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R Michael Tuttle Endocrinology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Duan Li Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Fourat Ridouani Interventional Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Introduction For more than 40 years, the prevailing treatment paradigm for well-differentiated thyroid cancer endorsed total thyroidectomy, radioactive iodine therapy, and thyroid hormone suppressive therapy for most patients with papillary

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden

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Ozgur Mete Department of Pathology, University Health Network, Toronto, ON, Canada
Endocrine Oncology Site, Princess Margaret Cancer Centre, Toronto, ON, Canada
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

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Zubair W Baloch Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

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thyroid cancer is a multistep process involving both early driver changes as well as late event changes. The well-differentiated thyroid carcinomas (PTC and FTC) usually are BRAF - or RAS -driven ( Nikiforov 2004 , Cancer Genome Atlas Research Network

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Maria Riedmeier University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.

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Lester D R Thompson Head and Neck Pathology Consultations, Los Angeles, California, USA

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Carlos Augusto Fernandes Molina Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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Boris Decarolis Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Medical Faculty, Cologne, Germany

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Christoph Härtel University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.

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Paul-G Schlegel University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.
Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany

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Martin Fassnacht Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany
Department of Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany

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Verena Wiegering University Children’s Hospital, Department of Pediatric Hematology, Oncology and Stem cell transplantation, University of Wuerzburg, Wuerzburg, Germany.
Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Centre, Wuerzburg, Germany

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January 1987. The search strategy for PubMed was as follows: (‘child*’[Title/Abstract] OR ‘pediatric*’[Title/Abstract]) AND (‘cancer’[Title/Abstract] OR ‘carcinoma’[Title/Abs tract] OR ‘tumor’[Title/Abstract] OR ‘malign*’[Title/Abstract]) AND

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Chiara Villa Department of Neuropathology, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France
Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France

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Bertrand Baussart Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Neurosurgery, Hôpital Universitaire Pitié-Salpêtrière, APHP, Sorbonne Université, Paris, France

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Guillaume Assié Inserm U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes-Université de Paris, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin APHP, Paris, France

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Gerald Raverot Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO, "Groupement Hospitalier Est" Hospices Civils de Lyon, Bron, France
Lyon 1 University, Villeurbanne, France
Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon, Lyon, France

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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the nomenclature of pituitary adenomas in 2016 ( Asa et al. 2017 ) and the controversy that followed ( Ho et al. 2019 , 2020 , 2021 , 2022 ), the WHO and International Agency for Research on Cancer (IARC) opted for the combined definition of

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