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Frances Collins The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Nozomi Itani The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Arantza Esnal-Zufiaurre The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Douglas A Gibson The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Carol Fitzgerald The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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Philippa T K Saunders The University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, Edinburgh, UK

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changing demographics characterized by an aging population and increased prevalence of obesity ( Sanderson et al. 2017 ). Clinically, endometrial cancers are routinely classified as having a type I or type II phenotype, with the former being oestrogen

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0291
Volume/Issue:
Volume 27: Issue 2
Open access
Felicity E B May Department of Pathology, Faculty of Medical Sciences, Northern Institute for Cancer Research and Newcastle University Institute for Ageing, University of Newcastle‐upon‐Tyne, Framlington Place, Newcastle‐upon‐Tyne NE2 4HH, UK

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Bruce R Westley Department of Pathology, Faculty of Medical Sciences, Northern Institute for Cancer Research and Newcastle University Institute for Ageing, University of Newcastle‐upon‐Tyne, Framlington Place, Newcastle‐upon‐Tyne NE2 4HH, UK

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). Adjuvant endocrine therapy for early breast cancer patients became widespread in the mid to late 1980s ( Davies et al . 2013 ). Two main categories of drugs target the dependence of malignant breast epithelial cells upon oestrogens. Aromatase inhibitors

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-15-0129
Volume/Issue:
Volume 22: Issue 3
Open access
Douglas A Gibson Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Frances Collins Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Fiona L Cousins Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Arantza Esnal Zufiaurre Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Philippa T K Saunders Medical Research Council Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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agonists on the endometrium or endometrial malignancies is not known. In addition to activating LXRs, 27HC can also bind oestrogen receptors (ER) ( Umetani et al . 2007 ) and acts as an endogenous selective oestrogen receptor modulator (SERM) ( DuSell

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-17-0449
Volume/Issue:
Volume 25: Issue 4
Open access
Anastasia Alataki Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital and The Institute of Cancer Research, London, UK
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK

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Mitch Dowsett Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital and The Institute of Cancer Research, London, UK
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK

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Introduction Breast cancer development and progression are significantly affected by signalling pathways involving oestrogen receptor (ER) and growth factor receptors ( Arpino et al. 2008 ). Over 80% of all breast cancer cases are deemed ER

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-21-0293
Volume/Issue:
Volume 29: Issue 8
Open access
Abigail Read The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
Division of Molecular Pathology, The Institute of Cancer Research, London, UK

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Rachael Natrajan The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK
Division of Molecular Pathology, The Institute of Cancer Research, London, UK

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examples of common driver oncogenes and tumour suppressor genes that can be aberrantly spliced in breast cancer. AS has also been shown to regulate protein diversity of the oestrogen receptor itself. In particular, previous studies have shown the ERαΔ5

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-18-0068
Volume/Issue:
Volume 25: Issue 9
Open access
Catherine Zabkiewicz Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Jeyna Resaul Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Rachel Hargest Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Wen Guo Jiang Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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Lin Ye Cardiff China Medical Research Collaborative Cardiff University School of Medicine, Cardiff, UK

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breast cancers ( Cancer Research UK 2017 ). Even for those treated at an early stage, there is still a significant risk of relapse, often several years later. This is particularly true of oestrogen receptor-positive breast cancers, which are at a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0139
Volume/Issue:
Volume 24: Issue 10
Open access
Yuet-Kin Leung Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Hung-Ming Lam Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Shulin Wu Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Dan Song Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Linda Levin Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Liang Cheng Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Chin-Lee Wu Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Shuk-Mei Ho Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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. Henderson BE Bernstein L Ross RK Depue RH Judd HL 1988 The early in utero oestrogen and testosterone environment of blacks and whites: potential effects on male offspring . British Journal of Cancer 57 216 – 218 . Ho SM Leung YK

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0294
Volume/Issue:
Volume 17: Issue 3
Open access
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Andrew M K Law Tumour Development Group, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Cancer Biology Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Elgene Lim Connie Johnson Breast Cancer Research Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia

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Christopher J Ormandy Cancer Biology Laboratory, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia

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David Gallego-Ortega Tumour Development Group, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Australia, Sydney, New South Wales, Australia

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). These processes are tightly controlled by hormones. Oestrogens, progesterone and prolactin act on the mammary epithelium in synergy with corticosteroids and growth hormone to orchestrate mammary gland development ( Brisken & O’Malley 2010 , Macias

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0404
Volume/Issue:
Volume 24: Issue 4
Open access
D Alwyn Dart
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Bradley Spencer-Dene Androgen Signalling Laboratory, Department of Histopathology, Department of Oncology, Imperial College London, Du Cane Road, London W12 0NN, UK

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Simon C Gamble
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Jonathan Waxman
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Charlotte L Bevan
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), presumably enabling androgen-stimulated cell cycle entry and growth. More recently, PHB has been shown to be a corepressor of the oestrogen receptor (ERα; He et al . 2008 ), associating with oestrogen-regulated promoters in the absence of hormone and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-09-0028
Volume/Issue:
Volume 16: Issue 4
Open access
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Philipp Y Maximov Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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Balkees Abderrahman Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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Ramona F Curpan Institute of Chemistry, Romanian Academy, Timisoara, Romania

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Yousef M Hawsawi Department of Genetics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

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Ping Fan Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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V Craig Jordan Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA

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Society with Dr Jordan’s selection as the 2018 Endocrine Society Laureate of the Gerald D Aurbach Award for Outstanding Translational Research. References Abderrahman B Jordan VC 2016 Improving long-term adjuvant anti-oestrogenic therapy

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0416
Volume/Issue:
Volume 25: Issue 2
Open access