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Adriana Albani, Luis Gustavo Perez-Rivas, Sicheng Tang, Julia Simon, Kristin Elisabeth Lucia, Paula Colón-Bolea, Jochen Schopohl, Sigrun Roeber, Michael Buchfelder, Roman Rotermund, Jörg Flitsch, Jun Thorsteinsdottir, Jochen Herms, Günter Stalla, Martin Reincke, and Marily Theodoropoulou

bilateral adrenalectomy ( Ritzel et al. 2013 , Pivonello et al. 2015 , Tritos & Biller 2018 , Feelders et al. 2019 ). The somatostatin analogue pasireotide is the only pituitary-targeting pharmaceutical that is approved for the treatment of

Open access

Thomas Cuny, Caroline Zeiller, Martin Bidlingmaier, Céline Défilles, Catherine Roche, Marie-Pierre Blanchard, Marily Theodoropoulou, Thomas Graillon, Morgane Pertuit, Dominique Figarella-Branger, Alain Enjalbert, Thierry Brue, and Anne Barlier

( Iwama et al. 2014 ). In light of the so-called Nelson’s syndrome secondary to bilateral adrenalectomy and abolition of the cortisol-induced negative feedback, the issue concerning the role of PEG in promoting growth of a residual GH-secreting tumor

Open access

Anna Angelousi, Aimee R Hayes, Eleftherios Chatzellis, Gregory A Kaltsas, and Ashley B Grossman

/or metyrapone. Surgical intervention with bilateral adrenalectomy is another option available to some patients ( Hayes & Grossman 2018 ). However, systemic therapy with tyrosine kinase inhibitors such as vandetanib offers a further management strategy for