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gangrenous leg with an alcoholic extract of the pancreas with the idea to counteract the effects of adrenaline, because he believed in antagonism between adrenaline and insulin as a cause of diabetes. The treatment led to a 5-day improvement, but the patient
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together: necrolytic migratory erythema and the glucagonoma syndrome . Journal of General Internal Medicine 28 1525 – 1529 . ( https://doi.org/10.1007/s11606-013-2490-5 ) 23681843 He S Zeng W Geng S & Jia J 2021 Glucagonoma syndrome with
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tumours and investigated their origin. He suggested that the tumour cells, like those of normal islets of Langerhans, differentiate out of the duct epithelium, and therefore called these cells as nesidioblasts, referring to the Greek words ‘nesidion’ for
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2004 , Valente et al. 2018 ). In adults, most cases (approximately 90%) of EHH are secondary to a single insulinoma, a well-differentiated insulin-producing pancreatic neuroendocrine tumor. In about 5% of cases, EHH is secondary to an insulinoma
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Donatello Bone Clinic, Villa Donatello Hospital, Sesto Fiorentino, Italy
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but can develop within a genetic syndrome in 5–10% of cases ( Maggio et al. 2020 ). Insulinoma can manifest as multiple neoplasms in about 10% of patients, especially in the genetic forms. This tumor is commonly benign and well-differentiated, but
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Department of Endocrinology, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, The Netherlands
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-metastatic disease. Patients with aggressive insulinoma have lower survival compared to patients with indolent insulinoma: 5-year-survival has been reported to be 94.5–100% for indolent and 24–66.8% for aggressive disease ( Yu et al. 2017 , Camara-de-Souza et al
ENETS Center of Excellence, University Hospital Tübingen, Tübingen, Germany
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, HE) that express predominantly glucagon (B). (C) Only single cells are insulin positive. (D) The physiologic distribution of glucagon (alpha) and insulin (beta) cells is completely abrogated (green – glucagon, red – insulin, bar marks 20 µm
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resection ( Heidsma et al. 2021 ). A study including 1034 patients who underwent surgery for pNETs found that the rate of severe complications defined by Clavien–Dindo score ≥3 was 32.2% for pancreaticoduodenectomy, 19.5% for distal pancreatectomy, and 24.5
