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Deborah J Thompson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tracy A O'Mara Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dylan M Glubb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jodie N Painter Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Timothy Cheng Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth Folkerd Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Deborah Doody Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Joe Dennis Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Penelope M Webb Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the Australian National Endometrial Cancer Study Group (ANECS) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Maggie Gorman Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Lynn Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Shirley Hodgson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the National Study of Endometrial Cancer Genetics Group (NSECG) Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kyriaki Michailidou Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jonathan P Tyrer Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mel J Maranian Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Per Hall Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kamila Czene Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hatef Darabi Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jingmei Li Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter A Fasching Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alexander Hein Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias W Beckmann Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Arif B Ekici Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Thilo Dörk Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Peter Hillemanns Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Dürst Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ingo Runnebaum Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hui Zhao Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jeroen Depreeuw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stefanie Schrauwen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Frederic Amant Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ellen L Goode Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Brooke L Fridley Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Sean C Dowdy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stacey J Winham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Helga B Salvesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jone Trovik Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tormund S Njolstad Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Henrica M J Werner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Katie Ashton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tony Proietto Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Geoffrey Otton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Luis Carvajal-Carmona Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Emma Tham Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Tao Liu Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Miriam Mints Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for RENDOCAS Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Rodney J Scott Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mark McEvoy Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John Attia Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Elizabeth G Holliday Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Grant W Montgomery Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nicholas G Martin Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Dale R Nyholt Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anjali K Henders Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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John L Hopper Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Nadia Traficante Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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for the AOCS Group Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Matthias Ruebner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Anthony J Swerdlow Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Barbara Burwinkel Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hermann Brenner Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alfons Meindl Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Hiltrud Brauch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Annika Lindblom Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Diether Lambrechts Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Jenny Chang-Claude Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Fergus J Couch Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Graham G Giles Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Vessela N Kristensen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Angela Cox Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Manjeet K Bolla Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Qin Wang Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Stig E Bojesen Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitul Shah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Robert Luben Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Kay-Tee Khaw Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Paul D P Pharoah Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Alison M Dunning Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Ian Tomlinson Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Mitch Dowsett Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Douglas F Easton Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK
Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Amanda B Spurdle Department of Public Health and Primary Care, Department of Genetics and Computational Biology, Wellcome Trust Centre for Human Genetics, Academic Department of Biochemistry, Department of Clinical Genetics, Department of Oncology, Department of Medical Epidemiology and Biostatistics, Department of Medicine, Department of Gynecology and Obstetrics, Institute of Human Genetics, Gynaecology Research Unit, Clinics of Gynaecology and Obstetrics, Department of Gynaecology, Vesalius Research Center, Laboratory for Translational Genetics, Department of Obstetrics and Gynecology, Department of Health Sciences Research, Department of Biostatistics, Department of Obstetrics and Gynecology, Centre for Cancerbiomarkers, Department of Obstetrics and Gynecology, Hunter Medical Research Institute, Centre for Information Based Medicine, School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, Grupo de investigación Citogenética, Genome Center and Department of Biochemistry and Molecular Medicine, Department of Molecular Medicine and Surgery, Department of Women's and Children's Health, Hunter Area Pathology Service, Centre for Clinical Epidemiology and Biostatistics, Institute of Health and Biomedical Innovation, Centre for Epidemiology and Biostatistics, Peter MacCallum Cancer Center, Division of Genetics and Epidemiology, Division of Breast Cancer Research, Department of Gynecology and Obstetrics, Division of Cancer Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Preventive Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Obstetrics and Gynecology, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, Department of Laboratory Medicine and Pathology, Cancer Epidemiology Centre, Department of Epidemiology and Preventive Medicine, Department of Genetics, The K.G. Jebsen Center for Breast Cancer Research, Department of Clinical Molecular Oncology, Department of Oncology, Faculty of Health and Medical Sciences, Department of Clinical Biochemistry, Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival (CNC), Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UK

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Introduction Established risk factors for endometrial cancer include high BMI ( IARC 2002 ), early menarche, late menopause, nulliparity, estrogen-only hormone replacement therapy (HRT) ( Beral et al . 2005 ) and tamoxifen use ( Cuzick et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0386
Volume/Issue:
Volume 23: Issue 2
Open access
Douglas A Gibson Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Frances Collins Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Fiona L Cousins Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Arantza Esnal Zufiaurre Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Philippa T K Saunders Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Introduction Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common cancer in women in developed countries with incidence increasing in line with rising rates of obesity (reviewed in Onstad et al

Article Type:
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DOI:
https://doi.org/10.1530/ERC-17-0449
Volume/Issue:
Volume 25: Issue 4
Open access
Christine M Friedenreich Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3
Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3
Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Annie R Langley Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Thomas P Speidel Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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David C W Lau Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3
Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Kerry S Courneya Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Ilona Csizmadi Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3
Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3
Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Anthony M Magliocco Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Yutaka Yasui Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Linda S Cook Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3
Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3
Division of Cancer Care, Department of Community Health Sciences, Department of Oncology, Biochemistry and Molecular Biology, Faculty of Physical Education and Recreation, Department of Anatomical Pathology, School of Public Health, Department of Internal Medicine, Alberta Health Services, Department of Population Health Research, 2210-2nd Street SW, Calgary, Alberta, Canada T2C 3S3

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Introduction Endometrial cancer is the most common gynecological malignancy afflicting Canadian women with an estimated 4700 new cases and 750 associated deaths in 2011 (Canadian Cancer Society 2011). Obesity, the strongest risk factor identified to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0211
Volume/Issue:
Volume 19: Issue 6
Open access
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Laure Dossus Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Sabina Rinaldi Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Susen Becker Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Annekatrin Lukanova Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Anne Tjonneland Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Anja Olsen Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Jakob Stegger Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Kim Overvad Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Nathalie Chabbert-Buffet Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Aida Jimenez-Corona Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Francoise Clavel-Chapelon Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Sabine Rohrmann Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Birgit Teucher Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Heiner Boeing Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Madlen Schütze Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Antonia Trichopoulou Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Vassiliki Benetou Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Pagona Lagiou Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Domenico Palli Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Franco Berrino Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Salvatore Panico Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Rosario Tumino Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Carlotta Sacerdote Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Maria-Luisa Redondo Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Noémie Travier Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Maria-Jose Sanchez Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Jone M Altzibar Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Maria-Dolores Chirlaque Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Eva Ardanaz Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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H Bas Bueno-de-Mesquita Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Fränzel J B van Duijnhoven Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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N Charlotte Onland-Moret Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Petra H M Peeters Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Goran Hallmans Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Eva Lundin Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Kay-Tee Khaw Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Nicholas Wareham Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Naomi Allen Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Tim J Key Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Nadia Slimani Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Pierre Hainaut Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Dora Romaguera Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Teresa Norat Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Elio Riboli Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Rudolf Kaaks Division of Cancer Epidemiology, Section of Nutrition and Metabolism, Department of Obstetrics and Gynecology, Institute of Cancer Epidemiology, Department of Cardiology, Department of Epidemiology, Obstetrics and Gynecology Department, Inserm, National Institute of Public Health, Department of Epidemiology, WHO Collaborating Center for Food and Nutrition Policies, Hellenic Health Foundation, Molecular and Nutritional Epidemiology Unit, Epidemiology Unit, Department of Clinical and Experimental Medicine, Cancer Registry and Histopathology Unit, Center for Cancer Prevention (CPO Piedmont), Human Genetic Foundation (Hugef), Public Health and Participation Directorate, Unit of Nutrition, Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Department of Public Health of Guipuzkoa, Department of Epidemiology, Public Health Institute of Navarra, National Institute for Public Health and the Environment (RIVM), Julius Center for Health Sciences and Primary Care, Department of Public Health and Clinical Medicine, Department of Medical Biosciences, Department of Public Health and Primary Care, MRC Epidemiology Unit, Cancer Epidemiology Unit, Section of Mechanisms of Carcinogenesis, Department of Epidemiology and Biostatistics, German Cancer Research Center (DKFZ), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Introduction Excess body weight is one of the strongest risk factors for endometrial cancer and accounts for about 50% of the cases in Europe and in the USA ( International Agency for Research on Cancer (IARC) 2002 , Calle & Kaaks 2004 , World

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-10-0053
Volume/Issue:
Volume 17: Issue 4
Open access
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Naomi E Allen
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Timothy J Key
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Laure Dossus Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Sabina Rinaldi Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Anne Cust Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK
Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Annekatrin Lukanova Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Petra H Peeters Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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N Charlotte Onland-Moret Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Petra H Lahmann Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Franco Berrino Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Salvatore Panico Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Nerea Larrañaga Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Guillem Pera Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Maria-José Tormo Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Maria-José Sánchez Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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J Ramón Quirós Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Eva Ardanaz Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Anne Tjønneland Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Anja Olsen Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Jenny Chang-Claude Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Jakob Linseisen Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Mandy Schulz Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Heiner Boeing Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Eva Lundin Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Domenico Palli Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Kim Overvad Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Françoise Clavel-Chapelon Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Marie-Christine Boutron-Ruault Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Sheila Bingham Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Kay-Tee Khaw Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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H Bas Bueno-de-Mesquita Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Antonia Trichopoulou Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Dimitiros Trichopoulos Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Androniki Naska Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Rosario Tumino Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Elio Riboli Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Rudolf Kaaks Cancer Research UK Epidemiology Unit, Nutrition and Hormones Group, University of Sydney, Julius Center for Health Sciences and Primary Care, Medical Research Council Human Nutrition Research, Epidemiology Unit, Department of Clinical and Experimental Medicine, Public Health Department of Gipuzkoa, Department of Epidemiology, Consejería de Sanidad y Política Social, Andalusian School of Public Health, Public Health & Health Planning Directorate, Instituto de Salud Pública de Navarra, Institute of Cancer Epidemiology, Division of Cancer Epidemiology, German Institute of Human Nutrition, Department of Nutritional Research, Molecular and Nutritional Epidemiology Unit, Department of Clinical Epidemiology, Inserm E3N-EPIC, MRC Dunn Human Nutrition Unit, Clinical Gerontology Unit, National Institute of Public Health and the Environment, Department of Hygiene and Epidemiology, Cancer Registry, Cancer Epidemiology and Prevention, University of Oxford, Oxford, UK

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Introduction Endometrial cancer comprises about 4% of all cancers in women worldwide ( Parkin et al . 2002 ) and is the fourth most common cancer in women in westernized countries ( Parkin et al . 2002 , Bray et al . 2005 ). Obesity is an

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0064
Volume/Issue:
Volume 15: Issue 2
Open access
View license
Victoria Byrd Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Ted Getz Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Roshan Padmanabhan Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hans Arora Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Charis Eng Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Germline PTEN mutations defining PTEN hamartoma tumor syndrome (PHTS) confer heritable predisposition to breast, endometrial, thyroid and other cancers with known age-related risks, but it remains impossible to predict if any individual will develop cancer. In the general population, gut microbial dysbiosis has been linked to cancer, yet is unclear whether these are associated in PHTS patients. In this pilot study, we aimed to characterize microbial composition of stool, urine, and oral wash from 32 PTEN mutation-positive individuals using 16S rRNA gene sequencing. PCoA revealed clustering of the fecal microbiome by cancer history (P = 0.03, R 2 = 0.04). Fecal samples from PHTS cancer patients had relatively more abundant operational taxonomic units (OTUs) from family Rikenellaceae and unclassified members of Clostridia compared to those from non-cancer patients, whereas families Peptostreptococcaceae, Enterobacteriaceae, and Bifidobacteriaceae represented relatively more abundant OTUs among fecal samples from PHTS non-cancer patients. Functional metagenomic prediction revealed enrichment of the folate biosynthesis, genetic information processing and cell growth and death pathways among fecal samples from PHTS cancer patients compared to non-cancer patients. We found no major shifts in overall diversity and no clustering by cancer history among oral wash or urine samples. Our observations suggest the utility of an expanded study to interrogate gut dysbiosis as a potential cancer risk modifier in PHTS patients.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0442
Volume/Issue:
Volume 25: Issue 3
Open access
Frances Collins The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Nozomi Itani The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Arantza Esnal-Zufiaurre The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Douglas A Gibson The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Carol Fitzgerald The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Philippa T K Saunders The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Introduction Endometrial cancer is the most common gynaecological malignancy in the developed world with the majority presenting as abnormal bleeding in post-menopausal women; the incidence of this cancer is increasing in parallel with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0291
Volume/Issue:
Volume 27: Issue 2
Open access
Ying Ni Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Spencer Seballos Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Shireen Ganapathi Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Danielle Gurin Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Benjamin Fletcher Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Joanne Ngeow Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Rebecca Nagy Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Richard T Kloos Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Matthew D Ringel Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Thomas LaFramboise Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Charis Eng Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute
Genomic Medicine Institute, Taussig Cancer Institute, Stanley Shalom Zielony Nursing Institute, Division of Medical Oncology, Divisions of Human Genetics, Endocrinology and Metabolism, Comprehensive Cancer Center, Departments of Genetics and Genome Sciences, Epidemiology and Biostatistics, CASE Comprehensive Cancer Center, Lerner Research Institute

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Along with breast and endometrial cancers, thyroid cancer is a major component cancer in Cowden syndrome (CS). Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. To investigate whether SDHx alterations at both germline and somatic levels occur in apparently sporadic breast cancer and differentiated thyroid cancer (DTC), we analyzed SDHx genes in the following four groups: i) 48 individuals with sporadic invasive breast adenocarcinoma for germline mutation; ii) 48 (expanded to 241) DTC for germline mutation; iii) 37 pairs DTC tumor-normal tissues for germline and somatic mutation and mRNA expression levels; and iv) data from 476 patients in the Cancer Genome Atlas thyroid carcinoma dataset for validation. No germline SDHx variant was found in a pilot series of 48 breast cancer cases. As germline SDHx variants were found in our pilot of 48 thyroid cancer cases, we expanded to three series of DTC comprising a total 754 cases, and found 48 (6%) with germline SDHx variants (P<0.001 compared with 0/350 controls). In 513 tumors, we found 27 (5%) with large somatic duplications within chromosome 1 encompassing SDHC. Both papillary and follicular thyroid tumors showed consistent loss of SDHC/D gene expression (P<0.001), which is associated with earlier disease onset and higher pathological-TNM stage. Therefore, we conclude that both germline and somatic SDHx mutations/variants occur in sporadic DTC but are very rare in sporadic breast cancer, and overall loss of SDHx gene expression is a signature of DTC.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0537
Volume/Issue:
Volume 22: Issue 2
Open access
Fabia De Oliveira Andrade Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Wei Yu Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Xiyuan Zhang Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Elissa Carney Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Rong Hu Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Robert Clarke Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Kevin FitzGerald Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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Leena Hilakivi-Clarke Department of Oncology, Georgetown University, Washington, District of Columbia, USA

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( Pan et al. 2017 ). TAM also has moderate (menopausal-like symptoms) to severe side effects (an increased risk of developing endometrial cancer) ( Bergman et al. 2000 , Jones et al. 2012 ) and compliance is variable with many patients not

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0393
Volume/Issue:
Volume 26: Issue 3
Open access
Adel Mandl Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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James M Welch Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Gayathri Kapoor Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Vaishali I Parekh Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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David S Schrump Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA

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R Taylor Ripley Division of General Thoracic Surgery, Baylor College of Medicine, Houston, Texas, USA

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Mary F Walter NIDDK Clinical Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Jaydira Del Rivero Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA

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Smita Jha Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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William F Simonds Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Robert T Jensen Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Lee S Weinstein Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Jenny E Blau Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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Sunita K Agarwal Metabolic Diseases Branch, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA

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). KSR2 has been reported to play a role in many diseases including early onset obesity, metabolic syndrome, insulin resistance, non-small cell lung cancer, melanoma, endometrial cancer, and invasive ductal carcinoma of the breast. Potential targeted

Article Type:
Letter
DOI:
https://doi.org/10.1530/ERC-21-0226
Volume/Issue:
Volume 28: Issue 11
Open access