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Sonia M Abuzakhm
Sonia M Abuzakhm
OhioHealth, Columbus, Ohio, USA
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Vineeth Sukrithan
Vineeth Sukrithan
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
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Briant Fruth
Briant Fruth
Mayo Clinic, Rochester, Minnesota, USA
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Rui Qin
Rui Qin
Janssen Pharmaceuticals, Raritan, New Jersey, USA
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Jonathan Strosberg
Jonathan Strosberg
H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA
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Timothy J Hobday
Timothy J Hobday
Mayo Clinic, Rochester, Minnesota, USA
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Thomas Semrad
Thomas Semrad
Tahoe Forest Cancer Center, Truckee, California, USA
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Diane Reidy-Lagunes
Diane Reidy-Lagunes
Memorial Sloan Kettering Cancer Center, New York, New York, USA
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Hedy Lee Kindler
Hedy Lee Kindler
University of Chicago Medical Center, Chicago, Illinois, USA
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George P Kim
George P Kim
George Washington University Cancer Center, Washington, DC, USA
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Jennifer J Knox
Jennifer J Knox
Princess Margaret Cancer Centre, Toronto, ON, Canada
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Andreas Kaubisch
Andreas Kaubisch
Montefiore Medical Center, Bronx, New York, USA
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Miguel Villalona-Calero
Miguel Villalona-Calero
City of Hope, Duarte, California, USA
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Helen Chen
Helen Chen
CTEP National Cancer Institute, Bethesda, Maryland, USA
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Charles Erlichman
Charles Erlichman
Mayo Clinic, Rochester, Minnesota, USA
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Manisha H Shah
Manisha H Shah
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
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tract (also referred to as carcinoid tumors) typically behave in an indolent fashion, while high-grade neuroendocrine tumors are aggressive. In patients with unresectable or metastatic extra-pancreatic NETs, options for treatment are limited. Lanreotide
Marc Diedisheim
Marc Diedisheim
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Solène Dermine
Solène Dermine
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Anne Jouinot
Anne Jouinot
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Amandine Septier
Amandine Septier
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
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Sébastien Gaujoux
Sébastien Gaujoux
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Bertrand Dousset
Bertrand Dousset
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Digestive Surgery, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Guillaume Cadiot
Guillaume Cadiot
Department of Gastroenterology, Robert-Debré Hospital, Reims, France
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Etienne Larger
Etienne Larger
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Diabetology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Jérôme Bertherat
Jérôme Bertherat
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Raphael Scharfmann
Raphael Scharfmann
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
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Benoit Terris
Benoit Terris
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Pathology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Pathology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Romain Coriat
Romain Coriat
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Gastroenterology and Digestive Oncology, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Guillaume Assié
Guillaume Assié
Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR8104, F-75014, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France
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represent this family of fibrinogen genes with highly correlated expression. In univariate analysis, high grade tumors (grade 2, grade 3 and neuroendocrine carcinomas) (HR = 11.83, P = 0.001) and FGA expression (HR = 1.13, P = 0.005) were associated
Zane Hammoud
Zane Hammoud
Department of Obstetrics and Gynecology, Thoracic Surgery, Pathology, Indiana University School of Medicine, 975 West Walnut Street (IB360), Indianapolis, Indiana 46202-5121, USA Departments of
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Bailin Tan
Bailin Tan
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Sunil Badve
Sunil Badve
Department of Obstetrics and Gynecology, Thoracic Surgery, Pathology, Indiana University School of Medicine, 975 West Walnut Street (IB360), Indianapolis, Indiana 46202-5121, USA Departments of
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Robert M Bigsby
Robert M Bigsby
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, activating mutations in each of these signaling molecules have been shown to be more prevalent in lung adenocarcinomas found in women than in men ( Graziano et al . 1999 , Nelson et al . 1999 , Shigematsu & Gazdar 2006 ). A high percentage of human lung
J Hadoux
J Hadoux
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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D Malka
D Malka
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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D Planchard
D Planchard
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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J Y Scoazec
J Y Scoazec
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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C Caramella
C Caramella
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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J Guigay
J Guigay
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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V Boige
V Boige
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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S Leboulleux
S Leboulleux
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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P Burtin
P Burtin
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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A Berdelou
A Berdelou
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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Y Loriot
Y Loriot
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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P Duvillard
P Duvillard
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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C N Chougnet
C N Chougnet
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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D Déandréis
D Déandréis
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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M Schlumberger
M Schlumberger
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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I Borget
I Borget
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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M Ducreux
M Ducreux
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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E Baudin
E Baudin
Departments of Nuclear Medicine and Endocrine Tumors, Digestive Oncology, Medical Oncology (Thoracic Group), Pathology, Radiology, Centre Antoine Lacassagne, Department of Urologic Oncology, Department of Endocrinology, Department of Biostatistics and Epidemiology, Faculté de Médecine, Gustave Roussy, 114 Rue Edouard Vaillant, F-94800 Villejuif Cedex, France
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. 2010 , Panzuto et al . 2011 , Strosberg et al . 2011 ). These tumors, when located in the digestive system, are classified as WHO grade 3 NEC (G3-NEC), characterized by a poorly differentiated morphology, a mitotic count above 20/10 high-power field
Mieke E R Henfling
Mieke E R Henfling
Department of Molecular Cell Biology, GROW-School for Oncology & Developmental Biology, Maastricht University, Maastricht, The Netherlands
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Aurel A Perren
Aurel A Perren
Institute of Pathology, University of Bern, Bern, Switzerland
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Anja M Schmitt
Anja M Schmitt
Institute of Pathology, University of Bern, Bern, Switzerland
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Christiane M Saddig
Christiane M Saddig
Insulinoma and GEP-Tumor Center Neuss-Düsseldorf, Klinik für Endokrine Chirurgie, Lukaskrankenhaus Neuss, Germany
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Achim A Starke
Achim A Starke
Insulinoma and GEP-Tumor Center Neuss-Düsseldorf, Klinik für Endokrine Chirurgie, Lukaskrankenhaus Neuss, Germany
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Robert G Riedl
Robert G Riedl
Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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Yvonne M H Versleijen-Jonkers
Yvonne M H Versleijen-Jonkers
Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands
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Diana M Sprij-Mooij
Diana M Sprij-Mooij
Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Frans C S Ramaekers
Frans C S Ramaekers
Department of Molecular Cell Biology, GROW-School for Oncology & Developmental Biology, Maastricht University, Maastricht, The Netherlands
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Leo J Hofland
Leo J Hofland
Division of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Ernst-Jan M Speel
Ernst-Jan M Speel
Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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, (A) IGF2 (moderate (2) vs high (3) expression), (B) cytoplasmic IGF1R (low vs high expression), (C) cytoplasmic INSR (low vs high expression), (D) Grade (Grade1 vs Grade 2 + 3), (E) Disease (non-metastatic vs metastatic), (F) Tumor size (<2 cm vs ≥2
Jennifer A Chan
Jennifer A Chan
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David P Ryan
David P Ryan
Department of Medical Oncology, Department of Hematology/Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
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Andrew X Zhu
Andrew X Zhu
Department of Medical Oncology, Department of Hematology/Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
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Thomas A Abrams
Thomas A Abrams
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Brian M Wolpin
Brian M Wolpin
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Paige Malinowski
Paige Malinowski
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Eileen M Regan
Eileen M Regan
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Charles S Fuchs
Charles S Fuchs
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Matthew H Kulke
Matthew H Kulke
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histologically documented, locally unresectable or metastatic carcinoid or pancreatic neuroendocrine tumors of low grade or intermediate histological grade. Patients with poorly differentiated or high-grade neuroendocrine carcinomas were not eligible. Treatment
Mintallah Haider
Mintallah Haider
Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA
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Satya Das
Satya Das
Department of GI Oncology, Vanderbilt University, Nashville, Tennessee, USA
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Taymeyah Al-Toubah
Taymeyah Al-Toubah
Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA
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Eleonora Pelle
Eleonora Pelle
Department of Oncology, University of Bari, Bari, Puglia, Italy
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Ghassan El-Haddad
Ghassan El-Haddad
Moffitt Cancer Center, Department of Diagnostic Imaging and Interventional Radiology, Tampa, Florida, USA
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Jonathan Strosberg
Jonathan Strosberg
Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA
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not reached in the PRRT arm (hazard ratio (HR) for disease progression or death 0.21, 95% CI, 0.13–0.33; P < 0.001). Response rates were 3% in the high-dose octreotide arm and 18% in the PRRT arm ( P < 0.001). In this analysis, grade 3
Claudio Festuccia
Claudio Festuccia
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Giovanni Luca Gravina
Giovanni Luca Gravina
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Paola Muzi
Paola Muzi
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Roberto Pomante
Roberto Pomante
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Luca Ventura
Luca Ventura
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Robert L Vessella
Robert L Vessella
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Carlo Vicentini
Carlo Vicentini
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Mauro Bologna
Mauro Bologna
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moderate disorganization and a modest degree of stromal invasion (Gleason scores of 7); and group III consisted of poorly differentiated tumors showing high levels of disorganization and stromal invasion (Gleason of 8–10). Considering that the Gleason grade
Anna Koumarianou
Anna Koumarianou
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Stavroula Antoniou
Stavroula Antoniou
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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George Kanakis
George Kanakis
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Nikolaos Economopoulos
Nikolaos Economopoulos
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Dimitra Rontogianni
Dimitra Rontogianni
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Anastasios Ntavatzikos
Anastasios Ntavatzikos
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Nikolaos Tsavaris
Nikolaos Tsavaris
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Dimitrios Pectasides
Dimitrios Pectasides
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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George Dimitriadis
George Dimitriadis
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Gregory Kaltsas
Gregory Kaltsas
Medical Oncology Unit, Endocrine Unit, MRI Unit, Pathology Department, Fourth Department of Surgery, Medical Oncology Unit, Second Department of Internal Medicine Propaedeutic, Attikon University General Hospital, Rimini 1, 12462 Athens, Greece
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Dear Editor Neuroendocrine tumours (NETs) are highly vascularised tumours that express high levels of the vascular endothelial growth factor (VEGF) ligand together with its receptor VEGFR ( Modlin et al . 2008 ). Although advanced NETs may exhibit
Kimberly Kamp
Kimberly Kamp
Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine
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Brenda Gumz
Brenda Gumz
Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine
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Richard A Feelders
Richard A Feelders
Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine
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Dik J Kwekkeboom
Dik J Kwekkeboom
Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine
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Gregory Kaltsas
Gregory Kaltsas
Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine
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Frederico P Costa
Frederico P Costa
Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine
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Wouter W de Herder
Wouter W de Herder
Sector of Endocrinology, Department of Nuclear Medicine, Centro de Oncologia, Department of Pathophysiology, Department of Internal Medicine
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-differentiated (WHO grades 1 and 2) GEP-NETs with progressive disease (PD), with a well-established safety profile ( Yao et al . 2008 , 2010 , 2011 , Pavel et al . 2011 ). In the randomized phase III RADIANT-3 study, everolimus therapy was associated with a 2
