Search Results

You are looking at 1 - 10 of 431 items for :

  • "oestrogen" x
  • Refine by access: All content x
Clear All
Habibur P Rahman Institute of Metabolism and Systems Research, University of Birmingham, Birmingham

Search for other papers by Habibur P Rahman in
Google Scholar
PubMed
Close
,
Johannes Hofland Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Search for other papers by Johannes Hofland in
Google Scholar
PubMed
Close
, and
Paul A Foster Institute of Metabolism and Systems Research, University of Birmingham, Birmingham
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Healthcare Partners, Birmingham, UK

Search for other papers by Paul A Foster in
Google Scholar
PubMed
Close

testosterone and the more biologically active dihydrotestosterone (DHT) and the predominant oestrogens are oestrone (E 1 ) and the more biologically active oestradiol (E 2 ). However, the ratio of the two hormones differs between the sexes significantly. In the

Restricted access
Eva Baxter Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Eva Baxter in
Google Scholar
PubMed
Close
,
Karolina Windloch Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Karolina Windloch in
Google Scholar
PubMed
Close
,
Greg Kelly Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Greg Kelly in
Google Scholar
PubMed
Close
,
Jason S Lee Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Jason S Lee in
Google Scholar
PubMed
Close
,
Frank Gannon Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Search for other papers by Frank Gannon in
Google Scholar
PubMed
Close
, and
Donal J Brennan UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Dublin, Ireland
Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

Search for other papers by Donal J Brennan in
Google Scholar
PubMed
Close

Introduction Over 1000 oestrogen-responsive genes have been identified in vitro , predominantly using the luminal breast cancer cell line MCF7, and these are involved in a variety of processes such as the cell cycle, proliferation and

Free access
Ninu Poulose Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, UK

Search for other papers by Ninu Poulose in
Google Scholar
PubMed
Close
,
Ian G Mills Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, UK
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK

Search for other papers by Ian G Mills in
Google Scholar
PubMed
Close
, and
Rebecca E Steele Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, UK

Search for other papers by Rebecca E Steele in
Google Scholar
PubMed
Close

). The prostate is also a target for oestrogens among which oestradiol-17β is considered the most potent inducer of prostatic proliferation and promotes epithelial-to-mesenchymal transition in benign prostatic epithelial cells ( Shi et al . 2017

Free access
Anthony Howell CRUK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK

Search for other papers by Anthony Howell in
Google Scholar
PubMed
Close

Background The critical role played by oestrogen in breast cancer has driven a huge amount of research into the development of hormonal therapies that are able to block oestrogen-mediated cell signalling. For more than 30 years

Free access
Douglas A Gibson Queen's Medical Research Institute, MRC Centre for Reproductive Health, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

Search for other papers by Douglas A Gibson in
Google Scholar
PubMed
Close
and
Philippa T K Saunders Queen's Medical Research Institute, MRC Centre for Reproductive Health, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

Search for other papers by Philippa T K Saunders in
Google Scholar
PubMed
Close

Introduction The tissues of the female reproductive tract (vagina, cervix, uterus and fallopian tube) are key targets for the action of oestrogens by virtue of their expression of oestrogen receptors (ERs). During a woman's reproductive years, these

Free access
Cindy M Staka Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, UK

Search for other papers by Cindy M Staka in
Google Scholar
PubMed
Close
,
Robert I Nicholson Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, UK

Search for other papers by Robert I Nicholson in
Google Scholar
PubMed
Close
, and
Julia M W Gee Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, UK

Search for other papers by Julia M W Gee in
Google Scholar
PubMed
Close

Introduction Oestrogen deprivation, achieved clinically in post-menopausal women using aromatase inhibitors or in premenopausal women using ovarian ablation or suppression with luteinizing hormone-releasing hormone superagonists, is

Free access
Akiko Ebata Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan
Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Akiko Ebata in
Google Scholar
PubMed
Close
,
Takashi Suzuki Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Takashi Suzuki in
Google Scholar
PubMed
Close
,
Kiyoshi Takagi Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Kiyoshi Takagi in
Google Scholar
PubMed
Close
,
Yasuhiro Miki Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Yasuhiro Miki in
Google Scholar
PubMed
Close
,
Yoshiaki Onodera Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Yoshiaki Onodera in
Google Scholar
PubMed
Close
,
Yasuhiro Nakamura Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Yasuhiro Nakamura in
Google Scholar
PubMed
Close
,
Fumiyoshi Fujishima Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Fumiyoshi Fujishima in
Google Scholar
PubMed
Close
,
Kazuyuki Ishida Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Kazuyuki Ishida in
Google Scholar
PubMed
Close
,
Mika Watanabe Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Mika Watanabe in
Google Scholar
PubMed
Close
,
Kentaro Tamaki Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan
Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Kentaro Tamaki in
Google Scholar
PubMed
Close
,
Takanori Ishida Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Takanori Ishida in
Google Scholar
PubMed
Close
,
Noriaki Ohuchi Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Noriaki Ohuchi in
Google Scholar
PubMed
Close
, and
Hironobu Sasano Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan
Departments of, Pathology, Surgical Oncology, Pathology and Histotechnology, Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, Japan

Search for other papers by Hironobu Sasano in
Google Scholar
PubMed
Close

to identify the possible molecular mechanisms related to the acquisition of invasive properties and subsequently to improve clinical outcome of early breast cancer patients. It is well known that oestrogens play important roles in the progression of

Free access
Debbie Clements
Search for other papers by Debbie Clements in
Google Scholar
PubMed
Close
,
Sarah L Asprey
Search for other papers by Sarah L Asprey in
Google Scholar
PubMed
Close
,
Thomas A McCulloch Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

Search for other papers by Thomas A McCulloch in
Google Scholar
PubMed
Close
,
Theresa A Morris Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

Search for other papers by Theresa A Morris in
Google Scholar
PubMed
Close
,
Susan A Watson Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

Search for other papers by Susan A Watson in
Google Scholar
PubMed
Close
, and
Simon R Johnson
Search for other papers by Simon R Johnson in
Google Scholar
PubMed
Close

cellular kinase governing proliferation and apoptosis ( Li et al . 2004 ). Although TSC occurs equally in men and women, angiomyolipoma is more common and larger in women and is thought to be oestrogen dependent. LAM also occurs almost exclusively in women

Free access
G P Risbridger Monash Institute of Reproduction and Development (Centre for Urological Research), Monash University, Melbourne, Victoria, Australia. gail.risbridger@med.monash.edu.au

Search for other papers by G P Risbridger in
Google Scholar
PubMed
Close
,
J J Bianco Monash Institute of Reproduction and Development (Centre for Urological Research), Monash University, Melbourne, Victoria, Australia. gail.risbridger@med.monash.edu.au

Search for other papers by J J Bianco in
Google Scholar
PubMed
Close
,
S J Ellem Monash Institute of Reproduction and Development (Centre for Urological Research), Monash University, Melbourne, Victoria, Australia. gail.risbridger@med.monash.edu.au

Search for other papers by S J Ellem in
Google Scholar
PubMed
Close
, and
S J McPherson Monash Institute of Reproduction and Development (Centre for Urological Research), Monash University, Melbourne, Victoria, Australia. gail.risbridger@med.monash.edu.au

Search for other papers by S J McPherson in
Google Scholar
PubMed
Close

Androgens are essential for stimulating normal development, growth and secretory activities of the prostate whereas oestrogens are generally regarded as inhibitors of growth. Evidence for the local synthesis of oestrogens includes the detection of aromatase mRNA and protein in the stroma of human non-malignant tissues and in malignant tissue, where it is detected in epithelial tumour cells. As well, aromatase activity was measured by biochemical assay and protein was detected in prostatic non-malignant and tumour cell lines. Taken together with the identification of direct oestrogenic actions on the prostate, these results suggest that alterations in local oestrogen synthesis may have significant consequences in malignancy of these organs. Genetically modified mouse models were studied in order to evaluate the action of oestrogens alone or in combination with androgens on the prostate gland. Hypogonadal (hpg) mice are deficient in gonadotrophins and androgens but showed direct proliferative responses to oestradiol. The responses were characterised by discrete lobe-specific changes including smooth-muscle regression, fibroblast proliferation, inflammation, and basal epithelial cell proliferation and metaplasia. The aromatase knockout (ArKO) mouse, deficient in oestrogens due to a non-functional aromatase enzyme, developed prostatic hyperplasia during the lifelong exposure to elevated androgens, however, no malignant changes were detected in the prostate at any time. In contrast, combined androgen and oestrogen treatment has been shown to induce prostatic dysplasia and adenocarcinoma. These results demonstrate that malignant changes to the prostate gland are dependent upon both androgenic and oestrogenic responses and that neither hormone alone is sufficient to evoke aberrant patterns of growth, resulting in malignancy.

Free access
Balaji Ramachandran Department of Molecular Oncology, Cancer Institute (W.I.A.), Adyar, Chennai, India

Search for other papers by Balaji Ramachandran in
Google Scholar
PubMed
Close

recognised to be highly influenced by oestrogen hormones that control proliferation, apoptosis, migration and metastasis ( King 1991 , Henderson & Feigelson 2000 , Ramachandran et al . 2011 ). The uterine cervix is also a part of the female reproductive

Free access