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William R Doerfler Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Alyaksandr V Nikitski Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Elena M Morariu Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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N Paul Ohori Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Simion I Chiosea Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Michael S Landau Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Marina N Nikiforova Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Yuri E Nikiforov Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Linwah Yip Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennysylvania, USA

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Pooja Manroa Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA
Division of Endocrinology, University of Texas Medical Branch, Galveston, Texas, USA

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testing is being increasingly used in thyroid nodules with indeterminate cytology, including Hürthle cell nodules, to assist in the management of these patients ( Patel et al. 2018 , Steward et al. 2019 ). However, how the molecular markers of Hürthle

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-20-0435
Volume/Issue:
Volume 28: Issue 5
Restricted access
Justine Vanhevel Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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Lieve Verlinden Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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Stefanie Doms Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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Hans Wildiers UZ Leuven, General Medical Oncology and Multidisciplinary Breast Center, Leuven, Belgium

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Annemieke Verstuyf Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

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.jsbmb.2014.10.007 ) 25460302 So JY Lee HJ Smolarek AK Paul S Wang CX Maehr H Uskokovic M Zheng X Conney AH Cai L 2011 A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer . Molecular

Article Type:
Review Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0182
Volume/Issue:
Volume 29: Issue 2
Free access
James F H Pittaway Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Constantinos Lipsos Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Katia Mariniello Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Leonardo Guasti Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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.105422 ) Helman LJ Thiele CJ Marston Linehant W Nelkint BD Baylint SB Israel MA 1987 Molecular markers of neuroendocrine development and evidence of environmental regulation (CDNA cloning/differential hybridization/neuroendocrine) . PNAS 84 2336

Article Type:
Review Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0208
Volume/Issue:
Volume 28: Issue 12
Free access
Himisha Beltran Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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Francesca Demichelis Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy

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cells typically express classical neuroendocrine markers such as chromogranin, synaptophysin, INSM1, NSE, CD56 ( Epstein et al. 2014 ). It is important to note that expression of these neuroendocrine markers is sometimes observed in poorly

Article Type:
Review Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0140
Volume/Issue:
Volume 28: Issue 8
Free access
Andreas Venizelos K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Hege Elvebakken Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

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Aurel Perren Institute of Pathology, University of Bern, Bern, Switzerland

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Oleksii Nikolaienko K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Wei Deng K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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Inger Marie B Lothe Department of Pathology, Oslo University Hospital, Oslo, Norway

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Anne Couvelard Department of Pathology, Université de Paris, Bichat Hospital, AP-HP, Paris, France

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Geir Olav Hjortland Department of Oncology, Oslo University Hospital, Oslo, Norway

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Anna Sundlöv Departmentt of Oncology, Skåne University Hospital, Lund, Sweden
Department of Medical Radiation Physics, Lund University, Lund, Sweden

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Johanna Svensson Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden

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Harrish Garresori Department of Oncology, Stavanger University Hospital, Stavanger, Norway

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Christian Kersten Department of Research, Hospital of Southern Norway, Kristiansand, Norway

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Eva Hofsli Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
Department of Oncology, St.Olavs Hospital, Trondheim, Norway

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Sönke Detlefsen Department of Pathology, Odense University Hospital, Odense, Denmark
Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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Merete Krogh Department of Oncology, Odense University Hospital, Odense, Denmark

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Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway

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Stian Knappskog K.G. Jebsen Center for Genome-Directed Cancer Therapy, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Oncology, Haukeland University Hospital, Bergen, Norway

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have associated microsatellite instability (MSI) with improved prognosis ( La Rosa et al. 2012 , Sahnane et al. 2015 ). However, molecular markers for classification, treatment selection and prognosis for HG GEP-NEN are generally lacking. Some

Article Type:
Research Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0152
Volume/Issue:
Volume 29: Issue 1
Open access
Chi-Yu Kuo Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan

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Yuan-Ching Chang Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan

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Ming-Nan Chien Division of Endocrinology and Metabolism, Department of Internal Medicine, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan

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Jie-Yang Jhuang Department of Pathology, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan

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Yi-Chiung Hsu Department of Biomedical Sciences and Engineering, National Central University, Taoyuan City, Taiwan

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Shih-Yuan Huang Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan

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Shih-Ping Cheng Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan
Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan
Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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-0256 . Molecular signatures associated with SREBP1 modulation To elucidate the underlying mechanisms of SREBP1-facilitated cancer invasiveness, RNA-Seq analysis was performed to identify differentially expressed genes associated with SREBP1 modulation. As

Article Type:
Research Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0256
Volume/Issue:
Volume 29: Issue 2
Restricted access
J T W Kwon Department of Oncology, University of Oxford, Oxford, UK

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R J Bryant Department of Oncology, University of Oxford, Oxford, UK
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

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E E Parkes Department of Oncology, University of Oxford, Oxford, UK

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). Supplementary to this molecular profile, requirements include disease progression following conventional therapy and a lack of viable alternative treatment options. Anti-PD-1 checkpoint blockade in the context of MSI-H/dMMR tumours is proposed to enhance

Article Type:
Review Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0149
Volume/Issue:
Volume 28: Issue 8
Open access
Livia Lamartina Gustave Roussy, Department of Nuclear Medicine and Endocrine Oncology, Villejuif, France

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Nadège Anizan Department of Medical Physics, Gustave Roussy and University Paris Saclay, Villejuif, France

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Corinne Dupuy UMR 8200/9019 CNRS Paris-Saclay, Genome Integrity and Cancers, Gustave Roussy and University Paris Saclay, Villejuif, France

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Sophie Leboulleux Gustave Roussy, Department of Nuclear Medicine and Endocrine Oncology, Villejuif, France

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Martin Schlumberger Gustave Roussy, Department of Nuclear Medicine and Endocrine Oncology, Villejuif, France

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prolonged benefits. Molecular tumor biopsy analysis performed before and during vemurafenib treatment in three patients revealed a decrease in MAPK pathway transcriptional output and induction of thyroid-specific gene expression, suggesting that these two

Article Type:
Review Article
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Top-cited articles of 2023
DOI:
https://doi.org/10.1530/ERC-21-0024
Volume/Issue:
Volume 28: Issue 10
Free access