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NHS Nightingale Hospital London, London, UK
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Introduction Neuroendocrine neoplasms (NEN) represent a heterogeneous class of tumours that arise from nigh ubiquitously dispersed neuroendocrine cells, which may be stratified into clinically meaningful sub-groups on the basis of their
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Molecular Biology Laboratory, Hospital La Conception, AP-HM, Marseille, France
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Introduction Neuroendocrine neoplasms (NENs) (comprising well-differentiated NENs ((G1 to G3) and poorly differentiated NECs ( Inzani et al. 2018 )) are a heterogeneous group of malignancies with various clinical presentations and evolution
Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Reina Sofia University Hospital, Córdoba, Spain
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Introduction Neuroendocrine neoplasms (NENs) represent a heterogeneous group of rare neoplasms, which originate from enterochromaffin cells that are located throughout the whole body. NENs located in the gastrointestinal tract and pancreas are
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-related neuroendocrine neoplasms (NENs) in Table 1 . Table 1 MEN syndromes and related neuroendocrine neoplasms. MEN syndromes-related NENs (chromosome location, gene, function) Site (estimated penetrance) Specific NEN MEN1 (11q13.1; MEN1
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Department of Oncology, St.Olavs Hospital, Trondheim, Norway
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Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Introduction High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are defined by the presence of neuroendocrine phenotype and a high proliferation rate (Ki-67 > 20%). The HG NEN entity consists of well
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Introduction Neuroendocrine neoplasms (NENs) are epithelial neoplasms that exhibit neuroendocrine differentiation, and they can arise from neuroendocrine cells, which are distributed widely throughout the body. NENs are relatively rare, with
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Molecular Medicine Program, University of Pavia, Pavia, Italy
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Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
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susceptibilities to SARS-CoV-2 infection and COVID-19 phenotypes ( Lee et al. 2020 b ). Neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of malignancies, showing various clinical behavior and response to treatment. Their clinical history can
Università Cattolica del Sacro Cuore, Rome, Italy
ENETS Center of Excellence, Neuroendocrine Tumour (NET) Center, Rome, Italy
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ENETS Center of Excellence, Neuroendocrine Tumour (NET) Center, Rome, Italy
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unattributable to any given organ if not tested for site-specific antigens (i.e. hormones or transcription factors) ( Fig. 1 ). Figure 1 The neuroendocrine neoplasm category. The neuroendocrine cancer is defined as neuroendocrine neoplasm (NEN), a category
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Introduction Neuroendocrine neoplasms (NENs), previously named ‘carcinoid’ tumours, most frequently occur in the gastrointestinal (GI) tract (54.5%) and have been an area of ongoing interest in the field of many different disciplines including
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includes the tumours that generate steroid hormones. The tumours of the first group are called neuroendocrine neoplasms (NENs) because of the marker proteins that they share with the neural cell system. These markers are synaptophysin and neuron