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Elena Valassi IIB-Sant Pau and Department of Endocrinology/Medicine, Hospital Sant Pau and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain
Universitat Internacional de Catalunya (UIC), Barcelona, Spain

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Frédéric Castinetti Department of Endocrinology, Aix Marseille University, AP-HM, INSERM, Marseille Medical Genetics, Marmara Institute, La Conception Hospital, Marseille, France

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Amandine Ferriere Department of Endocrinology, Diabetes and Nutrition, University of Bordeaux, Bordeaux, France

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Stylianos Tsagarakis Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece

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Richard A Feelders Erasmus Medical Center, Division of Endocrinology, Department of Internal Medicine, Rotterdam, The Netherlands

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Romana T Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Michael Droste Praxis für Endokrinologie Dr. med. Michael Droste, Oldenburg, Germany

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Christian J Strasburger Division of Clinical Endocrinology, Department of Medicine CCM, Charité-Universitätsmedizin, Berlin, Germany

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Dominique Maiter Service d’Endocrinologie et Nutrition, Cliniques universitaires Saint Luc, Brussels, Belgium

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Darko Kastelan Department of Endocrinology, University Hospital Zagreb, Zagreb, Croatia

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Philippe Chanson Institut National de la Santé et de la Recherche Médicale, U1185, Le Kremlin, Bicêtre, Paris, France

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Susan M Webb IIB-Sant Pau and Department of Endocrinology/Medicine, Hospital Sant Pau and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Frank Demtröder Zentrum für Endokrinologie, Diabetologie, Rheumatologie Dr. Demtröder & Kollegen, Dortmund, Germany

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Valdis Pirags Paula Stradiņa klīniskā universitātes slimnīca, Riga, Latvia

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Olivier Chabre Hospitalier Universitaire, Grenoble, France

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Holger Franz Lohmann & Birkner Health Care Consultimg GmbH, Berlin, Germany

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Alicia Santos IIB-Sant Pau and Department of Endocrinology/Medicine, Hospital Sant Pau and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, Barcelona, Spain
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Martin Reincke Medizinische Klinik UND Poliklinik IV, Campus Innestadt, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany

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-operation, radiation therapy, pharmacological treatment and bilateral adrenalectomy (BADX). In contrast with the other options, BADX almost invariably leads to permanent correction of cortisol excess and, although it is associated with lifelong primary adrenal

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Carole Guerin Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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David Taieb Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Giorgio Treglia Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Thierry Brue Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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André Lacroix Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Frederic Sebag Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Frederic Castinetti Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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, Louiset et al . 2013 ), or primary pigmented nodular adrenal disease (PPNAD) that is frequently due to mutations of PRKAR1A ( Bertherat 2006 ). All of these conditions apart from the unilateral adrenal tumours can benefit from bilateral adrenalectomy

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Dimitra A Vassiliadi Department of Endocrinology, Diabetes, and Metabolism, Evangelismos Hospital, Athens, Greece

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Stylianos Tsagarakis Department of Endocrinology, Diabetes, and Metabolism, Evangelismos Hospital, Athens, Greece

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Bilateral adrenalectomy Bilateral adrenalectomy is generally considered the treatment of choice for patients with overt CS due to PBMAH. This choice, when made, needs to be based on good clinical grounds supporting that the benefits outweigh the adverse

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Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Brian Herron Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Stephen Cooke Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Belfast Health and Social Care Trust, Belfast, UK

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Jayna Elizabeth Smyth Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Karen R Mullan Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Estelle G Healy Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK

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Jane Evanson Department of Radiology, Barts Health NHS Trust, London, UK

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Stephanie G Craig Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK

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Jacqueline A James Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK
Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK
Northern Ireland Biobank, Belfast Health and Social Care Trust, Belfast, UK

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Márta Korbonits Department of Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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( Fleseriu et al. 2021 , Valassi 2022 ). Mortality in CD has repeatedly been shown to be raised in relation to the general population and is largely due to cardiovascular events, and this persists despite cure of CD with bilateral adrenalectomy ( Fountas

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Perrine Raymond Endocrinology Department, CHRU de Brabois, Vandoeuvre Les Nancy, France

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Gérald Raverot Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, “Groupement Hospitalier Est” Hospices Civils de Lyon, Bron, France
Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France

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Mirela-Diana Ilie Inserm U1052, CNRS UMR5286, Claude Bernard Lyon 1 University, Cancer Research Center of Lyon, Lyon, France
Endocrinology Department, “C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania

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cavernous sinus, proliferation markers, treatments (surgery, radiotherapy, chemotherapy and other systemic medical treatments, and bilateral adrenalectomy), and survival after the initial diagnosis; and for the metastases/PC the time between the initial

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Samuel M O’Toole Department of Endocrinology, St Bartholomew’s Hospital, London, UK

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Anju Sahdev Department of Radiology, St Bartholomew’s Hospital, London, UK

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Satya Bhattacharya Department of Surgery, The Royal London Hospital, London, UK

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Roger Feakins Department of Histopathology, The Royal London Hospital, London, UK

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Evelien F Gevers Department of Paediatric Endocrinology, The Royal London Hospital, London, UK

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William M Drake Department of Endocrinology, St Bartholomew’s Hospital, London, UK

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programme. She developed bilateral phaeochromocytomas and underwent staged bilateral adrenalectomies at the age of 12 and 14 respectively. At the age of 16, she was discovered to have a 2.5 cm tail of pancreas pNET on routine surveillance imaging ( Fig. 1E

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R van der Pas Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, 's‐Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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W W de Herder Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, 's‐Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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L J Hofland Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, 's‐Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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R A Feelders Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, 's‐Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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severe co-morbidity). These therapeutic options include radiotherapy, bilateral adrenalectomy, and medical therapy. Each of these options has its limitations due to variable response rates and complications, and in each individual patient, the pros and

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Jessica L Geiger Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

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Simion I Chiosea Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

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Sue M Challinor Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

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Marina N Nikiforova Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

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Julie E Bauman Division of Hematology/Oncology, Department of Internal Medicine, University of Pittsburgh Cancer Institute, Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Pittsburgh Medical Center, Division of Molecular Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, 5150 Centre Avenue, 5th Floor, Pittsburgh, Pennsylvania, 15232, USA

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hernia repair. The patient underwent bilateral adrenalectomies with pathology confirming pheochromocytoma. Germline genetic testing revealed the codon M918T point mutation in the RET proto-oncogene, consistent with a diagnosis of MEN2B. The patient

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Frederic Castinetti Department of Endocrinology Aix Marseille University, CNRS UMR7286 La Conception Hospital, Hopitaux de Marseille, Marseille, France

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Ana Luiza Maia Thyroid Section, Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Mariola Peczkowska Department of Hypertension, Institute of Cardiology, Warsaw, Poland

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Marta Barontini Center for Endocrinological Investigations, Hospital de Ninos R Gutierrez, Buenos Aires, Argentina

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Kornelia Hasse-Lazar Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska Curie Memorial Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Thera P Links Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

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Rodrigo A Toledo Department of Endocrinology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil

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Sarka Dvorakova Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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Caterina Mian Operative Unit of the Endocrinology Department of Medicine (DIMED), University of Padova, Padova, Italy

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Maria Joao Bugalho Hospital de Santa Maria – CHLN, Lisboa, Portugal

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Stefania Zovato Department of Medicine (DIMED), University of Padova, Padova, Italy

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Maria Alevizaki Endocrine Unit Evgenideion Hospital and Department of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, Athens, Greece

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Andrei Kvachenyuk Institute of Endocrinology, Kiev, Ukraine

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Birke Bausch 2nd Department of Medicine, University Medical Centre, Albert Ludwigs University of Freiburg, Freiburg, Germany

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Paola Loli Department of Endocrinology, Ospedale Niguarda Cà Granda, Milan, Italy

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Simona R Bergmann Division of Endocrinology and Diabetology, Faculty of Medicine, Philipps University of Marburg, Marburg, Germany

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Attila Patocs Molecular Medicine Research Group, HSA-SE ‘Lendület’ Hereditary Endocrine Tumor Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary

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Marija Pfeifer Department of Endocrinology, University Medical Center Ljubljana, Ljubljana, Slovenia

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Josefina Biarnes Costa Hospital Universitari de Girona, Gerencia Territorial Girona, Institut Català de la Salut, Girona, Spain

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Ernst von Dobschuetz Department of Visceral Surgery, University Medical Centre, Albert Ludwigs University of Freiburg, Freiburg, Germany

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Claudio Letizia Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy

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Gerlof Valk Department of Internal Medicine, University Medical Centre Utrecht, Utrecht, Netherlands

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Marcin Barczynski Department of Endocrine Surgery, Third Chair of General Surgery, Jagiellonian University, Medical College, Krakow, Poland

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Malgorzata Czetwertynska Department of Endocrinology, Maria Sklodowska Curie Memorial Center and Institute of Oncology, Warsaw, Poland

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John T M Plukker Department of Surgery, University Medical Centre, Groningen, Netherlands

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Paola Sartorato Department of Internal Medicine, General Hospital, Montebelluna, Treviso, Italy

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Tomas Zelinka 3rd Department of Medicine, Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

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Petr Vlcek Department of Nuclear Medicine and Endocrinology, Second Faculty of Medicine, Charles University, Prague, Czech Republic

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Svetlana Yaremchuk Institute of Otolaryngology NAMS of Ukraine, Kiev, Ukraine

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Georges Weryha Department of Endocrinology, University Hospital, Nancy, France

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Letizia Canu Department of Experimental and Clinical Biomedical Sciences, Endocrinology Unit, University of Florence, Florence, Italy

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Nelson Wohllk Endocrine Section, Universidad de Chile, Hospital del Salvador, Santiago de Chile, Chile

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Frederic Sebag Department of Endocrine Surgery, Aix-Marseille University, La Conception Hospital, Marseille, France

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Martin K Walz Department of Surgery and Center of Minimally Invasive Surgery, Kliniken Essen-Mitte, Essen, Germany

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Charis Eng Genomic Medicine Institute, Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hartmut P H Neumann Section for Preventive Medicine, Department of Nephrology and General Medicine, University Medical Centre, Albert Ludwigs University of Freiburg, Freiburg, Germany

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management viewpoint, a delay of more than 15 years was observed between the age at which patients would present bilateral PHEO (and thus a definite adrenal insufficiency when treated by bilateral adrenalectomy) in Europe vs South America. This could be due

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Lucia Gagliardi Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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King-Hwa Ling Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Chung H Kok Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Joseph Carolan Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Peter Brautigan Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Rosalie Kenyon Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Richard J D'Andrea Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Mark Van der Hoek Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Christopher N Hahn Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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David J Torpy Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Hamish S Scott Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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florid CS ( Gagliardi et al . 2009 ). Bilateral adrenalectomy (combined weight 130 g) was curative, but he died from recurrent sepsis. His siblings, aged 61 and 65 years, presented with early CS; whilst lacking a Cushingoid phenotype, they had

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