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Alberto Cascón Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Lucía Inglada-Pérez Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Iñaki Comino-Méndez Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Aguirre A de Cubas Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Rocío Letón Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Jaume Mora Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Mónica Marazuela Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Juan Carlos Galofré Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Miguel Quesada-Charneco Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Mercedes Robledo Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain
Hereditary Endocrine Cancer Group, ISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Department of Pediatric Oncology, Endocrinology Division, Department of Endocrinology and Nutrition, Endocrinology Service, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

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Dear Editor: Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors that arise from the adrenal medulla or from the extra-adrenal sympathetic and parasympathetic paraganglia respectively. Now we know that more than 30% of

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Gergely Huszty Department of Surgery, Transplantation and Gastroenterology, Faculty of Medicine, Semmelweis University, Budapest, Hungary

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Peter Igaz Department of Endocrinology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary

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Dear Editor, We have read the recent article of Zhang et al. , published in the July 2023 issue of Endocrine-Related Cancer article ID e220354 , on the risk of complications after core needle biopsy of pheochromocytoma/paraganglioma

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Raquel G Martins IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Joana B Nunes IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Valdemar Máximo IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Paula Soares IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Joana Peixoto IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Telmo Catarino IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Teresa Rito IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Pedro Soares IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Luísa Pereira IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Manuel Sobrinho-Simões IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Ana Paula Santos IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Joana Couto IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Rui Henrique IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Joana Matos-Loureiro IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Paula Dias IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Isabel Torres IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Jorge Lima IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal
IPATIMUP (Institute of Pathology and Molecular Immunology of the University of Porto), Medical Faculty of the University of Porto, Department of Endocrinology, Department of Pathology, Department of Pathology, Rua Dr Roberto Frias s/n, 4200-465, Porto, Portugal

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Dear Editor We would like to report a genetic screening of SDHB , SDHC , SDHD and SDHAF2 genes (hereafter abbreviated to SDHx ) in patients with paragangliomas (PGL) and phaeochromocytomas (PCC) from northern Portugal. PGL and PCC are

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Elizabeth Grubbs Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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Daniel Halperin Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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Steven G Waguespack Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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Robert F Gagel Departments of Surgical Oncology, GI Medical Oncology, and Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas

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Overview The multiple endocrine neoplasia syndromes are a varied group of disorders that include multiple endocrine neoplasia types 1 and 2 (MEN 1, MEN 2), von Hippel-Lindau (VHL) disease , Carney complex (CC), hereditary pheochromocytoma/paraganglioma

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Judith Favier Université Paris Cité, Inserm UMR970 PARCC, Equipe Labellisée par la Ligue contre le cancer, Paris, France

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Roderick Clifton-Bligh Department of Endocrinology Royal North Shore Hospital, University of Sydney, Sydney, Australia

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The endocrine community has witnessed significant advances in the understanding and management of pheochromocytoma and paraganglioma, thanks to the continuous and unprecedented efforts of healthcare professionals and researchers worldwide. The 6th

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Ruth T Casey Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, UK
Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Benjamin G Challis Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Alison Marker Department of Histopathology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Deborah Pitfield Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK

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Heok K Cheow Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Ashley Shaw Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Soo-Mi Park Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, UK

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Helen L Simpson Department of Diabetes and Endocrinology, University College London Hospitals, NHS Foundation Trust, London, UK

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Eamonn R Maher Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, UK

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Dear Editor, We have read with great interest the recent article by Tufton and coworkers reporting on the risk of metastasis in patients with paraganglioma (PGL) tumours associated with germline SDHA mutations ( Tufton et al . 2017 ). Herein

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Hartmut P H Neumann Unit for Preventive Medicine, Department of Internal Medicine, University Medical Center, Albert‐Ludwigs‐University, Hugstetter Straße 55, D‐79106 Freiburg, Germany

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Wouter de Herder Unit for Preventive Medicine, Department of Internal Medicine, University Medical Center, Albert‐Ludwigs‐University, Hugstetter Straße 55, D‐79106 Freiburg, Germany

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puzzling Dutch paraganglioma family. He and his collaborators mapped the susceptibility gene locus to 11q23 and linked it to a gene encoding one of the four subunits of succinate dehydrogenase (mitochondrial complex II, SDHD), an enzyme that lies at the all

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Thibault Bahougne Service d’Endocrinologie et Diabétologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Institut des Neurosciences Cellulaires et Intégratives, CNRS (UPR 3212), Strasbourg, France

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Alessio Imperiale Service de Biophysique et de Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
ICube, UMR 7357 Université de Strasbourg/CNRS et FMTS, Faculté de Medécine, Strasbourg, France

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Gerlinde Averous Département de Pathologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

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Gerard Chabrier Service d’Endocrinologie et Diabétologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

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Nelly Burnichon Département de Génétique, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Descartes, PRES Sorbonne Paris Cité, Faculté de Médecine, Paris, France
INSERM, UMR970, Paris-Centre de Recherche Cardiovasculaire, Paris, France

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Anne Paule Gimenez-Roqueplo Département de Génétique, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
Université Paris Descartes, PRES Sorbonne Paris Cité, Faculté de Médecine, Paris, France
INSERM, UMR970, Paris-Centre de Recherche Cardiovasculaire, Paris, France
Centre Expert National COMETE-Cancer de la surrénale, Paris, France

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Nassim Dali-Youcef Laboratoire de Biochimie et de Biologie Moléculaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC)/CNRS/INSERM/Université de Strasbourg, Illkirch, France

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Rossella Libe Centre Expert National COMETE-Cancer de la surrénale, Paris, France
Endocrinology Department, Cochin Hospital, Paris, France
Département de Médecine Nucléaire et de Tumeurs Endocrines, Institut Gustave Roussy, Université Paris Sud, Villejuif, France

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Eric Baudin Département de Médecine Nucléaire et de Tumeurs Endocrines, Institut Gustave Roussy, Université Paris Sud, Villejuif, France

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Catherine Roy Service de Radiologie B, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

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Herve Lang Service d’Urologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

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Laurence Kessler Service d’Endocrinologie et Diabétologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

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Dear Editor, Pheochromocytoma (PHEO) and extra-adrenal paraganglioma (PGL) are neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and the autonomic nervous system, respectively. These neoplasms are malignant in

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David Taïeb Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France

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Christelle Fargette Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France

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Abhishek Jha Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Nuclear medicine as a component of precision medicine This article is a summary of a plenary lecture presented at the 6th International Symposium on Pheochromocytoma/Paraganglioma (20 October 2022, Prague, Czech Republic), which explored the

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Zhengping Zhuang Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA

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Chunzhang Yang Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Ales Ryska The Fingerland Department of Pathology, Charles University Medical Faculty Hospital, Hradec Kralove, Czech Republic

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Yuan Ji Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Yingyong Hou Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

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Sky D Graybill San Antonio Military Medical Center, Fort Sam Houston, Texas, USA

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Petra Bullova Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia

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Irina A Lubensky Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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Günter Klöppel Consultation Center for Pancreas and Neuroendocrine Tumors, Department of Pathology, Technical University Munich, Munich, Germany

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Dear Editor, Somatic hypoxia-inducible factor 2 alpha ( HIF2A ) mutations are responsible for a newly discovered syndrome of multiple paragangliomas (PGL) and duodenal somatostatinomas associated with polycythemia (Pacak–Zhuang syndrome

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