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L , 2014 Lanreotide in metastatic enteropancreatic neuroendocrine tumors . New England Journal of Medicine 371 224 – 233 . ( https://doi.org/10.1056/NEJMoa1316158 ) 25014687 Cardoso Filho Fde A Feitosa RG Fechine CO Matos CM Cardoso AL
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Department of Endocrinology, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, The Netherlands
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Introduction Insulinomas are neuroendocrine tumors that autonomously secrete insulin and usually arise within the pancreas. Insulinomas are uncommon tumors, with an incidence of 1–4 per million per year and are usually considered ‘benign’ or
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Donatello Bone Clinic, Villa Donatello Hospital, Sesto Fiorentino, Italy
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Introduction Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the neuroendocrine cells of the pancreas, accounting for 1–3% of all types of pancreatic tumors ( Bevere et al. 2023 ). They can be classified into two
ENETS Center of Excellence, University Hospital Tübingen, Tübingen, Germany
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glucagon-producing neuroendocrine tumors. History and histology The first well-documented cases of GCHN were published in 2006 by Martin Anlauf and colleagues in an article on microadenomatosis of the endocrine pancreas in patients with and without
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2004 , Valente et al. 2018 ). In adults, most cases (approximately 90%) of EHH are secondary to a single insulinoma, a well-differentiated insulin-producing pancreatic neuroendocrine tumor. In about 5% of cases, EHH is secondary to an insulinoma
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Introduction In 1926, Dr William J Mayo operated on a patient with hypoglycemia induced by metastatic pancreatic neuroendocrine tumor (pNET) which led to the first description of insulinoma ( Wilder et al. 1927 ). Although the first
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neoplasms of the neuroendocrine cell system ( Pearse 1974 , de Herder et al. 2016 ). Since 2000, the islet cell tumors are referred to by the world health organization (WHO) as pancreatic neuroendocrine neoplasms (PanNENs) ( Rindi et al. 2022 , Capella
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. In addition, neuroendocrine neoplasias, hyperplasias and other pathologies arising in the insulin- or glucagon-secreting beta and alpha cells, respectively, were discovered and characterized. Even in the last decade, new pathologies of these cells
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Journal of Physiology. Endocrinology and Metabolism 304 E711 – E723 . ( https://doi.org/10.1152/ajpendo.00304.2012 ) Orujov M Lai KK & Forse CL 2019 Concurrent adult-onset diffuse β-cell nesidioblastosis and pancreatic neuroendocrine tumor: A