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Gina Chia-Yi Chu Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Haiyen E Zhau Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Ruoxiang Wang Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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André Rogatko Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Xu Feng Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Majd Zayzafoon Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Youhua Liu Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Mary C Farach-Carson Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Sungyong You Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Jayoung Kim Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Michael R Freeman Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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Leland W K Chung Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of
Uro-Oncology Research, Surgery, Biomedical Sciences, Biostatistics and Bioinformatics Center, Department of Pathology, Department of Pathology, Department of Biochemistry and Cell Biology, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of

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). Receptor activator of NF-κB ligand (RANKL)–RANK signaling has many crucial physiological roles in bone and other tissues ( Hanada et al . 2009 ), and aberrant RANKL–RANK signaling in cancer and bone cells affects cancer bone colonization ( Dougall 2011

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Yong-Zi Chen Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Department of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China

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Youngchul Kim Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

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Hatem H Soliman Department of Women’s Oncology and Experimental Therapeutics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Department of Clinical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA

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GuoGuang Ying Department of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China

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Jae K Lee Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Department of Clinical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA

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cell lines for each of the four drugs. Several different statistical methods have been used for this analysis, including Pearson product–moment correlation, Spearman’s rank-order correlation, Welch’s two-sample t -test by grouping the cell line into

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Claire K Mulvey Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Alan Paciorek Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

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Farhana Moon Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Paige Steiding Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Brandon Shih Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA

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Matthew A Gubens Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Li Zhang Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

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Emily K Bergsland Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA

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Iona Cheng Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

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unspecified. The median (interquartile range) follow-up time for our lung NET cohort was 8.7 years (2.6-12.8). Statistical analysis Patient characteristics at diagnosis were compared by stage using the Wilcoxon rank sum test for continuous variables

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Catherine T Choy Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Haseong Kim Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Ji-Young Lee Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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David M Williams Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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David Palethorpe Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Greg Fellows Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Alan J Wright Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Ken Laing Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Leslie R Bridges Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Franklyn A Howe Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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Soo-Hyun Kim Division of Biomedical Sciences, Academic Neurosurgery Unit, Division of Clinical Sciences, Department of Cellular Pathology, Division of Cardiac and Vascular Sciences, Department of Electrical and Electronic Engineering, St George's Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

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and brain tumorigenesis. Subjects and methods Meta-analysis of public microarray data We used the rank-product method, which ranks the ratio of expression levels and tests the significance which is a product of the corresponding ranks. Normal (N), low

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Stefano Caramuta Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Linkiat Lee Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Deniz M Özata Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Pinar Akçakaya Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Hong Xie Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Anders Höög Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Jan Zedenius Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Martin Bäckdahl Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Catharina Larsson Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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Weng-Onn Lui Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden
Departments of Oncology-Pathology, Molecular Medicine and Surgery, Cancer Center Karolinska (CCK), Department of Breast and Endocrine Surgery, Karolinska Institutet, Stockholm, Sweden

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were compared using log-rank test. Overall survival was the period from the time of diagnosis until the end of follow-up or death of the patient. For overall survival analysis, survival was censored if patients were still alive at the end of the follow

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Deniz M Özata Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Stefano Caramuta Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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David Velázquez-Fernández Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Pinar Akçakaya Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Hong Xie Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Anders Höög Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Martin Bäckdahl Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Catharina Larsson Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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Weng-Onn Lui Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Department of Oncology‐Pathology, Department of Breast and Endocrine Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden

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with survival was studied using Kaplan–Meier plots, and the curves for each group were compared by log-rank test. All the analyses were two-tailed and P values <0.05 were considered significant. Results Deregulated miRNAs in ACC In this study, we

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Sung Gwe Ahn Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Chang Ik Yoon Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Jae Hoon Lee Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Hye Sun Lee Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea

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So Eun Park Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Yoon Jin Cha Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Chihwan Cha Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Soong June Bae Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Kyung-A Lee Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Joon Jeong Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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date of the first tumor recurrence, including loco-regional recurrence, distant metastasis or death. The Kaplan–Meier method was used to estimate the RFS, and the estimated survival curves were compared using the log-rank test. The Cox’s regression

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Jing Nie Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
Nanfang Neurosurgery Research Institution, Nanfang hospital, Southern Medical University, Guangzhou, China

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Guang-long Huang Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
Nanfang Neurosurgery Research Institution, Nanfang hospital, Southern Medical University, Guangzhou, China

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Sheng-Ze Deng Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Yun Bao Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Ya-Wei Liu Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
Nanfang Neurosurgery Research Institution, Nanfang hospital, Southern Medical University, Guangzhou, China

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Zhan-Peng Feng Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Chao-Hu Wang Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Ming Chen Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China

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Song-Tao Qi Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
Nanfang Neurosurgery Research Institution, Nanfang hospital, Southern Medical University, Guangzhou, China

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Jun Pan Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
Nanfang Neurosurgery Research Institution, Nanfang hospital, Southern Medical University, Guangzhou, China

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, version 11.5 (SPSS), using an unpaired t -test, one-way ANOVA analysis with post hoc Tukey’s test or Spearman’s rank correlation coefficient followed by simple main effect test. P  < 0.05 was considered statistically significant. Results

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Giulia Cantini Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
Istituto Nazionale Biostrutture e Biosistemi (I.N.B.B.), via delle Medaglie D’Oro, Rome, Italy

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Elena Niccolai Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Letizia Canu Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy

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Leandro Di Gloria Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy

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Simone Baldi Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Arianna Pia Propato Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
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Laura Fei Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
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Giulia Nannini Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Gabriella Nesi Department of Health Sciences, Pathology Section, University of Florence, Florence, Italy

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Amedeo Amedei Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Michaela Luconi Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
Istituto Nazionale Biostrutture e Biosistemi (I.N.B.B.), via delle Medaglie D’Oro, Rome, Italy

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for continuous variables. Comparison between two groups of data was accomplished using Student’s t- test for normally distributed variables and Mann–Whitney U test for nonparametric variables or paired Wilcoxon’s signed-rank test. Regarding the

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Susan Richter Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Bei Qiu Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Mirthe Ghering Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Carola Kunath Department of Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Georgiana Constantinescu Department of Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Charlotte Luths Department of Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Christina Pamporaki Department of Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Nicole Bechmann Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Department of Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Leah Meuter Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Aleksandra Kwapiszewska Department of Hypertension, Institute of Cardiology, Warsaw, Poland

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Timo Deutschbein Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Medicover Oldenburg MVZ, Oldenburg, Germany

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Svenja Nölting Medizinische Klinik and Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany
Department for Endocrinology, Diabetology and Clinical Nutrition, UniversitätsSpital Zürich, Zurich, Switzerland

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Mirko Peitzsch Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Mercedes Robledo Hereditary Endocrine Cancer Group, CNIO, Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain

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Aleksander Prejbisz Department of Hypertension, Institute of Cardiology, Warsaw, Poland

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Karel Pacak Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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Volker Gudziol Department of Otorhinolaryngology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Hals-Chirurgie, Plastische Operationen, Städtisches Klinikum Dresden, Akademisches Lehrkrankenhaus der Technischen Universität Dresden, Dresden, Germany

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Henri J L M Timmers Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Graeme Eisenhofer Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Department of Medicine III, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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methoxytyramine (MTY) and normetanephrine (NMN) in patients with and without HNPGLs. (A, B, C, D, E and F) Significance was calculated by Wilcoxon rank-sum test. (G) Plasma MTY was plotted against tumor diameter, and linear regression with 95% CI was fitted

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