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Kate M Warde Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland

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Erik Schoenmakers Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science-University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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Eduardo Ribes Martinez Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland

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Yi Jan Lim Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland

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Maeve Leonard Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland

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Sarah J Lawless Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland

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Paula O’Shea Department of Clinical Biochemistry, Galway University Hospitals, Saolta Hospitals Group, Galway, Ireland

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Krishna V Chatterjee Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science-University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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Mark Gurnell Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science-University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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Constanze Hantel Department of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland
Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany

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Michael Conall Dennedy Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland

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of the ER stress markers CHOP and XBP1 S/U in mitotane-treated H295R across all concentrations, which increased in combination with either LXRα inhibitor ( Fig. 2C ). Figure 2 (A) Graphical representation of percentage AnnexinV positive

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Adam Stenman Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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Samuel Backman Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Klara Johansson Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Johan O Paulsson Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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Peter Stålberg Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Jan Zedenius Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden

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among established genes None SQSTM1-NTRK3 None BRAF V600E NCOA4-RET Constitutional event* CHEK2 p.410fs None None None None Mutational aggregation in primary tumor # XBP1(S) activates chaperone genes Translocation of

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Catherine Zabkiewicz Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Jeyna Resaul Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Rachel Hargest Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Wen Guo Jiang Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Lin Ye Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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, Smad2, Map3k1, Tob1, Ywhag/14-3-3γ, Ywhab/14-3-3β, Smad5, Zfp36, Xbp1, Mapk12 and Snail ( Perdigao-Henriques et al . 2016 ). BMP-2 appears to promote motility and invasiveness of MCF-7 and MDA-MB-231 cells, both in vitro and in vivo ( Clement et

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