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Royal Free Hospital, Charité University Medicine Berlin, University of Warmia and Mazury, University of Texas MD Anderson Cancer Center, University Hospital, Department of Oncology of the First Faculty of Medicine and General Teaching Hospital, Robert‐Debré Hospital, Markey Cancer Center, Vall d'Hebron University Hospital, Western General Hospital, Università Cattolica del Sacro Cuore, Ipsen, Ipsen, Beaujon Hospital, Paris Diderot University, London, UK
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neoplasia; or previous cancer (except in situ cervical or uterine carcinoma or basal-cell skin carcinoma or other cancers treated with curative intent and disease-free for >5 years). Patients were eligible for the OLE study if attending a participating
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Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden
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/β. 177 Lu-octreotate therapy was enhanced by heat shock protein inhibition in the GOT1 xenograft First-generation Hsp90 inhibitors have been shown to sensitise cancer cells to radiation ( Dote et al. 2006 , Lauber et al. 2015 , Wang et al
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larger approach to care and should be offered to those at any point in their cancer journey. Hospice differs from palliative care since it provides care specifically at the end of life and in a place which a patient calls home, be it a private residence
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Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, São Paulo, Brazil
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Hospital Sírio-Libanês or at Instituto do Câncer do Estado de São Paulo were enrolled in this study. All patients provided written informed consent, and the study was approved by the ethics committees of both institutions (HSL2015-15 and NP762
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). KSR2 has been reported to play a role in many diseases including early onset obesity, metabolic syndrome, insulin resistance, non-small cell lung cancer, melanoma, endometrial cancer, and invasive ductal carcinoma of the breast. Potential targeted
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CEINGE Biotecnologie Avanzate Scarl, Naples, Italy
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Introduction Anaplastic thyroid cancer (ATC) is a rare, aggressive tumor that accounts for only 1% of all thyroid cancers, but it is responsible for about one-third of all deaths from thyroid cancer ( Fagin & Wells 2016 ). ATC originates from
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CEINGE Biotecnologie Avanzate Scarl, Naples, Italy
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for the induction of differentiation muscle genes ( Dentice et al. 2014 , Ambrosio et al. 2017 ). Modulation of deiodinase expression also occurs in several cancers vs their normal corresponding tissues ( Nappi et al. 2021 ). Increased
Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia
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Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
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Cancer Genetics Laboratory, Kolling Institute, Royal North Shore Hospital, Sydney, Australia
Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
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through the mitochondrial respiratory chain leads to increased reactive oxygen species (ROS) such as superoxides, which are known drivers of proliferation in various forms of cancer ( Bénit et al. 2022 ). Secondly, succinate accumulation inhibits several
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repair gene CHEK2 showed a homozygous mutation in BON-1. Finally, we studied other cancer-associated genes, by analysing the 127 mutated genes identified in the Tumor Cancer Genome Atlas (TCGA) Pan-Cancer effort. ( Kandoth et al . 2013 ) Out of these
Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK
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Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK
Department of Diabetes and Endocrinology, University College London Hospital, London, UK
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. 2016 ). Understanding of the pathogenesis of PCC/PGLs is incomplete, with limited ability to predict malignant potential and at present the response to conventional cancer therapies is disappointing. Approximately 30% of PCC/PGLs are associated with