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Adam W Nelson Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK
Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK

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Wayne D Tilley Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK
Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK

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David E Neal Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK
Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK
Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK

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Jason S Carroll Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK
Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK

Department of Urology Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

Dame Roma Mitchell Cancer Research Laboratories Faculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, Australia

Department of Oncology University of Cambridge, Cambridge CB2 2QQ, UK

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Introduction Prostate cancer is the commonest, non-cutaneous cancer in men, affecting 214 per 1000 European men. It is the second commonest cause of cancer death, accounting for 15% of all male cancers in developed countries ( Heidenreich et al

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Matias Knuuttila Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland

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Arfa Mehmood Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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Jenni Mäki-Jouppila Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland

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Henrik Ryberg Center for Bone and Arthitis Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Pekka Taimen Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland

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Juha Knaapila Department of Urology, Turku University Hospital, Turku, Finland

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Otto Ettala Department of Urology, Turku University Hospital, Turku, Finland

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Peter J Boström Department of Urology, Turku University Hospital, Turku, Finland

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Claes Ohlsson Center for Bone and Arthitis Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Mikko S Venäläinen Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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Asta Laiho Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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Laura L Elo Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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Petra Sipilä Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland

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Sari I Mäkelä Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland
Functional Foods Forum, University of Turku, Turku, Finland

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Matti Poutanen Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Turku Center for Disease Modeling (TCDM), Institute of Biomedicine, University of Turku, Turku, Finland
Center for Bone and Arthitis Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Introduction Androgens play a crucial role in the normal development and growth of the prostate and the growth of prostate cancer. The prostate tissue is known for the local biosynthesis of dihydrotestosterone (DHT), which is the principal

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Joanna M Day
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Paul A Foster Oncology Drug Discovery and Women's Health Group, School of Clinical and Experimental Medicine, IPSEN, Medicinal Chemistry, Division of Diabetes, Endocrinology and Metabolism, and Sterix Ltd., Imperial College London, London W12 0NN, UK

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Helena J Tutill
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Fabien Schmidlin Oncology Drug Discovery and Women's Health Group, School of Clinical and Experimental Medicine, IPSEN, Medicinal Chemistry, Division of Diabetes, Endocrinology and Metabolism, and Sterix Ltd., Imperial College London, London W12 0NN, UK

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Christopher M Sharland Oncology Drug Discovery and Women's Health Group, School of Clinical and Experimental Medicine, IPSEN, Medicinal Chemistry, Division of Diabetes, Endocrinology and Metabolism, and Sterix Ltd., Imperial College London, London W12 0NN, UK

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Jonathan D Hargrave Oncology Drug Discovery and Women's Health Group, School of Clinical and Experimental Medicine, IPSEN, Medicinal Chemistry, Division of Diabetes, Endocrinology and Metabolism, and Sterix Ltd., Imperial College London, London W12 0NN, UK

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Nigel Vicker Oncology Drug Discovery and Women's Health Group, School of Clinical and Experimental Medicine, IPSEN, Medicinal Chemistry, Division of Diabetes, Endocrinology and Metabolism, and Sterix Ltd., Imperial College London, London W12 0NN, UK

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Barry V L Potter Oncology Drug Discovery and Women's Health Group, School of Clinical and Experimental Medicine, IPSEN, Medicinal Chemistry, Division of Diabetes, Endocrinology and Metabolism, and Sterix Ltd., Imperial College London, London W12 0NN, UK

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Michael J Reed
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Atul Purohit
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Introduction Treatment of hormone-dependent prostate cancer by androgen ablation is usually initially successful, reducing primary tumour burden and increasing 5-year survival rates. Currently, androgen ablation is achieved using orchidectomy

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Luke A Selth Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide 5000, Australia

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Wayne D Tilley Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide 5000, Australia

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Lisa M Butler Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide 5000, Australia

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in prostate cancer (PCa), thyroid cancer, neuroblastoma, and glioblastoma but acts as a tumor suppressor in ovarian and breast cancer (for review, see Cortez et al . (2011) ). Such dichotomy in respect to miRNA function in cancer is not uncommon and

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T M Murphy Prostate Cancer Research Group, Institute of Molecular Medicine, Trinity College Dublin, Ireland

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A S Perry Prostate Cancer Research Group, Institute of Molecular Medicine, Trinity College Dublin, Ireland

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M Lawler Prostate Cancer Research Group, Institute of Molecular Medicine, Trinity College Dublin, Ireland

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Introduction Prostate cancer represents a global public health problem. Worldwide, it is the second most common noncutaneous cancer in men, accounting for ∼10% of male cancers ( Parkin et al . 2005 ). Prostate cancer is the second leading cause of

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Renea A Taylor Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia

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Roxanne Toivanen Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia

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Gail P Risbridger Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia

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Introduction Prostate cancer is a major cause of morbidity and mortality in men around the world, being the most common solid tumor. In America, ∼6 out of every 50 men over the age of 50 will be diagnosed with prostate cancer in his lifetime. In

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Suresh Veeramani
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Ta-Chun Yuan
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Siu-Ju Chen
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Fen-Fen Lin
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Juliette E Petersen
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Syed Shaheduzzaman
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Shiv Srivastava
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Richard G MacDonald
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Ming-Fong Lin
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PAcP is a 100 kDa glycoprotein containing two subunits of approximately 50 kDa each. In the mid 1930s, Gutman and his colleagues made the noteworthy observation that the activity of PAcP is increased in the circulation of patients with prostate cancer

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Amy A Lubik Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia
Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Jennifer H Gunter Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Brett G Hollier Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Susan Ettinger Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Ladan Fazli Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Nataly Stylianou Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Stephen C Hendy Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Hans H Adomat Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Martin E Gleave Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Michael Pollak Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Adrian Herington Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Colleen C Nelson Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia
Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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factors insulin and IGF1 have been implicated in prostate cancer (PC) progression ( Pollak 2008 a , Lubik et al . 2011 ); however, the role of IGF2 is less well explored. IGF2 expression is elevated in ovarian, colorectal and breast cancer associated

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Marianna Volpert Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia

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Luc Furic Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia
Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Jinghua Hu Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
The School of Biological Sciences, Monash University, Clayton, Victoria, Australia

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Anne E O’Connor Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
The School of Biological Sciences, Monash University, Clayton, Victoria, Australia

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Richard J Rebello Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia

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Shivakumar Keerthikumar Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia
Computational Cancer Biology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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Jemma Evans The Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Physiology, Monash University, Clayton, Victoria, Australia

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D Jo Merriner Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
The School of Biological Sciences, Monash University, Clayton, Victoria, Australia

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John Pedersen Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia

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Gail P Risbridger Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia
Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Peter McIntyre Health Innovations Research Institute and School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia.

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Moira K O’Bryan Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
The School of Biological Sciences, Monash University, Clayton, Victoria, Australia

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Introduction Prostate cancer is the most common male cancer in Western societies and the third most common cause of cancer-related mortality ( Jemal et al. 2011 ). Localised prostate cancer is well managed clinically with a 5-year survival

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Tanya K Day
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Tina Bianco-Miotto Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia
Dame Roma Mitchell Cancer Research Laboratories, School of Paediatrics and Reproductive Health, School of Agriculture, Discipline of Medicine, Hanson Institute, Adelaide Prostate Cancer Research Centre, The University of Adelaide, Adelaide, South Australia, Australia

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Introduction Numerous diseases are associated with abnormal hormonal regulation including breast and prostate cancers. Breast cancer is a heterogeneous disease that can be classified in many ways. The most primary classification is by hormone

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