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Barbora Bulanova Pekova Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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Vlasta Sykorova Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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Karolina Mastnikova Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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Eliska Vaclavikova Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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Jitka Moravcova Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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Petr Vlcek Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic

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Lucie Lancova Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic

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Petr Lastuvka Departments of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic

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Rami Katra Department of Ear, Nose and Throat, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic

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Petr Bavor Department of Surgery, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic

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Daniela Kodetova Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic

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Martin Chovanec Department of Otorhinolaryngology, 3rd Faculty of Medicine, University Hospital Kralovske Vinohrady, Prague, Czech Republic

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Jana Drozenova Department of Pathology, 3rd Faculty of Medicine, University Hospital Kralovske Vinohrady, Prague, Czech Republic

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Radoslav Matej Department of Pathology, 3rd Faculty of Medicine, University Hospital Kralovske Vinohrady, Prague, Czech Republic

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Jaromir Astl Department of Otorhinolaryngology and Maxillofacial Surgery, 3rd Faculty of Medicine and Military University Hospital, Prague, Czech Republic

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Jiri Hlozek Department of Otorhinolaryngology and Maxillofacial Surgery, 3rd Faculty of Medicine and Military University Hospital, Prague, Czech Republic

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Petr Hrabal Department of Pathology, Military University Hospital, Prague, Czech Republic

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Josef Vcelak Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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Bela Bendlova Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic

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features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas . American Journal of Surgical Pathology 30 216 – 222 . ( https://doi.org/10.1097/01.pas.0000176432.73455.1b ) Arighi E Borrello MG & Sariola H 2005

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G Azizi Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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J M Keller Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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M Lewis Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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K Piper Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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D Puett Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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K M Rivenbark Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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C D Malchoff Wilmington Endocrinology, Wilmington Pathology Associates, Children's Hospital Colorado, Carolina Arthritis, University of Connecticut Health Center, 1717 Shipyard Boulevard, Suite 220, Wilmington, North Carolina 28403, USA

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. This often leads to hypothyroidism due to destruction and eventual fibrous replacement of the parenchymal tissue. The relationship between HT and papillary carcinoma (PC) was first proposed by Dailey et al . (1955) . Since this initial description

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Catherine Ory
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Nicolas Ugolin
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Céline Levalois
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Ludovic Lacroix CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Bernard Caillou CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Jean-Michel Bidart CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Martin Schlumberger CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Ibrahima Diallo CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Florent de Vathaire CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Paul Hofman CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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José Santini CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Bernard Malfoy CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France
CEA, Department of Nuclear Medicine and Endocrine Oncology, Inserm, Institut Gustave Roussy, Université Paris XI, INSERM ERI-21, University of Nice-Sophia Antipolis, Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA Tumour/Tissue Bank of Nice Area, Department of Otorhinolaryngology, Institut Curie, CNRS, Université Paris VI, DSV, IRCM, LCE, BP6, Fontenay-aux-Roses F-92265, France

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Sylvie Chevillard
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to the routine screening of thyroid nodules using neck ultrasound and fine needle biopsy, which permit the detection of small papillary carcinomas that would otherwise have gone undetected ( Leenhardt et al . 2004 , Colonna et al . 2007 ). This

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Toyoshi Endo Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Yamanashi 409-3898, Japan

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Tetsuro Kobayashi Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Yamanashi 409-3898, Japan

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Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children . Cancer Research 57 1690 – 1694 . Ohta K Pang XP Berg L Hershman JM 1997 Growth inhibition

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Roland Pfoh Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3

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Ira Kay Lacdao Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3

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Vivian Saridakis Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3

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), oral squamous cell carcinoma ( Piao et al . 2012 ), and papillary carcinoma ( Wang et al . 2013 ). The overexpression of USP22 is related to poor prognosis and may be used as a biomarker during diagnosis. USP22 has been identified as a cancer stem

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Kathleen A Luckett Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jennifer R Cracchiolo Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Gnana P Krishnamoorthy Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Luis Javier Leandro-Garcia Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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James Nagarajah Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Mahesh Saqcena Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Rona Lester Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Soo Y Im Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Zhen Zhao Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Scott W Lowe Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Elisa de Stanchina Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Eric J Sherman Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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Alan L Ho Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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Steven D Leach Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Jeffrey A Knauf Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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James A Fagin Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Weill-Cornell Medical College, New York, New York, USA

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R Salvatore G Fusco A 2003 BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas . Journal of Clinical Endocrinology and Metabolism 88

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N Burrows School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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J Resch School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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R L Cowen School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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R von Wasielewski School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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C Hoang-Vu School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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C M West School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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K J Williams School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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G Brabant School of Pharmacy and Pharmaceutical Sciences, Department of Endocrinology, Department of Pathology, Experimental and Surgical Oncology, Academic Department of Radiation Oncology, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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expression in melanoma . Cancer Research 67 3177 – 3184 . Lee JH Lee ES Kim YS 2007 Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysis . Cancer 110 38

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Xianhui Ruan Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xianle Shi State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Qiman Dong State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Yang Yu Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xiukun Hou Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Xinhao Song State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Xi Wei Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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Lingyi Chen State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Collaborative Innovation Center for Biotherapy, Tianjin Key Laboratory of Protein Sciences, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, Tianjin, China

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Ming Gao Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

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based on pathological characteristics: papillary carcinoma (PTC), follicular carcinoma (FTC) and anaplastic carcinoma (ATC) ( Cho et al. 2013 ). About 90% of thyroid cancer are well differentiated, while 10% or less are poorly differentiated or

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Dong Wang Departments of, Oncology, Laboratory, Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China

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Jia-Fu Feng Departments of, Oncology, Laboratory, Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China

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Ping Zeng Departments of, Oncology, Laboratory, Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China

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Yun-Hong Yang Departments of, Oncology, Laboratory, Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China

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Jun Luo Departments of, Oncology, Laboratory, Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China

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Yu-Wei Yang Departments of, Oncology, Laboratory, Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China

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Saraymen R Yerer B Demirci H 2010 Increased lipid peroxidation and impaired enzymatic antioxidant defense mechanism in thyroid tissue with multinodular goiter and papillary carcinoma . Clinical Biochemistry 43 650 – 654 . doi:10.1016/j

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Sasha R Howard Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Department of Paediatric Endocrinology, Barts Health NHS Trust, London, UK

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Sarah Freeston Whipps Cross Hospital, Barts Health NHS Trust, London, UK

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Barney Harrison Retired Endocrine Surgeon, Sheffield, UK

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Louise Izatt Department of Clinical and Cancer Genetics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Sonali Natu Department of Pathology, University Hospital of North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, UK

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Kate Newbold Department of Clinical Oncology, Royal Marsden Hospital Foundation Trust, London, UK

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Sabine Pomplun Department of Pathology, University College London Hospital NHS Foundation Trust, London, UK

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Helen A Spoudeas Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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Sophie Wilne Department of Paediatric Oncology, Nottingham University Hospital’s NHS Trust, Nottingham, UK

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Tom R Kurzawinski Department of Endocrine Surgery, University College London Hospitals NHS Foundation Trust, London, UK
Department of Paediatric Endocrine Surgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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Mark N Gaze Department of Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, UK
Department of Clinical Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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–90% of DTCs in children are papillary carcinoma and 5–20% follicular carcinoma ( Hogan et al. 2009 , Papendieck et al. 2011 , Mussa et al. 2013 , De Jong et al. 2021 ). In all age groups in the United Kingdom, overall DTC mortality has

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