close
,
N Paul Ohori Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by N Paul Ohori in
Google Scholar
PubMed Close
,
Abigail I Wald Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Abigail I Wald in
Google Scholar
PubMed Close
,
John Skaugen Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by John Skaugen in
Google Scholar
PubMed Close
,
Linwah Yip Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Linwah Yip in
Google Scholar
PubMed Close
,
Seungwon Kim Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Seungwon Kim in
Google Scholar
PubMed Close
,
Robert L Ferris Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
UPMC Hillman Cancer Center, Department of Oncology, Pittsburgh, Pennsylvania, USA

Search for other papers by Robert L Ferris in
Google Scholar
PubMed Close
,
Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Marina N Nikiforova in
Google Scholar
PubMed Close
,
Somak Roy Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Somak Roy in
Google Scholar
PubMed Close
, and
Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Search for other papers by Yuri E Nikiforov in
Google Scholar
PubMed Close

molecularly identified thyroidal metastasis of renal cell carcinoma and genetic alterations detected in FNAs by ThyroSeq testing. Case Age (y); gender Nodule size (cm) BCC Cytologic features a Multiple nodules USG History of RCC

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0195
Volume/Issue:
Volume 29: Issue 12
Restricted access
Jamie L Van Etten Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

Search for other papers by Jamie L Van Etten in
Google Scholar
PubMed Close
and
Scott M Dehm Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Department of Urology, University of Minnesota, Minneapolis, MN, USA

Search for other papers by Scott M Dehm in
Google Scholar
PubMed Close

Nowell in 1976 based on cytogenetic data ( Nowell 1976 ). In this early model, a cell of origin acquires genetic alterations that promote neoplasia. Further genetic instability fuels clonal expansion of “fit” clones that ultimately leads to advanced

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0049
Volume/Issue:
Volume 23: Issue 4
Free access
Andreas Venizelos K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

Search for other papers by Andreas Venizelos in
Google Scholar
PubMed Close
,
Hege Elvebakken Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

Search for other papers by Hege Elvebakken in
Google Scholar
PubMed Close
,
Aurel Perren Institute of Pathology, University of Bern, Bern, Switzerland

Search for other papers by Aurel Perren in
Google Scholar
PubMed Close
,
Oleksii Nikolaienko K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

Search for other papers by Oleksii Nikolaienko in
Google Scholar
PubMed Close
,
Wei Deng K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

Search for other papers by Wei Deng in
Google Scholar
PubMed Close
,
Inger Marie B Lothe Department of Pathology, Oslo University Hospital, Oslo, Norway

Search for other papers by Inger Marie B Lothe in
Google Scholar
PubMed Close
,
Anne Couvelard Department of Pathology, Université de Paris, Bichat Hospital, AP-HP, Paris, France

Search for other papers by Anne Couvelard in
Google Scholar
PubMed Close
,
Geir Olav Hjortland Department of Oncology, Oslo University Hospital, Oslo, Norway

Search for other papers by Geir Olav Hjortland in
Google Scholar
PubMed Close
,
Anna Sundlöv Departmentt of Oncology, Skåne University Hospital, Lund, Sweden
Department of Medical Radiation Physics, Lund University, Lund, Sweden

Search for other papers by Anna Sundlöv in
Google Scholar
PubMed Close
,
Johanna Svensson Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden

Search for other papers by Johanna Svensson in
Google Scholar
PubMed Close
,
Harrish Garresori Department of Oncology, Stavanger University Hospital, Stavanger, Norway

Search for other papers by Harrish Garresori in
Google Scholar
PubMed Close
,
Christian Kersten Department of Research, Hospital of Southern Norway, Kristiansand, Norway

Search for other papers by Christian Kersten in
Google Scholar
PubMed Close
,
Eva Hofsli Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Department of Oncology, St.Olavs Hospital, Trondheim, Norway

Search for other papers by Eva Hofsli in
Google Scholar
PubMed Close
,
Sönke Detlefsen Department of Pathology, Odense University Hospital, Odense, Denmark
Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

Search for other papers by Sönke Detlefsen in
Google Scholar
PubMed Close
,
Merete Krogh Department of Oncology, Odense University Hospital, Odense, Denmark

Search for other papers by Merete Krogh in
Google Scholar
PubMed Close
,
Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway

Search for other papers by Halfdan Sorbye in
Google Scholar
PubMed Close
, and
Stian Knappskog K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

Search for other papers by Stian Knappskog in
Google Scholar
PubMed Close

molecular mechanisms and genetic origin of these tumours as well as why these cancers are so aggressive. Importantly, we reveal a high fraction of targetable alterations in HG GEP-NEN patients, pointing to novel treatment strategies applying tailored

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0152
Volume/Issue:
Volume 29: Issue 1
Open access
William D Foulkes Departments of Human Genetics, Medicine and Oncology, McGill University, Montreal, Québec, Canada

Search for other papers by William D Foulkes in
Google Scholar
PubMed Close
,
Jérôme Bertherat Department of Endocrinology, Cochin Hospital, Paris Descartes University, Paris, France

Search for other papers by Jérôme Bertherat in
Google Scholar
PubMed Close
, and
Charis Eng Genomic Medicine Institute, Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences and Germline High Risk Focus Group, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Search for other papers by Charis Eng in
Google Scholar
PubMed Close

their US and Canadian collaborators ( Goudie et al. 2018 ) this complex and evolving field is efficiently summarized. It clearly shows that almost all endocrine glands have been found to possess genetic alterations in at least one tumor susceptibility

Article Type:
Editorial
DOI:
https://doi.org/10.1530/ERC-18-0283
Volume/Issue:
Volume 25: Issue 8
Free access
Adrian F Daly Department of Endocrinology Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

Search for other papers by Adrian F Daly in
Google Scholar
PubMed Close
and
Albert Beckers Department of Endocrinology Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart‐Tilman, 4000 Liège, Belgium

Search for other papers by Albert Beckers in
Google Scholar
PubMed Close

be a pentad ( Carney 2009 ). Carney triad has long been a puzzling entity, having all of the features of a genetic disease, including multiple rare tumor types occurring metachronously or synchronously in different organs and having particularly

Article Type:
Article Commentary
DOI:
https://doi.org/10.1530/ERC-14-0296
Volume/Issue:
Volume 21: Issue 4
Free access
Willem E Corver Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

Search for other papers by Willem E Corver in
Google Scholar
PubMed Close
and
Hans Morreau Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

Search for other papers by Hans Morreau in
Google Scholar
PubMed Close

Alterations as Genetic Drivers in Hürthle Cell Carcinoma’ Ganly et al . (2018) and Gopal et al . (2018) , respectively, defined alterations in oncogenic drivers and mitochondrial DNA mutations complex I (mtDNA), including the widespread whole

Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-18-0481
Volume/Issue:
Volume 26: Issue 3
Free access
M Montani
Search for other papers by M Montani in
Google Scholar
PubMed Close
,
A M Schmitt
Search for other papers by A M Schmitt in
Google Scholar
PubMed Close
,
S Schmid
Search for other papers by S Schmid in
Google Scholar
PubMed Close
,
T Locher
Search for other papers by T Locher in
Google Scholar
PubMed Close
,
P Saremaslani
Search for other papers by P Saremaslani in
Google Scholar
PubMed Close
,
P U Heitz
Search for other papers by P U Heitz in
Google Scholar
PubMed Close
,
P Komminoth
Search for other papers by P Komminoth in
Google Scholar
PubMed Close
, and
A Perren
Search for other papers by A Perren in
Google Scholar
PubMed Close

carcinoma. Journal of Molecular Medicine 81 819 –823. Khosla S , Patel VM, Hay ID, Schaid DJ, Grant CS, van Heerden JA & Thibodeau SN 1991 Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas

Article Type:
Research Article
DOI:
https://doi.org/10.1677/erc.1.00996
Volume/Issue:
Volume 12: Issue 4
Free access
Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK
NHS Nightingale Hospital London, London, UK

Search for other papers by Ashley K Clift in
Google Scholar
PubMed Close
and
Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

Search for other papers by Andrea Frilling in
Google Scholar
PubMed Close

-specific alterations in genetic landscape, protein expression, pathway activity or cell biology. Theoretically, it aims to minimise the ‘off-target’ adverse effects of pharmacological agents and maximise disease response by tailoring the strategy to the personal

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-20-0074
Volume/Issue:
Volume 27: Issue 9
Free access
Pamela Brock Divison of Human Genetics, Department of Internal Medicine and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA

Search for other papers by Pamela Brock in
Google Scholar
PubMed Close
,
Jennifer L Geurts Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

Search for other papers by Jennifer L Geurts in
Google Scholar
PubMed Close
,
Paulien Van Galen Hereditary Cancer Clinic and Hereditary Endocrine Clinic, Alberta Children’s Hospital, Calgary, Alberta, USA

Search for other papers by Paulien Van Galen in
Google Scholar
PubMed Close
,
Erica Blouch Center for Cancer Risk Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA

Search for other papers by Erica Blouch in
Google Scholar
PubMed Close
,
James Welch Metabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA

Search for other papers by James Welch in
Google Scholar
PubMed Close
,
Amy Kunz Allegheny Health Network Cancer Institute, Pittsburgh, Pennsylvania, USA

Search for other papers by Amy Kunz in
Google Scholar
PubMed Close
,
Lauren Desrosiers Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Lauren Desrosiers in
Google Scholar
PubMed Close
,
Jennifer Gauerke Center for Individualized Medicine, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA

Search for other papers by Jennifer Gauerke in
Google Scholar
PubMed Close
, and
Samuel Hyde Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Search for other papers by Samuel Hyde in
Google Scholar
PubMed Close

Introduction The goals of achieving a genetic diagnosis in the setting of hereditary endocrine neoplasia (HEN) syndromes include: to understand the basis for disease, provide anticipatory guidance for early detection (or prevention) of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0454
Volume/Issue:
Volume 27: Issue 8
Free access
Felix Haglund Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Felix Haglund in
Google Scholar
PubMed Close
,
Carl Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Carl Christofer Juhlin in
Google Scholar
PubMed Close
,
Taylor Brown Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Taylor Brown in
Google Scholar
PubMed Close
,
Mehran Ghaderi Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Mehran Ghaderi in
Google Scholar
PubMed Close
,
Tiantian Liu Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Tiantian Liu in
Google Scholar
PubMed Close
,
Adam Stenman Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Adam Stenman in
Google Scholar
PubMed Close
,
Andrii Dinets Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Andrii Dinets in
Google Scholar
PubMed Close
,
Manju Prasad Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Manju Prasad in
Google Scholar
PubMed Close
,
Reju Korah Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Reju Korah in
Google Scholar
PubMed Close
,
Dawei Xu Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Dawei Xu in
Google Scholar
PubMed Close
,
Tobias Carling Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Tobias Carling in
Google Scholar
PubMed Close
, and
Catharina Larsson Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska (CCK), Karolinska University Hospital, SE-171 76, Stockholm, Sweden

Search for other papers by Catharina Larsson in
Google Scholar
PubMed Close

telomerase activation is therefore expected to be caused by other mechanisms, which could include copy number alterations, DNA methylation, or other genetic and regulatory events. Declaration of interest The authors declare that there is no conflict of

Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-15-0121
Volume/Issue:
Volume 22: Issue 3
Open access