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Universitat Internacional de Catalunya (UIC), Barcelona, Spain
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Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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-operation, radiation therapy, pharmacological treatment and bilateral adrenalectomy (BADX). In contrast with the other options, BADX almost invariably leads to permanent correction of cortisol excess and, although it is associated with lifelong primary adrenal
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, Louiset et al . 2013 ), or primary pigmented nodular adrenal disease (PPNAD) that is frequently due to mutations of PRKAR1A ( Bertherat 2006 ). All of these conditions apart from the unilateral adrenal tumours can benefit from bilateral adrenalectomy
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Bilateral adrenalectomy Bilateral adrenalectomy is generally considered the treatment of choice for patients with overt CS due to PBMAH. This choice, when made, needs to be based on good clinical grounds supporting that the benefits outweigh the adverse
Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK
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Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK
Northern Ireland Biobank, Belfast Health and Social Care Trust, Belfast, UK
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( Fleseriu et al. 2021 , Valassi 2022 ). Mortality in CD has repeatedly been shown to be raised in relation to the general population and is largely due to cardiovascular events, and this persists despite cure of CD with bilateral adrenalectomy ( Fountas
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Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
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Endocrinology Department, “C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania
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cavernous sinus, proliferation markers, treatments (surgery, radiotherapy, chemotherapy and other systemic medical treatments, and bilateral adrenalectomy), and survival after the initial diagnosis; and for the metastases/PC the time between the initial
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programme. She developed bilateral phaeochromocytomas and underwent staged bilateral adrenalectomies at the age of 12 and 14 respectively. At the age of 16, she was discovered to have a 2.5 cm tail of pancreas pNET on routine surveillance imaging ( Fig. 1E
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severe co-morbidity). These therapeutic options include radiotherapy, bilateral adrenalectomy, and medical therapy. Each of these options has its limitations due to variable response rates and complications, and in each individual patient, the pros and
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hernia repair. The patient underwent bilateral adrenalectomies with pathology confirming pheochromocytoma. Germline genetic testing revealed the codon M918T point mutation in the RET proto-oncogene, consistent with a diagnosis of MEN2B. The patient
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management viewpoint, a delay of more than 15 years was observed between the age at which patients would present bilateral PHEO (and thus a definite adrenal insufficiency when treated by bilateral adrenalectomy) in Europe vs South America. This could be due
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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florid CS ( Gagliardi et al . 2009 ). Bilateral adrenalectomy (combined weight 130 g) was curative, but he died from recurrent sepsis. His siblings, aged 61 and 65 years, presented with early CS; whilst lacking a Cushingoid phenotype, they had