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Emelyne Dejeux, Robert Olaso, Bertrand Dousset, Anne Audebourg, Ivo G Gut, Benoit Terris, and Jörg Tost

-functioning tumors based on their clinical manifestations. Functioning tumors are associated with clinical syndromes caused by inappropriate secretion of hormones such as gastrinomas and insulinomas, the latter being the most frequent islet cell tumor of the pancreas

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Katarina Edfeldt, Peyman Björklund, Göran Åkerström, Gunnar Westin, Per Hellman, and Peter Stålberg

( Schnirer et al . 2003 ). The tumors are neoplasms of peptide- and amine-producing cells. Some patients will develop the carcinoid syndrome due to excessive secretion of serotonin and other metabolites, which includes flushing, diarrhea, abdominal pain

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M Muşat, M Korbonits, B Kola, N Borboli, M R Hanson, A M Nanzer, J Grigson, S Jordan, D G Morris, M Gueorguiev, M Coculescu, S Basuand, and A B Grossman

Introduction Pituitary tumours account for 10–15% of all intracranial neoplasms. Despite extensive research, the pathogenesis of the majority of pituitary adenomas remains to be clarified. Deregulation of various cell-cycle pathways

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Lautaro Zubeldía-Brenner, Catalina De Winne, Sofía Perrone, Santiago A Rodríguez-Seguí, Christophe Willems, Ana María Ornstein, Isabel Lacau-Mengido, Hugo Vankelecom, Carolina Cristina, and Damasia Becu-Villalobos

Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms . Cell 66 649 – 661 . ( ) 10.1016/0092-8674(91)90111-B Espinoza I Miele L 2013 Notch inhibitors for cancer

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Sandra Valéria de Sá, Maria Lúcia Corrêa-Giannella, Márcio Carlos Machado, Jean Jorge S de Souza, Maria Adelaide Albergaria Pereira, Rosely Antunes Patzina, Sheila Aparecida Coelho Siqueira, Marcel Cerqueira César Machado, and Daniel Giannella-Neto

effects on the cell cycle, while the function of SSTR4 remains unknown ( Lamberts et al. 2002 ). Insulinomas are rare endocrine neoplasias that constitute the most frequent islet cell tumours, with an estimated incidence of four cases per one

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Sandra Rodríguez-Rodero, Elías Delgado-Álvarez, Agustín F Fernández, Juan L Fernández-Morera, Edelmiro Menéndez-Torre, and Mario F Fraga

hormones and include adrenal gland tumor (adrenocortical carcinoma, ACC), islet cell tumors (gastrinoma, VIPoma, glucagonoma, and somatostatinoma), neuroendocrine tumors (such as pheochromocytoma), parathyroid and thyroid carcinomas, among others. In the

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Giovanni Vitale, Alessandra Dicitore, Concetta Sciammarella, Sergio Di Molfetta, Manila Rubino, Antongiulio Faggiano, and Annamaria Colao

(GIP and GLP-1) secretion without any alteration in hepatic and peripheral insulin sensitivity. All five SSTR subtypes are variably expressed in human pancreatic islets, with a preferential expression of SSTR1 and 5 in beta-cells, and of SSTR2 in alpha-cells

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Andrea Frilling, Goran Åkerström, Massimo Falconi, Marianne Pavel, Jose Ramos, Mark Kidd, and Irvin Mark Modlin

syndrome has developed, 30–50% of patients already have metastases. Up to 80% of patients affected by MEN1 develop synchronous or metachronous pancreatic islet cell or duodenal tumors, of them gastrinomas in 54%, insulinomas in 18%, and nonfunctional tumors

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Cecilia Piani, Giulia M Franchi, Chiara Cappelletti, Marina Scavini, Luca Albarello, Alessandro Zerbi, Paolo Giorgio Arcidiacono, Emanuele Bosi, and Marco F Manzoni

Research 120 139 – 161 . McLean AM Fairclough PD 2005 Endoscopic ultrasound in the localisation of pancreatic islet cell tumours . Best Practice and Research. Clinical Endocrinology and Metabolism 19 177 – 193 . Oberg K 2003 Diagnosis and treatment

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Y M H Jonkers, S M H Claessen, A Perren, S Schmid, P Komminoth, A A Verhofstad, L J Hofland, R R de Krijger, P J Slootweg, F C S Ramaekers, and E-J M Speel

region have been reported in other neoplasms, including neuroendocrine tumors ( Dannenberg et al. 2000 , Figueiredo et al. 2000 , Garcia et al. 2002 ), schwannomas ( Warren et al. 2003 ), and enteropathy-type T-cell lymphomas ( Baumgärtner et