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Kaylee B Punter Department of Biomedical and Medical Sciences, Queen’s University, Kingston, Canada

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Charles Chu Department of Biomedical and Medical Sciences, Queen’s University, Kingston, Canada

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Edmond Y W Chan Department of Biomedical and Medical Sciences, Queen’s University, Kingston, Canada

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GTPase, optic atrophy 1 (OPA1) ( Cipolat et al. 2004 ). Due to identification of OPA1 mutations linked to autosomal dominant optic atrophy ( Ban et al. 2010 ), the underlying regulation of this protein has been characterised at genetic, biochemical

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Francesca Ruggieri Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Katharina Jonas Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Manuela Ferracin Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

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Michael Dengler Division of Oncology, Medical University of Graz, Graz, Austria

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Vanessa Jӓger Division of Oncology, Medical University of Graz, Graz, Austria

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Martin Pichler Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria
Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany
Translational Oncology, University Hospital of Augsburg, Augsburg, Germany

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al. 2015 ). The best-studied metabolic alteration is the so-called aerobic glycolysis or ‘Warburg effect’ – first described by German biochemist Otto Warburg in 1920 ( Warburg et al. 1927 , Potter et al. 2016 ). In contrast to normal cells

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