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Erin Gibbons Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Rochester Medical Center, Rochester, New York, USA
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA

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Briaunna M N Minor Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Rochester Medical Center, Rochester, New York, USA
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA

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Stephen R Hammes Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Rochester Medical Center, Rochester, New York, USA

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melanocytes, such as premelanosome protein (PMEL) and glycoprotein NMB (GPNMB) ( Kuhnen et al. 2001 , Zhe & Schuger 2004 , Klarquist et al. 2009 , Prizant et al. 2016 ). These melanocytic markers have been used in tissue samples to differentiate LAM

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-23-0102
Volume/Issue:
Volume 30: Issue 9
Free access
Pablo Valderrabano Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Laila Khazai Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Marino E Leon Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Zachary J Thompson Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Zhenjun Ma Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Christine H Chung Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Julie E Hallanger-Johnson Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Kristen J Otto Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Kara D Rogers Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Barbara A Centeno Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Bryan McIver Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Introduction Several molecular marker tests are available to refine the diagnosis of thyroid nodules with indeterminate cytology. Initially, these tests were classified as either ‘rule-in’ or ‘rule-out’ tests, depending on their ability to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-16-0512
Volume/Issue:
Volume 24: Issue 3
Free access
Iman Azimi The School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia
Mater Research Institute, The University of Queensland, Brisbane, Queensland, Australia
Translational Research Institute, Brisbane, Queensland, Australia

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Gregory R Monteith The School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia
Mater Research Institute, The University of Queensland, Brisbane, Queensland, Australia
Translational Research Institute, Brisbane, Queensland, Australia

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). These include the expression of the specific transcription factors Snail and Twist, expression of mesenchymal markers such as vimentin and N-cadherin, and loss of epithelial markers such as E-cadherin ( Tsai & Yang 2013 ). Indeed, the consequences of EMT

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0334
Volume/Issue:
Volume 23: Issue 11
Free access
Adel Mandl Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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James M Welch Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Gayathri Kapoor Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Vaishali I Parekh Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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David S Schrump Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA

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R Taylor Ripley Division of General Thoracic Surgery, Baylor College of Medicine, Houston, Texas, USA

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Mary F Walter NIDDK Clinical Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Jaydira Del Rivero Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA

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Smita Jha Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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William F Simonds Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Robert T Jensen Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Lee S Weinstein Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Jenny E Blau Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Sunita K Agarwal Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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al. 2005 ). Therefore, it is generally thought that thymic tumor development in MEN1 patients is dependent on other somatic molecular events rather than a second hit to the MEN1 gene, and its pathogenesis is largely unknown. The lack of knowledge

Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-21-0226
Volume/Issue:
Volume 28: Issue 11
Open access
Laura Sterian Ward Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo Street, Cidade Universitaria, Campinas, Sao Paulo 13083-887, Brazil

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the molecular approaches to thyroid tumor diagnosis. In addition, some of the molecular markers presented have been long studied, such as RAS, RET, PPARG/PAX8, PIK3CA, TP53, TSHR, PTEN, GNAS, CTNNB1, AKT1 , whereas others have recently emerged as

Article Type:
Editorial
DOI:
https://doi.org/10.1530/ERC-14-0407
Volume/Issue:
Volume 21: Issue 5
Free access
Alberto Ferlin
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Manuel Pengo
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Damiano Pizzol
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Umberto Carraro
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Anna Chiara Frigo Section of Clinical Pathology and Centre for Human Reproduction Pathology, Department of Environmental Medicine and Public Health, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy

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Carlo Foresta
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performed for two SNPs in the KITLG gene, rs995030 and rs4471514. The two markers were in strong LD ( D '>0.95 and r 2 >0.90) and in HWE both in controls and in cases. Table 1 Characteristics of testicular germ cell tumor cases and controls Cases ( n

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0340
Volume/Issue:
Volume 19: Issue 1
Free access
Kjell Oberg Department of Endocrine Oncology, University Hospital, Entrance 78, SE-751 85 Uppsala, Sweden

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various cell types of the neuroendocrine cell system can secrete products, such as peptides and biogenic amines that are tumour specific and may serve as markers for the diagnosis and follow-up of treatment. Some tumour markers may have prognostic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-10-0280
Volume/Issue:
Volume 18: Issue S1
Free access
Enzo Lalli Université Côte d’Azur, Valbonne, France
CNRS UMR7275, Valbonne, France
NEOGENEX CNRS International Associated Laboratory, Valbonne, France
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France

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Michaela Luconi Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy

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adenocarcinomas. Molecular determinants and markers of the first steps in the metastatic process Most of the knowledge about the molecular mechanisms driving metastatization and biomarkers of metastasis derives from the study of carcinomas, which are

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0440
Volume/Issue:
Volume 25: Issue 2
Free access
Anne Wierinckx
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Carole Auger
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Pauline Devauchelle
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Arlette Reynaud
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Pascale Chevallier
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Michel Jan
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Gilles Perrin
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Michelle Fèvre-Montange
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Catherine Rey
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Dominique Figarella-Branger
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Gérald Raverot
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Marie-Françoise Belin
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Joël Lachuer
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Jacqueline Trouillas
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diagnosis MRI Histological markers Molecular markers Invasion Proliferation Invasion Proliferation Dev Ki-67 > 1% Mitosis > 0.5 (‰) Nuclear PTTG P53 DCAMKL3 CRMP1 ADAMTS6 PTTG1 ASK CCNB1 AURKB CENPE PITX1 Pathological diagnosis Dev, development; (), number

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0062
Volume/Issue:
Volume 14: Issue 3
Free access
Jennifer L Bishop The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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Alastair Davies The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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Kirsi Ketola The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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Amina Zoubeidi The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6
The Vancouver Prostate Centre, Department of Urologic Sciences, 2660 Oak Street, Vancouver, British Columbia, Canada V6H‐3Z6

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A Efstathiou E Lin SH 2013 Molecular classification of prostate cancer progression: foundation for marker-driven treatment of prostate cancer . Cancer Discovery 3 849 – 861 . ( doi:10.1158/2159-8290.CD-12-0460 ). Lubik AA Gunter JH

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-15-0137
Volume/Issue:
Volume 22: Issue 3
Free access