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Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
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Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
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Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
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Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
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Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
Department of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Division of Endocrine and Metabolic Diseases, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University, 197 Ruijin Er Lu, Shanghai 200025, People's Republic of China
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similar to those detected by CGH analysis. The most obvious was the gain of erythroblastic leukemia viral oncogene homolog 2 ( ERBB-2 ) oncogene located on chromosome 17q that was more common in malignant pheochromocytomas. Moreover, we analyzed the ERBB
Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK
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Department of Endocrinology, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK
Department of Diabetes and Endocrinology, University College London Hospital, London, UK
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.1016/j.ccell.2017.01.009 ) 28196587 10.1016/j.ccell.2017.01.009 Dannenberg H De Krijger RR van der Harst E Abbou M Ijzendoorn Y Komminoth P Dinjens WN 2003 Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas
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Department of Medicine-Solna, Yale Endocrine Neoplasia Laboratory, Department of Surgery, Departments of Oncology-Pathology, Molecular Medicine and Surgery, Department of Pathology, Karolinska Institutet, Karolinska University Hospital CMM, SE-171 76 Stockholm, Sweden
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Department of Medicine-Solna, Yale Endocrine Neoplasia Laboratory, Department of Surgery, Departments of Oncology-Pathology, Molecular Medicine and Surgery, Department of Pathology, Karolinska Institutet, Karolinska University Hospital CMM, SE-171 76 Stockholm, Sweden
Department of Medicine-Solna, Yale Endocrine Neoplasia Laboratory, Department of Surgery, Departments of Oncology-Pathology, Molecular Medicine and Surgery, Department of Pathology, Karolinska Institutet, Karolinska University Hospital CMM, SE-171 76 Stockholm, Sweden
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Department of Medicine-Solna, Yale Endocrine Neoplasia Laboratory, Department of Surgery, Departments of Oncology-Pathology, Molecular Medicine and Surgery, Department of Pathology, Karolinska Institutet, Karolinska University Hospital CMM, SE-171 76 Stockholm, Sweden
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Department of Medicine-Solna, Yale Endocrine Neoplasia Laboratory, Department of Surgery, Departments of Oncology-Pathology, Molecular Medicine and Surgery, Department of Pathology, Karolinska Institutet, Karolinska University Hospital CMM, SE-171 76 Stockholm, Sweden
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Department of Medicine-Solna, Yale Endocrine Neoplasia Laboratory, Department of Surgery, Departments of Oncology-Pathology, Molecular Medicine and Surgery, Department of Pathology, Karolinska Institutet, Karolinska University Hospital CMM, SE-171 76 Stockholm, Sweden
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%) 4/81 (5%) Adrenocortical carcinoma (ACC) 3/27 (11%) 1/7 (14%) 4/34 (12%) Adrenocortical adenoma (ACA) 0/21 0/26 0/47 Pheochromocytoma (PCC) 0/86 1/19 (5%) 1/105 (1%) Malignant PCC a 0/10 – 0/10 Benign PCC 0
Department of Molecular Medicine and Surgery, Cancer Centre Karolinska, Department of Surgery, Department of Oncology–Pathology, Department of Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, SE-171 76 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Cancer Centre Karolinska, Department of Surgery, Department of Oncology–Pathology, Department of Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, SE-171 76 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Cancer Centre Karolinska, Department of Surgery, Department of Oncology–Pathology, Department of Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, SE-171 76 Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Cancer Centre Karolinska, Department of Surgery, Department of Oncology–Pathology, Department of Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, SE-171 76 Stockholm, Sweden
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extended tumor panel of pheochromocytomas and paragangliomas. Notably and as our previous findings indicated a presence of CIMP in strong association with malignant paragangliomas with SDHB mutation ( Geli et al . 2008 , Kiss et al . 2008 ), the
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Babich JW 2009 Radiation dosimetry, pharmacokinetics, and safety of ultratrace iobenguane I-131 in patients with malignant pheochromocytoma/paraganglioma or metastatic carcinoid . Cancer Biotherapy and Radiopharmaceuticals 24 469 – 475 . ( https
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Rieubland C Crespin M Nau V Khau VanKien P Corvol P Plouin PF Jeunemaitre X 2003 Mutations in the SDHB gene are associated with extra-adrenal and/or malignant pheochromocytomas . Cancer Research 63 5615 – 5621 . Gimenez
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Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Oncology Reports 24 89 – 98 . ( https://doi.org/10.1007/s11912-022-01197-0 ) Kim JK Kim BH Baek SM Shin DH Kim WJ Jeon YK Kim SS & Kim IJ 2014 Incidentally detected inoperable malignant pheochromocytoma with hepatic metastasis treated by
Département de Médecine Génomique des Tumeurs et des Cancers, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
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Biomedical Research Networking Centre on Rare Diseases (CIBERER), Institute of Health Carlos III, Madrid, Spain
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Mays Cancer Center at UTHSCSA, San Antonio, Texas, USA
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First International Randomized Study in Malignant Progressive Pheochromocytoma and Paragangliomas (FIRSTMAPPP): an academic double-blind trial investigating sunitinib . Annals of Oncology 32 S621. ( https://doi.org/10.1016/j.annonc.2021.08.702 ) Ben
Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, UK
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, we report a further case of a malignant PGL in a 46-year-old man with a succinate dehydrogenase complex flavoprotein subunit A ( SDHA ) germline mutation (c.91C > T, p.Arg31*). In the case we describe, following the initial surgical removal of a left
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Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia
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regression and stability with treatment ( Joshua et al. 2009 ). Newer data from the First International Randomized Study in Malignant Progressive Pheochromocytoma and Paragangliomas (FIRSTMAPPP, NCT01371201) indicate that 35.9% of patients with progressive