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). Exosomes are extracellular vesicles (diameter 30–150 nm) secreted by cells with various biological functions ( Mears et al. 2004 , Sharma et al. 2016 ). Their involvement in intercellular communication has been widely depicted by delivering signaling
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Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zürich, Switzerland
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composition of a subset of ACC. Traces of extracellular vesicle-associated microRNAs in the blood was also found to be useful but for a different purpose; perioperative diagnosis of ACC ( Perge et al . 2017 ). Translational research and basic science
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Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
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Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
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IV Geldof AA Lavaei M Piersma SR van Moorselaar RJ Jimenez CR 2013 Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients . Journal of Extracellular
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Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia
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signaling molecules in the cell as well as extracellularly as paracrine or/and endocrine factors. Examples are succinate and lactate; both act through G protein-coupled receptors and regulate inflammatory responses ( Kes et al. 2020 ). The amino acids