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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Department of Oncology, St.Olavs Hospital, Trondheim, Norway
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Department of Clinical Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Introduction High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are defined by the presence of neuroendocrine phenotype and a high proliferation rate (Ki-67 > 20%). The HG NEN entity consists of well
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Introduction High-grade neuroendocrine neoplasms (NENs) constitute a rare disease entity and account for approximately 10% of all NENs. Given their rarity, there is a paucity of prospective data to guide the optimal diagnosis and management of
Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Department of Clinical Science, University of Bergen, Bergen, Norway
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Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
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Department of Medical Radiation Physics, Lund University, Lund, Sweden
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Department of Oncology, St. Olavs Hospital, Trondheim, Norway
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Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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Department of Oncology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark
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Department of Oncology, Haukeland University Hospital, Bergen, Norway
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Introduction Neuroendocrine neoplasms (NENs) constitute ~2% of all malignancies and are frequently located in the gastrointestinal (GI) tract and pancreas. High-grade gastroenteropancreatic (HG-GEP) NENs are among the most aggressive cancers
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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The Samuel Lunenfeld Research Institute, Department of Laboratory Medicine and Pathobiology, Department of Obstetrics and Gynecology, Department of Pathology, Microarray Centre, Mount Sinai Hospital, University of Toronto, 60 Murray Street, PO Box 41, Toronto, Ontario, Canada M5T 3L9
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epithelium (OSE), accumulating evidence provides strong support that high-grade serous adnexal cancer, commonly attributed to an ovarian origin, arises from the distal fallopian tube epithelium (FTE; Colgan et al . 2001 , Piek et al . 2001 , Finch et al
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that KAL1 was differentially expressed according to the grade and type of tumor, showing an upregulation in high-grade primary brain tumors. We also found that anosmin-1 enhanced proliferation and motility of glioblastoma cells in vitro , formed a
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Department of Therapeutic Urologic Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
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examining 354 patients undergoing robot-assisted prostatectomy, they concluded that low FT levels were linked with high-grade prostate cancer. In total, the relationship between prostate cancer risk and absolute androgen concentration remain controversial
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differentiated or high-grade NET were not eligible. Furthermore, patients were ineligible if they had received cytotoxic chemotherapy, immunotherapy, or radiotherapy within 4 weeks prior to randomization, or prior therapy with mammalian target of rapamycin
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Duke Proteomics and Metabolomics Resource, Duke University School of Medicine, Durham, NC, USA
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Clinical Trial Unit, Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden
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seen among high-grade tumors ( Nelson et al. 2013 ). In addition, the concentration of 27HC was found to be higher in ERα-positive breast tumors compared to normal breast tissue, and this was attributed to a corresponding decrease in the expression of
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CEINGE Biotecnologie Avanzate Scarl, Naples, Italy
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et al. 2012 ), we showed that D3 is dramatically downregulated at later phases of tumorigenesis and that the expression of D2 is upregulated in high-grade squamous cell carcinoma. High D2 expression levels have also been found in other advanced
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University of Milan, Milan, Italy
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Liver Surgery, Transplantation and Gastroenterology, University of Milan and Istituto Nazionale Tumori Fondazione IRCCS, ENETS Center of Excellence, Milano, Milan, Italy
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scores for OS have been specifically developed to assess OS in patients with gut NETs ( Modlin et al . 2010 ) or gastrointestinal high-grade, G3 neuroendocrine carcinomas (GI-NECs) ( Lamarca et al . 2017 ), to predict progression-free survival of