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Jan P Dumanski Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Chiara Rasi Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Peyman Björklund Department of Surgical Sciences, Experimental Surgery, Uppsala University, Uppsala, Sweden

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Hanna Davies Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Abir S Ali Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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Malin Grönberg Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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Staffan Welin Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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Halfdan Sorbye Department of Oncology, Haukeland University Hospital, Bergen, Norway
Department of Clinical Science, University of Bergen, Bergen, Norway

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Henning Grønbæk Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark

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Janet L Cunningham Department of Neuroscience, Uppsala University, Uppsala, Sweden

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Lars A Forsberg Department of Immunology, Genetics and Pathology and SciLifeLab, Uppsala University, Uppsala, Sweden

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Lars Lind Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Erik Ingelsson Division of Cardiovascular Medicine, Department of Medicine, Stanford University, San Francisco, California, USA

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Peter Stålberg Department of Surgical Sciences, Endocrine Surgery, Uppsala University, Uppsala, Sweden

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Per Hellman Department of Surgical Sciences, Endocrine Surgery, Uppsala University, Uppsala, Sweden

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Eva Tiensuu Janson Department of Medical Sciences, Endocrine Oncology, Uppsala University, Uppsala, Sweden

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majority of patients have metastases already at diagnosis, but the 5-year survival is reported to be over 75%, despite the presence of distant metastases ( Janson et al . 1997 ). Patients usually present with unspecific clinical symptoms such as abdominal

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Varinder Jeet Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Gregor Tevz Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Brett Hollier Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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Colleen Nelson Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia

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YKL40 in promoting the migration and invasion of PCa cells in addition to tumourigenicity. Materials and methods Cell culture All cell lines were maintained in phenol red-free RPMI-1640 media supplemented with 5% foetal bovine serum (FBS; Life

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Konsta Kukkonen Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Bryn Autio-Kimura Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Hanna Rauhala Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Juha Kesseli Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland

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Matti Nykter Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Foundation for the Finnish Cancer Institute, Helsinki, Finland

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Leena Latonen Foundation for the Finnish Cancer Institute, Helsinki, Finland
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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Tapio Visakorpi Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Fimlab Laboratories Ltd, Tampere, Finland

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-SFM (Gibco/Thermo Fisher Scientific), except during the DHT stimulation experiments, for which they were cultured in phenol-red free RPMI-1640 (Lonza, Basel, Switzerland) supplemented with 5% V/V charcoal filtered FBS and 2 mM l -glut. EP156T cells were

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Rajeev Mishra Department of Biosciences, Manipal University Jaipur, Jaipur, Rajasthan, India

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Subhash Haldar Department of Biotechnology, Brainware University, Kolkata, India

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Surabhi Suchanti Department of Biosciences, Manipal University Jaipur, Jaipur, Rajasthan, India

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Neil A Bhowmick Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA
Department of Research, Greater Los Angeles Veterans Administration, Los Angeles, California, USA

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/histone modification. The tight oncogenic regulation suggests multiple mechanisms by which they can be subverted in the events leading to cancer. The addition of a methyl group (CH 3 ) at fifth carbon position of the cytosine ring of DNA, termed, 5-methylcytosine (5

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D Alwyn Dart
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Bradley Spencer-Dene Androgen Signalling Laboratory, Department of Histopathology, Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK

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Simon C Gamble
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Jonathan Waxman
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Charlotte L Bevan
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action of 5α-reductase enzymes on testosterone. Cellular responses to androgens are mediated by the androgen receptor (AR), a ligand-activated transcription factor and member of the nuclear receptor superfamily ( Gelmann 2002 ). In the absence of ligand

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Mina Sattari Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland

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Annika Kohvakka Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland

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Elaheh Moradi A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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Hanna Rauhala Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland

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Henna Urhonen Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland

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William B Isaacs The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

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Matti Nykter Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland

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Teemu J Murtola Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
Department of Urology, Tampere University Hospital, Tampere, Finland

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Teuvo L J Tammela Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
Department of Urology, Tampere University Hospital, Tampere, Finland

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Leena Latonen Foundation for the Finnish Cancer Institute, Helsinki, Finland
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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G Steven Bova Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland

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Juha Kesseli Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland

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Tapio Visakorpi Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
Fimlab Laboratories Ltd, Tampere University Hospital, Tampere, Finland

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coding genes and pseudogenes were derived from Ensemble 99 ( Yates et al. 2020 ) and the GENCODE ( https://www.gencodegenes.org ) basic annotation files, respectively. For manual curation, Integrative Genomics Viewer (IGV 2.5.0) was used to visualize

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Roberto Olmos Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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José Miguel Domínguez Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Sergio Vargas-Salas Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Lorena Mosso Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Carlos E Fardella Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Gilberto González Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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René Baudrand Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Francisco Guarda Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Felipe Valenzuela Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Eugenio Arteaga Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Pablo Forenzano Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Flavia Nilo Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Nicole Lustig Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Alejandra Martínez Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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José M López Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile

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Francisco Cruz Department of Radiology, School of Medicine Pontificia Universidad Católica de Chile

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Soledad Loyola Department of Radiology, School of Medicine Pontificia Universidad Católica de Chile

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Augusto Leon Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Nicolás Droppelmann Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Pablo Montero Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Francisco Domínguez Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Mauricio Camus Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Antonieta Solar Department of Anatomic Pathology, School of Medicine Pontificia Universidad Católica de Chile

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Pablo Zoroquiain Department of Anatomic Pathology, School of Medicine Pontificia Universidad Católica de Chile

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Juan Carlos Roa Department of Anatomic Pathology, School of Medicine Pontificia Universidad Católica de Chile

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Estefanía Muñoz Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Elsa Bruce Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Rossio Gajardo Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Giovanna Miranda Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Francisco Riquelme Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Natalia Mena Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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Hernán E González Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile

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. Ultrasound evaluation All thyroid nodules were evaluated by following the ACR TI-RADS ( Tessler et al. 2017 ) recommendations and classified into three risk groups: low (TI-RADS 1 to TI-RADS 3), intermediate (TI-RADS 4), and high (TI-RADS 5

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Takeshi Ujike Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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Motohide Uemura Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Department of Therapeutic Urologic Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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Atsunari Kawashima Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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Akira Nagahara Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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Kazutoshi Fujita Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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Yasushi Miyagawa Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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Norio Nonomura Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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were not significant ( Table 2 ). Table 1 Patient characteristics of all cases. Variables Negative biopsy Positive biopsy P value Number 108 145 Age (years) 67.5 (35–79) 71 (51–84) 0.0001 PSA (ng

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Philipp Y Maximov Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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Balkees Abderrahman Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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Ramona F Curpan Institute of Chemistry, Romanian Academy, Timisoara, Romania

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Yousef M Hawsawi Department of Genetics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Ping Fan Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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V Craig Jordan Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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.31.15_suppl.5 ) Gregory CW He B Johnson RT Ford OH Mohler JL French FS Wilson EM 2001a A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy . Cancer Research 61 4315

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Tobias Hofving Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Viktor Sandblom Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Yvonne Arvidsson Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Emman Shubbar Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Gülay Altiparmak Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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John Swanpalmer Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden

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Bilal Almobarak Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Anna-Karin Elf Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Viktor Johanson Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Erik Elias Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Erik Kristiansson Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden

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Eva Forssell-Aronsson Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden

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Ola Nilsson Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Cancer Center, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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al. 2001 ) and was cultured in RPMI1640 supplemented with 10% foetal bovine serum (FBS), 5 μg/mL insulin and 5 μg/mL transferrin. The P-STS cell line was a gift from Professor R Pfragner. It was established from the primary tumour, described as a

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