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Lei Qiao Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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Chao Dong Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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Wenlei Jia Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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Gang Sun Department of Breast and Thyroid Surgery, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, Xinjiang Uygur Autonomous Region, China

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). Exosomes are extracellular vesicles (diameter 30–150 nm) secreted by cells with various biological functions ( Mears et al. 2004 , Sharma et al. 2016 ). Their involvement in intercellular communication has been widely depicted by delivering signaling

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J Crona Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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F Beuschlein Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zürich, Switzerland

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K Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, Maryland, USA

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B Skogseid Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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composition of a subset of ACC. Traces of extracellular vesicle-associated microRNAs in the blood was also found to be useful but for a different purpose; perioperative diagnosis of ACC ( Perge et al . 2017 ). Translational research and basic science

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Federica Finetti Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Erika Terzuoli Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Antonio Giachetti Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Raffaella Santi Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Donata Villari Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Hiromi Hanaka Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Olof Radmark Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Marina Ziche Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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Sandra Donnini Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
Department of Life Sciences, Department of Surgery and Translational Medicine, Department of Clinical and Experimental Medicine, Department of Medical Biochemistry and Biophysics, Istituto Toscano Tumori (ITT), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

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IV Geldof AA Lavaei M Piersma SR van Moorselaar RJ Jimenez CR 2013 Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients . Journal of Extracellular

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Susan Richter Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse, Dresden, Germany

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Timothy J Garrett Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA

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Nicole Bechmann Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse, Dresden, Germany

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Roderick J Clifton-Bligh Cancer Genetics Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, St Leonards, Australia
Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia

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Hans K Ghayee Department of Internal Medicine, Division of Endocrinology, University of Florida College of Medicine and Malcom Randall VA Medical Center, Gainesville, Florida, USA

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signaling molecules in the cell as well as extracellularly as paracrine or/and endocrine factors. Examples are succinate and lactate; both act through G protein-coupled receptors and regulate inflammatory responses ( Kes et al. 2020 ). The amino acids

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