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Department of Clinical Science, University of Bergen, Bergen, Norway
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majority of patients have metastases already at diagnosis, but the 5-year survival is reported to be over 75%, despite the presence of distant metastases ( Janson et al . 1997 ). Patients usually present with unspecific clinical symptoms such as abdominal
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Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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YKL40 in promoting the migration and invasion of PCa cells in addition to tumourigenicity. Materials and methods Cell culture All cell lines were maintained in phenol red-free RPMI-1640 media supplemented with 5% foetal bovine serum (FBS; Life
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Foundation for the Finnish Cancer Institute, Helsinki, Finland
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Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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Fimlab Laboratories Ltd, Tampere, Finland
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-SFM (Gibco/Thermo Fisher Scientific), except during the DHT stimulation experiments, for which they were cultured in phenol-red free RPMI-1640 (Lonza, Basel, Switzerland) supplemented with 5% V/V charcoal filtered FBS and 2 mM l -glut. EP156T cells were
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Department of Research, Greater Los Angeles Veterans Administration, Los Angeles, California, USA
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/histone modification. The tight oncogenic regulation suggests multiple mechanisms by which they can be subverted in the events leading to cancer. The addition of a methyl group (CH 3 ) at fifth carbon position of the cytosine ring of DNA, termed, 5-methylcytosine (5
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action of 5α-reductase enzymes on testosterone. Cellular responses to androgens are mediated by the androgen receptor (AR), a ligand-activated transcription factor and member of the nuclear receptor superfamily ( Gelmann 2002 ). In the absence of ligand
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Department of Urology, Tampere University Hospital, Tampere, Finland
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Department of Urology, Tampere University Hospital, Tampere, Finland
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Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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Fimlab Laboratories Ltd, Tampere University Hospital, Tampere, Finland
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coding genes and pseudogenes were derived from Ensemble 99 ( Yates et al. 2020 ) and the GENCODE ( https://www.gencodegenes.org ) basic annotation files, respectively. For manual curation, Integrative Genomics Viewer (IGV 2.5.0) was used to visualize
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. Ultrasound evaluation All thyroid nodules were evaluated by following the ACR TI-RADS ( Tessler et al. 2017 ) recommendations and classified into three risk groups: low (TI-RADS 1 to TI-RADS 3), intermediate (TI-RADS 4), and high (TI-RADS 5
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Department of Therapeutic Urologic Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
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were not significant ( Table 2 ). Table 1 Patient characteristics of all cases. Variables Negative biopsy Positive biopsy P value Number 108 145 Age (years) 67.5 (35–79) 71 (51–84) 0.0001 PSA (ng
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.31.15_suppl.5 ) Gregory CW He B Johnson RT Ford OH Mohler JL French FS Wilson EM 2001a A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy . Cancer Research 61 4315
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Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden
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al. 2001 ) and was cultured in RPMI1640 supplemented with 10% foetal bovine serum (FBS), 5 μg/mL insulin and 5 μg/mL transferrin. The P-STS cell line was a gift from Professor R Pfragner. It was established from the primary tumour, described as a