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Jaime Guevara-Aguirre Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador
Instituto de Endocrinología IEMYR, Quito, Ecuador
Maastricht University, Maastricht, The Netherlands

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Gabriela Peña Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Gabriel Pazmiño Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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William Acosta Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Jannette Saavedra Instituto de Endocrinología IEMYR, Quito, Ecuador

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Daniela Lescano Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Diego de Robles s/n y Pampite, Cumbayá, Quito, Ecuador

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Alexandra Guevara Instituto de Endocrinología IEMYR, Quito, Ecuador

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Antonio W D Gavilanes Maastricht University, Maastricht, The Netherlands

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& Bodmer WF 1996 The mutation rate and cancer . PNAS 93 14800 – 14803 . ( https://doi.org/10.1073/pnas.93.25.14800 ) Topacio BR Zatulovskiy E Cristea S Xie S Tambo CS Rubin SM Sage J Kõivomägi M & Skotheim JM 2019 Cyclin D-Cdk4

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Vera Chesnokova Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

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Shlomo Melmed Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

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et al. 2019 ). Activated npGH can affect MSC proliferation by triggering GHR internalization and nuclear translocation via STAT5 phosphorylation and initiation of cyclinD1 and cyclinD1/CDK4 to phosphorylate Rb and release E2F1, which, in turn

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