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Jesús Morillo-Bernal Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior Investigaciones Científicas, and Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain

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Lara P Fernández Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior Investigaciones Científicas, and Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain
Molecular Oncology Group, IMDEA Food Institute, CEI UAM-CSIC, Madrid, Spain

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Pilar Santisteban Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior Investigaciones Científicas, and Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

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-specific proteins and differentiation markers is common in thyroid carcinogenesis. Indeed, several studies have reported the abnormal expression of thyroid-specific transcription factors in some thyroid carcinomas and propose that their deregulation is a pivotal

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Sasha R Howard Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Department of Paediatric Endocrinology, Barts Health NHS Trust, London, UK

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Sarah Freeston Whipps Cross Hospital, Barts Health NHS Trust, London, UK

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Barney Harrison Retired Endocrine Surgeon, Sheffield, UK

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Louise Izatt Department of Clinical and Cancer Genetics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Sonali Natu Department of Pathology, University Hospital of North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, UK

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Kate Newbold Department of Clinical Oncology, Royal Marsden Hospital Foundation Trust, London, UK

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Sabine Pomplun Department of Pathology, University College London Hospital NHS Foundation Trust, London, UK

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Helen A Spoudeas Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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Sophie Wilne Department of Paediatric Oncology, Nottingham University Hospital’s NHS Trust, Nottingham, UK

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Tom R Kurzawinski Department of Endocrine Surgery, University College London Hospitals NHS Foundation Trust, London, UK
Department of Paediatric Endocrine Surgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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Mark N Gaze Department of Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, UK
Department of Clinical Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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advised in these patients as they will require radioiodine therapy. Management of patients who will require specific radiation protection (for example pregnant mothers) should be by an experienced paediatric molecular radiotherapy service. Neck

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Victoria Byrd Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Ted Getz Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Roshan Padmanabhan Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hans Arora Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Charis Eng Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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longitudinal Molecular Mechanisms of Cancer study (protocol 8458-PTEN) with identified pathogenic germline mutations in the PTEN gene. From this cohort, we enrolled 17 individuals with a history of component cancers and 15 without a history of cancer. History

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Jaydira Del Rivero Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA

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Josh Mailman NorCal CarciNET Community, Oakland, California, USA

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Michael W Rabow Department of Internal Medicine, Division of Palliative Medicine, University of California, San Francisco, San Francisco, California, USA

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Jennifer A Chan Harvard Medical School, Program in Carcinoid and Neuroendocrine Tumors, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

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Sarah Creed Good Shepherd Community Care, Harvard Kennedy School, Natick, Massachusetts, USA

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Hagen F Kennecke Providence Cancer Institute Franz Clinic, Portland Providence Medical Center, Portland, Oregon, USA

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Janice Pasieka Department of Surgery, Section of General Surgery, University of Calgary, Cumming School of Medicine, Calgary, Canada

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Jennifer Zuar Department of Internal Medicine, Division of Geriatrics and Palliative Medicine, Alpert Medical School, Providence, Rhode Island, USA

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Simron Singh Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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Lauren Fishbein Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA

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part of palliation for SI-NET patients with MF. Other treatments for NETs, including telotristat ethyl, molecularly targeted agents, and peptide receptor radionuclide therapy, may delay the onset of MF. Still, their role in the acute symptomatic

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E Baudin Endocrine Oncology Unit, Imaging Department, Gustave Roussy, Villejuif, France

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J Capdevila Medical Oncology Department, Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), IOB Quirón-Teknon, Barcelona, Spain

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D Hörsch ENETS Center of Excellence, Zentralklinik Bad Berka GmbH, Bad Berka, Germany

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S Singh Division of Medical Oncology, University of Toronto, Sunnybrook Odette Cancer Center, Sunnybrook HSC, Toronto, Ontario, Canada

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M E Caplin Neuroendocrine Tumour Unit, Royal Free Hospital School of Medicine, London, UK

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E M Wolin Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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W Buikhuisen Department of Thorax Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands

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M Raderer Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria

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E Dansin Thoracic Oncology Unit, Centre Oscar Lambret, Lille, France

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C Grohe Department of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany

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D Ferone Neuroendocrine Tumour Unit, Department of Internal Medicine and Medical Specialties, University of Genova, Genova, Italy

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A Houchard Data and Insights Generation and Strategy, Ipsen, Boulogne-Billancourt, France

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X-M Truong-Thanh Medical Affairs, Ipsen, Boulogne-Billancourt, France

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D Reidy-Lagunes Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical Center, New York, New York, USA

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the SPINET Study Group
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the SPINET Study Group

score of 0 or 1. Patients were excluded if they had received previous SSA treatment, more than two lines of chemotherapy (cytotoxic, molecular targeted therapy, or interferon-alpha) for TCs/ACs, or chemotherapy in the 4 weeks before randomization, or if

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