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maximize the risk–benefit balance. Molecular imaging is a component of PM by complementing morphologic imaging in the diagnosis and staging of PPGL, providing predictive and prognostic biomarkers, and implementing therapeutic options. Nuclear medicine is
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Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia
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, for example, enabled the simultaneous measurement of several amines with increased assay sensitivity for 3-methoxytyramine by LC-MS/MS (van Faassen et al. 2020). The use of such extended metabolite panels might identify further markers for patient
Département de Médecine Génomique des Tumeurs et des Cancers, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
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Biomedical Research Networking Centre on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain
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Mays Cancer Center at UTHSCSA, San Antonio, Texas, USA
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. From a molecular perspective, WHO experts report that germline mutations in SDHB confer the highest risk of metastasis and that mutations in ATRX , or SETD2 , high total somatic mutation burden, MAML3 fusion genes, altered WNT pathway, and TERT
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cultures raise particular questions about how studies should optimally be performed and how cytotoxicity should be assessed. Approaches range from monolayer culture and counting of cells stained for neuroendocrine markers, a method first used effectively a
Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health & Social Care Trust, Belfast, UK
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coincidental. Succinate dehydrogenase (SDH) gene variants (collectively known as SDHx ) can associate with PPGL ( Baysal et al. 2000 ). The association of PitNET and PPGL in the setting of SDHx variant was established at the molecular level in 2012
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Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
ENS@T Center of Excellence, Florence, Italy
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Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
ENS@T Center of Excellence, Florence, Italy
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School of Pharmacy and Medical Science, Griffith University, Southport, Queensland, Australia
Faculty of Science and 1st Medical Faculty, Charles University, Prague, Czech Republic
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Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
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Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
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markers of EMT, such as Twist1 , Snai1 , Snai2 and Vimentin , was significantly increased in SDHB-deficient cells ( Fig. 2C ), suggesting that these cells undergo a transcriptional reprogramming associated with an EMT phenotype. Membrane