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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, Erasmus MC & Erasmus MC Cancer Institute, ENETS Center of Excellence, GD Rotterdam, the Netherlands

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Günter Klöppel Department of Pathology, Technical University Munich, Trogerstrasse, Munich, Germany

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special collection of reviews, published in Endocrine-Related Cancer , discusses the spectrum of disorders associated with the neoplasms and hyperplasias of alpha and beta cells. First, we (Wouter de Herder and Günter Klöppel) reviewed the history of

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, Erasmus MC & Erasmus MC Cancer Institute, ENETS Center of Excellence, Rotterdam, the Netherlands

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Günter Klöppel Department of Pathology, Technical University Munich, Munich, Germany

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& Grozinsky-Glasberg S 2023 Emerging therapies for malignant insulinomas and glucagonomas . Endocrine-Related Cancer e230020 . ( https://doi.org/10.1530/ERC-23-0020 ) Anlauf M Schlenger R Perren A Bauersfeld J Koch CA Dralle H Raffel A

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Francesca Marini Fondazione FIRMO Onlus, Italian Foundation for the Research on Bone Diseases, Florence, Italy

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Francesca Giusti Donatello Bone Clinic, Villa Donatello Hospital, Sesto Fiorentino, Italy

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Maria Luisa Brandi Fondazione FIRMO Onlus, Italian Foundation for the Research on Bone Diseases, Florence, Italy
Donatello Bone Clinic, Villa Donatello Hospital, Sesto Fiorentino, Italy

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-Glasberg S 2023 Emerging therapies for advanced insulinomas and glucagonomas . Endocrine-Related Cancer 30 e230020 . ( https://doi.org/10.1530/ERC-23-0020 ) Alrezk R Hannah-Shmouni F & Stratakis CA 2017 MEN4 and CDKN1B mutations: the latest of the

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Wenzel M Hackeng Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

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Lodewijk A A Brosens Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands

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Koen M A Dreijerink Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Endocrinology, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, The Netherlands

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G Driessen A Peeters D Lawrence B Print C Peeters M Van Camp G 2020 PDX1 DNA methylation distinguishes two subtypes of pancreatic neuroendocrine neoplasms with a different prognosis . Cancers (Basel) 12 1461 . ( https://doi.org/10

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Krystallenia I Alexandraki Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Gregory A Kaltsas Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Simona Grozinsky-Glasberg Department of Endocrinology and Metabolism, Neuroendocrine Tumor Unit, ENETS Center of Excellence, Hadassah Medical Organization and Faculty of Medicine, the Hebrew University, Jerusalem, Israel

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the risk of developing solid tumors and pancreatic cancer ( Gong et al. 2014 ); its beneficial effect on insulinoma treatment may be added ( Zaitseva et al. 2016 ). Several alternative radionuclides are studied such as 125 I-GIP targeting

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Emanuel Christ Division of Endocrinology, Diabetology and Metabolism and Center of Endocrine Tumors, University Hospital of Basel, Basel, Switzerland

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Donato Iacovazzo Centre for Endocrinology, William Harvey Research Institute, Barts and London School of Medicine, Queen Mary University of London, London, United Kingdom

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and London School of Medicine, Queen Mary University of London, London, United Kingdom

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Aurel Perren Institute of Pathology, University of Bern, Bern, Switzerland

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gene are extremely common in the general population. Next-generation sequencing of a panel of cancer-related genes in a case of sporadic insulinomatosis highlighted the presence of somatic copy number variants affecting several tested genes, including

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Alaa Sada Department of Surgery, Division of Endocrinology, Division of Gastroenterology and Hepatology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

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Travis J McKenzie Department of Surgery, Division of Endocrinology, Division of Gastroenterology and Hepatology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

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Adrian Vella Department of Surgery, Division of Endocrinology, Division of Gastroenterology and Hepatology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

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Michael J Levy Department of Surgery, Division of Endocrinology, Division of Gastroenterology and Hepatology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

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Thorvardur R Halfdanarson Department of Surgery, Division of Endocrinology, Division of Gastroenterology and Hepatology, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

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00268-018-4628-4 ) Christ E Antwi K Fani M & Wild D 2020 Innovative imaging of insulinoma: the end of sampling? A review . Endocrine-Related Cancer 27 R79 – R92 . ( https://doi.org/10.1530/ERC-19-0476 ) Cunha AS Beau C Rault A

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