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Sara Pusceddu Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

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Francesco Barretta Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy

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Annalisa Trama Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Evaluative Epidemiology Unit, ENETS Center of Excellence, Milan, Italy

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Laura Botta Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Evaluative Epidemiology Unit, ENETS Center of Excellence, Milan, Italy

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Massimo Milione Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, ENETS Center of Excellence, Milan, Italy

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Roberto Buzzoni Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

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Filippo De Braud Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
University of Milan, Milan, Italy

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Vincenzo Mazzaferro University of Milan, Milan, Italy
Liver Surgery, Transplantation and Gastroenterology, University of Milan and Istituto Nazionale Tumori Fondazione IRCCS, ENETS Center of Excellence, Milano, Milan, Italy

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Ugo Pastorino Department of Thoracic Surgical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, ENETS Center of Excellence, Milan, Italy

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Ettore Seregni Department of Nuclear Medicine ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Milan, Italy

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Luigi Mariani Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy

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Gemma Gatta Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Evaluative Epidemiology Unit, ENETS Center of Excellence, Milan, Italy

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Maria Di Bartolomeo Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

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Daniela Femia Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

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Natalie Prinzi Department of Medical Oncology ENETS Center of Excellence, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

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Jorgelina Coppa Liver Surgery, Transplantation and Gastroenterology, University of Milan and Istituto Nazionale Tumori Fondazione IRCCS, ENETS Center of Excellence, Milano, Milan, Italy

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Francesco Panzuto Department of Medical Gastroenterology, Azienda Ospedaliera Sant’Andrea, Roma ENETS Center of Excellence, Rome, Italy

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Lorenzo Antonuzzo Department of Medical Oncology, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy

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Emilio Bajetta Department of Medical Oncology, Policlinico di Monza, Monza, Italy

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Maria Pia Brizzi Department of Medical Oncology, Azienda Ospedaliera Universitaria San Luigi Gonzaga, Orbassano, Italy

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Davide Campana Department of Medical Oncology, Policlinico Sant’Orsola Malpighi, Bologna, Italy

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Laura Catena Department of Medical Oncology, Policlinico di Monza, Monza, Italy

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Harry Comber Ireland National Cancer Registry, Cork, Ireland

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Fiona Dwane Ireland National Cancer Registry, Cork, Ireland

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Nicola Fazio Department of Medical Oncology, IEO – Istituto Europeo di Oncologia, Milano, ENETS Center of Excellence, Milan, Italy

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Antongiulio Faggiano Department of Thyroid and Parathyroid Surgery Unit, Azienda Ospedaliera Universitaria Federico II, ENETS Center of Excellence, Naples, Italy

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Dario Giuffrida Department of Medical Oncology, IOM – Istituto Oncologico del Mediterraneo, Catania, Italy

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Kris Henau Belgian Cancer Registry, Brussels, Belgium

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Toni Ibrahim Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, IRCCS, Meldola, Italy

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Riccardo Marconcini Department of Medical Oncology, Ospedale Santa Chiara, Pisa, Italy

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Sara Massironi Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy

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Maja Primic Žakelj Institute of Oncology Ljubljana, Epidemiology and Cancer Registry, Ljubljana, Slovenia

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Francesca Spada Department of Medical Oncology, IEO – Istituto Europeo di Oncologia, Milano, ENETS Center of Excellence, Milan, Italy

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Salvatore Tafuto Department of Medical Oncology, Fondazione IRCCS Pascale, ENETS Center of Excellence, Naples, Italy

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Elizabeth Van Eycken Belgian Cancer Registry, Brussels, Belgium

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Jan Maaten Van der Zwan Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands

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Tina Žagar Institute of Oncology Ljubljana, Epidemiology and Cancer Registry, Ljubljana, Slovenia

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Luca Giacomelli Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy

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Rosalba Miceli Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy

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NEPscore Working Group
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derived a covariate scoring system based on the 10-year OS predicted by the final Cox model. Then, a three-level prognostic score was derived for classifying patients according to their predicted 10-year OS: (i) favorable risk group: OS ≥70%; (ii

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0489
Volume/Issue:
Volume 25: Issue 6
Open access
Yuet-Kin Leung Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Hung-Ming Lam Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Shulin Wu Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Dan Song Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Linda Levin Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Liang Cheng Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Chin-Lee Wu Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Shuk-Mei Ho Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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cytoplasmic signals of each ERβ isoform were examined separately. Signal intensity and percentage of signal coverage of each region were scored according to the Allred scoring system ( Allred et al . 1993 ). The intensity signal was graded from 0 to 3 (0

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0294
Volume/Issue:
Volume 17: Issue 3
Open access
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Paraskevi Xekouki Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UK

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Emily J Lodge Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Endocrinology and Diabetes, King’s College London, London, UK

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Jakob Matschke Institute of Neuropathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

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Alice Santambrogio Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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John R Apps Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK

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Ariane Sharif Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France

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Thomas S Jacques Birth Defects Research Centre, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK

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Simon Aylwin Department of Endocrinology, King’s College Hospital NHS Foundation Trust, London, UK

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Vincent Prevot Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, Jean-Pierre Aubert Research Centre, Lille, France

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Ran Li Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

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Jörg Flitsch Department of Neurosurgery, Hamburg University Medical Center, Hamburg, Germany

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Stefan R Bornstein Department of Endocrinology and Diabetes, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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Marily Theodoropoulou Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany

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Cynthia L Andoniadou Centre for Craniofacial and Regenerative Biology, King’s College London, London, UK
Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Dresden, Germany

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& Inoshita 2018 ). YAP and TAZ expression was variable and was subdivided into three different groups based on a semiquantitative scoring system as described in the methods ( Fig. 2C , Table 1 ). Four out of ten null-cell tumours displayed high

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0330
Volume/Issue:
Volume 26: Issue 1
Open access
Giulia Cantini Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
Istituto Nazionale Biostrutture e Biosistemi (I.N.B.B.), via delle Medaglie D’Oro, Rome, Italy

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Elena Niccolai Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Letizia Canu Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy

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Leandro Di Gloria Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy

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Simone Baldi Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Arianna Pia Propato Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy

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Laura Fei Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy

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Giulia Nannini Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Soraya Puglisi Department of Clinical and Biological Sciences, Internal Medicine, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy

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Gabriella Nesi Department of Health Sciences, Pathology Section, University of Florence, Florence, Italy

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Matteo Ramazzotti Department of Experimental and Clinical Biomedical Sciences, Biochemical Sciences Section, University of Florence, Florence, Italy

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Amedeo Amedei Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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Michaela Luconi Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy
European Network for the Study of Adrenal Tumors (ENS@T) Center of Excellence, Florence, Italy
Centro di Ricerca e Innovazione sulle Patologie Surrenaliche, AOU Careggi, Florence, Italy
Istituto Nazionale Biostrutture e Biosistemi (I.N.B.B.), via delle Medaglie D’Oro, Rome, Italy

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by mass spectrometry at Careggi University Hospital on blood samples obtained before surgery. Tumour specimens were evaluated according to the Weiss scoring system, in which the presence of three or more criteria highly correlates with malignant

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-23-0094
Volume/Issue:
Volume 30: Issue 10
Open access
N Tufton Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust. West Smithfield, London, UK

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R J Hearnden Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK

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D M Berney Department of Pathology, Royal London Hospital, Whitechapel, London, UK

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W M Drake Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust. West Smithfield, London, UK

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L Parvanta Department of Endocrine Surgery, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, UK

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J P Chapple Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK

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S A Akker Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust. West Smithfield, London, UK

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a larger tumour set, the TME may be an additional factor that could be included in scoring systems such as those most recently proposed ( Wang et al. 2020 , Yamazaki et al. 2020 ) to aid in better stratification of patients at higher risk. As

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0020
Volume/Issue:
Volume 29: Issue 11
Open access
Victoria Byrd Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Ted Getz Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Roshan Padmanabhan Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hans Arora Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Charis Eng Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

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Remzi B Orloff MS , et al . 2011 A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands . American Journal of Human Genetics 88 42 – 56 . ( https

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0442
Volume/Issue:
Volume 25: Issue 3
Open access
Julia Hoefer
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Johann Kern Experimental Urology, Oncotyrol Laboratory for Tumor Biology and Angiogenesis, Institute of Pathology, Division of Molecular Pathophysiology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

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Philipp Ofer
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Iris E Eder
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Georg Schäfer
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Dimo Dietrich Experimental Urology, Oncotyrol Laboratory for Tumor Biology and Angiogenesis, Institute of Pathology, Division of Molecular Pathophysiology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

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Glen Kristiansen Experimental Urology, Oncotyrol Laboratory for Tumor Biology and Angiogenesis, Institute of Pathology, Division of Molecular Pathophysiology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

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Stephan Geley Experimental Urology, Oncotyrol Laboratory for Tumor Biology and Angiogenesis, Institute of Pathology, Division of Molecular Pathophysiology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

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Johannes Rainer Experimental Urology, Oncotyrol Laboratory for Tumor Biology and Angiogenesis, Institute of Pathology, Division of Molecular Pathophysiology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

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Eberhard Gunsilius Experimental Urology, Oncotyrol Laboratory for Tumor Biology and Angiogenesis, Institute of Pathology, Division of Molecular Pathophysiology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria

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Helmut Klocker
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Zoran Culig
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Martin Puhr
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assessed using two TMAs constructed from tissue cores obtained from ten patients with lymph node and bone metastases respectively. Evaluation was done by an uropathologist (G S) using the semi-quantitative scoring system ‘quickscore’ ( Detre et al . 1995

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-13-0446
Volume/Issue:
Volume 21: Issue 2
Open access
Pei-Pei Xu Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Su Zeng Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Xiao-Tian Xia Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Zi-Heng Ye Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Mei-Fang Li Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Ming-Yun Chen Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai, China

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Tian Xia CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

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Jing-Jing Xu Department of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

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Qiong Jiao Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Liang Liu Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Lian-Xi Li Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai, China

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Ming-Gao Guo Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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The expression levels of FAM172A were assessed by IHC analysis. Based on the percentage and intensity of the positively stained tumor cells under microscopy (400×), a semi-quantitative scoring system was applied to assess the staining results ( Bovee

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0181
Volume/Issue:
Volume 27: Issue 11
Open access
Sasha R Howard Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Department of Paediatric Endocrinology, Barts Health NHS Trust, London, UK

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Sarah Freeston Whipps Cross Hospital, Barts Health NHS Trust, London, UK

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Barney Harrison Retired Endocrine Surgeon, Sheffield, UK

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Louise Izatt Department of Clinical and Cancer Genetics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Sonali Natu Department of Pathology, University Hospital of North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, UK

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Kate Newbold Department of Clinical Oncology, Royal Marsden Hospital Foundation Trust, London, UK

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Sabine Pomplun Department of Pathology, University College London Hospital NHS Foundation Trust, London, UK

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Helen A Spoudeas Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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Sophie Wilne Department of Paediatric Oncology, Nottingham University Hospital’s NHS Trust, Nottingham, UK

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Tom R Kurzawinski Department of Endocrine Surgery, University College London Hospitals NHS Foundation Trust, London, UK
Department of Paediatric Endocrine Surgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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Mark N Gaze Department of Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, UK
Department of Clinical Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

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CYP-specific scoring system, the GDG recommends following Royal College of Pathologists guidelines. It is important to note that age is an important predictor of CYP in that most, albeit low quality, studies show that young children have a worse

Article Type:
Other
DOI:
https://doi.org/10.1530/ERC-22-0035
Volume/Issue:
Volume 29: Issue 11
Open access