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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Department of Oncology, St.Olavs Hospital, Trondheim, Norway
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Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Introduction High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are defined by the presence of neuroendocrine phenotype and a high proliferation rate (Ki-67 > 20%). The HG NEN entity consists of well
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differentiated/high-grade adenocarcinomas. Large cell carcinoma variants or tumors with mixed features of small cell or large cell carcinoma admixed with classical prostate adenocarcinoma are also observed in later stages of prostate cancer. The term
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Kvols LK North American Neuroendocrine Tumor Society (NANETS) 2010 The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomas . Pancreas 39 799 – 800 . ( https
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predictive of the presence of lymph node metastases and advanced stages of disease in univariate analysis in all types of ovarian carcinoma. Further to this, in high grade serous carcinoma (HGSC), DLK1 expression is related to worse overall and progression