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100 Years of the Warburg Effect and Endocrine Cancer x

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Mitochondrial dynamics and oxidative phosphorylation as critical targets in cancer

Kaylee B Punter

Kaylee B Punter Department of Biomedical and Medical Sciences, Queen’s University, Kingston, Canada

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Charles Chu

Charles Chu Department of Biomedical and Medical Sciences, Queen’s University, Kingston, Canada

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Edmond Y W Chan

Edmond Y W Chan Department of Biomedical and Medical Sciences, Queen’s University, Kingston, Canada

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with alterations in OXPHOS or mitochondrial metabolism genes ( Lahiguera et al. 2020 ). It was further dissected using high-grade serous ovarian cancer cells that the loss of homologous recombination shifted the burden towards PARP-dependent DNA