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100 Years of the Warburg Effect and Endocrine Cancer x

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MicroRNAs as regulators of tumor metabolism

Francesca Ruggieri

Francesca Ruggieri Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Katharina Jonas

Katharina Jonas Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria

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Manuela Ferracin

Manuela Ferracin Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

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Michael Dengler

Michael Dengler Division of Oncology, Medical University of Graz, Graz, Austria

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Vanessa Jӓger

Vanessa Jӓger Division of Oncology, Medical University of Graz, Graz, Austria

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Martin Pichler

Martin Pichler Division of Oncology, Medical University of Graz, Graz, Austria
Research Unit “Non-Coding RNAs and Genome Editing in Cancer”, Division of Oncology, Medical University of Graz, Graz, Austria
Department of Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany
Translational Oncology, University Hospital of Augsburg, Augsburg, Germany

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molecular mechanisms ( Fig. 3 ). This regulation depends on cell type, physiological conditions, and external factors. miRNAs are mainly transcribed by RNA polymerase II from intergenic, intronic, or polycistronic loci to long primary transcripts, called pri