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David Taïeb Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France

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Christelle Fargette Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France

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Abhishek Jha Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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maximize the risk–benefit balance. Molecular imaging is a component of PM by complementing morphologic imaging in the diagnosis and staging of PPGL, providing predictive and prognostic biomarkers, and implementing therapeutic options. Nuclear medicine is

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Susan Richter Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse, Dresden, Germany

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Timothy J Garrett Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA

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Nicole Bechmann Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse, Dresden, Germany

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Roderick J Clifton-Bligh Cancer Genetics Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, St Leonards, Australia
Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia

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Hans K Ghayee Department of Internal Medicine, Division of Endocrinology, University of Florida College of Medicine and Malcom Randall VA Medical Center, Gainesville, Florida, USA

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, for example, enabled the simultaneous measurement of several amines with increased assay sensitivity for 3-methoxytyramine by LC-MS/MS (van Faassen et al. 2020). The use of such extended metabolite panels might identify further markers for patient

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Anne-Paule Gimenez-Roqueplo Université Paris Cité, PARCC, INSERM, Paris, France
Département de Médecine Génomique des Tumeurs et des Cancers, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France

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Mercedes Robledo Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Biomedical Research Networking Centre on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain

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Patricia L M Dahia Division of Hematology and Medical Oncology, Department Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas, USA
Mays Cancer Center at UTHSCSA, San Antonio, Texas, USA

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. From a molecular perspective, WHO experts report that germline mutations in SDHB confer the highest risk of metastasis and that mutations in ATRX , or SETD2 , high total somatic mutation burden, MAML3 fusion genes, altered WNT pathway, and TERT

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Arthur S Tischler Department of Pathology and Laboratory Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA

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Judith Favier Université Paris cité, Inserm UMR970 PARCC, Equipe Labellisée par la Ligue contre le cancer, Paris, France

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cultures raise particular questions about how studies should optimally be performed and how cytotoxicity should be assessed. Approaches range from monolayer culture and counting of cells stained for neuroendocrine markers, a method first used effectively a

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Paul Benjamin Loughrey Patrick G Johnston Centre for Cancer Research, Queen’s University, Belfast, UK
Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Federico Roncaroli Geoffrey Jefferson Brain Research Centre, Division of Neuroscience and Experimental Psychology, School of Medicine, Manchester University, Manchester, UK

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Estelle Healy Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Philip Weir Department of Neurosurgery, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Madhu Basetti Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Ruth T Casey Department of Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

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Steven J Hunter Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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coincidental. Succinate dehydrogenase (SDH) gene variants (collectively known as SDHx ) can associate with PPGL ( Baysal et al. 2000 ). The association of PitNET and PPGL in the setting of SDHx variant was established at the molecular level in 2012

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Francesca Amore Department Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Rachele Garella Department Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Alice Santi Department Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Daniele Guasti Department of Experimental and Clinical Medicine, Imaging Platform, University of Florence, Italy

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Serena Martinelli Department Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
ENS@T Center of Excellence, Florence, Italy

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Letizia Canu Department Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
ENS@T Center of Excellence, Florence, Italy

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Daniele Bani Department of Experimental and Clinical Medicine, Imaging Platform, University of Florence, Italy

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Jiri Neuzil Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic
School of Pharmacy and Medical Science, Griffith University, Southport, Queensland, Australia
Faculty of Science and 1st Medical Faculty, Charles University, Prague, Czech Republic

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Mario Maggi Department Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
ENS@T Center of Excellence, Florence, Italy

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Roberta Squecco Department Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Elena Rapizzi Department Experimental and Clinical Medicine, University of Florence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
ENS@T Center of Excellence, Florence, Italy

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markers of EMT, such as Twist1 , Snai1 , Snai2 and Vimentin , was significantly increased in SDHB-deficient cells ( Fig. 2C ), suggesting that these cells undergo a transcriptional reprogramming associated with an EMT phenotype. Membrane

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