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Tobias Hofving, Yvonne Arvidsson, Bilal Almobarak, Linda Inge, Roswitha Pfragner, Marta Persson, Göran Stenman, Erik Kristiansson, Viktor Johanson, and Ola Nilsson

the most frequently used PanNET cell lines are QGP-1 and BON-1. QGP-1 was established in 1980 from a somatostatin-producing islet cell carcinoma ( Kaku et al . 1980 , Iguchi et al . 1990 ) and it has been used to study the molecular mechanisms that

Open access

Emanuel Christ, Kwadwo Antwi, Melpomeni Fani, and Damian Wild

-protein-coupled receptor family . Only a single GLP-1R is known so far, which is structurally identical in all tissues ( Thorens et al. 1993 ). The GLP-1R is of clinical interest not only due to its physiologic expression and functions in pancreatic islet cells

Open access

Roland Pfoh, Ira Kay Lacdao, and Vivian Saridakis

Ubiquitination The ubiquitin–proteasome system (UPS) has many critical regulatory roles in eukaryotic cellular processes including cell cycle progression, stress response, signal transduction, transcriptional activation, and DNA repair ( Ciechanover