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Varinder Jeet
Varinder Jeet
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Gregor Tevz
Gregor Tevz
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Melanie Lehman
Melanie Lehman
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Brett Hollier
Brett Hollier
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Colleen Nelson
Colleen Nelson
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Australian Prostate Cancer Research Centre – Queensland, Department of Urologic Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Australia
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Introduction Each year, more than 258 000 men will die of prostate cancer (PCa), making PCa the second largest cause of cancer-related mortality in males globally ( Jemal et al . 2011 , Siegel et al . 2012 ). While early-stage PCa can be
J T W Kwon
J T W Kwon
Department of Oncology, University of Oxford, Oxford, UK
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R J Bryant
R J Bryant
Department of Oncology, University of Oxford, Oxford, UK
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
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Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
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E E Parkes
E E Parkes
Department of Oncology, University of Oxford, Oxford, UK
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Introduction Prostate cancer (PCa) is the second most commonly diagnosed cancer and the fifth most common cause of death in men worldwide ( Sung et al. 2021 ). Although the aetiology of PCa is multifactorial, genomics is a key variable
Simon Linder
Simon Linder
Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Henk G van der Poel
Henk G van der Poel
Division of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Andries M Bergman
Andries M Bergman
Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Wilbert Zwart
Wilbert Zwart
Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
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Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
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Stefan Prekovic
Stefan Prekovic
Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Introduction Ever since the discovery that prostate cancer (PCa) growth after androgen deprivation therapy (ADT) remains dependent on androgen receptor (AR) signaling, researchers have been looking for new effective ways to block the action of
Philipp Y Maximov
Philipp Y Maximov
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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Balkees Abderrahman
Balkees Abderrahman
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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Ramona F Curpan
Ramona F Curpan
Institute of Chemistry, Romanian Academy, Timisoara, Romania
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Yousef M Hawsawi
Yousef M Hawsawi
Department of Genetics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
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Ping Fan
Ping Fan
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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V Craig Jordan
V Craig Jordan
Department of Breast Medical Oncology, MD Anderson Cancer Centre, Houston, Texas, USA
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Introduction Despite advances in understanding the molecular biology of prostate and breast cancers, they are still the most frequently diagnosed cancers in men and women, in the United States. There is no completely effective preventative for
Parvin Yenki
Parvin Yenki
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Satyam Bhasin
Satyam Bhasin
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Liang Liu
Liang Liu
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Noushin Nabavi
Noushin Nabavi
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Chi Wing Cheng
Chi Wing Cheng
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Kevin J Tam
Kevin J Tam
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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James W Peacock
James W Peacock
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Hans H Adomat
Hans H Adomat
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Tabitha Tombe
Tabitha Tombe
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Ladan Fazli
Ladan Fazli
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Larissa Ivanova
Larissa Ivanova
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Christopher Dusek
Christopher Dusek
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Shahram Khosravi
Shahram Khosravi
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Emma S Tomlinson Guns
Emma S Tomlinson Guns
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
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Yuzhuo Wang
Yuzhuo Wang
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Ralph Buttyan
Ralph Buttyan
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Martin E Gleave
Martin E Gleave
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Christopher J Ong
Christopher J Ong
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Introduction Despite its initial efficacy, androgen deprivation therapy (ADT) remains a palliative treatment for metastatic prostate cancer, and patients eventually progress to castration-resistant prostate cancer (CRPC) ( So et al. 2005
Konsta Kukkonen
Konsta Kukkonen
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
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Bryn Autio-Kimura
Bryn Autio-Kimura
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
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Hanna Rauhala
Hanna Rauhala
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
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Juha Kesseli
Juha Kesseli
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
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Matti Nykter
Matti Nykter
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Foundation for the Finnish Cancer Institute, Helsinki, Finland
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Foundation for the Finnish Cancer Institute, Helsinki, Finland
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Leena Latonen
Leena Latonen
Foundation for the Finnish Cancer Institute, Helsinki, Finland
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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Tapio Visakorpi
Tapio Visakorpi
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland
Fimlab Laboratories Ltd, Tampere, Finland
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Fimlab Laboratories Ltd, Tampere, Finland
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Introduction Prostate cancer (PCa) is a major cause of morbidity and mortality in the Western world ( Ferlay et al. 2019 ). With the aging of the population, the incidence of PCa is on the rise, increasing the burden on the health care
Su Jung Oh
Su Jung Oh
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Holger H H Erb
Holger H H Erb
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Alfred Hobisch
Alfred Hobisch
Division of Experimental Urology, Department of Urology, Department of Urology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
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Frédéric R Santer
Frédéric R Santer
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Zoran Culig
Zoran Culig
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Introduction Prostate cancer is the most common malignancy in Western countries and the second leading cause of cancer-related deaths in males ( Jemal et al . 2010 ). Patients diagnosed with localized disease can be cured by either surgery or
Jan Kroon
Jan Kroon
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Martin Puhr
Martin Puhr
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Jeroen T Buijs
Jeroen T Buijs
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Geertje van der Horst
Geertje van der Horst
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Daniëlle M Hemmer
Daniëlle M Hemmer
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Koen A Marijt
Koen A Marijt
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Ming S Hwang
Ming S Hwang
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Motasim Masood
Motasim Masood
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Stefan Grimm
Stefan Grimm
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Gert Storm
Gert Storm
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Josbert M Metselaar
Josbert M Metselaar
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Onno C Meijer
Onno C Meijer
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Zoran Culig
Zoran Culig
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Gabri van der Pluijm
Gabri van der Pluijm
Department of Urology, Department of Targeted Therapeutics, Department of Urology, Department of Clinical Oncology, Division of Experimental Medicine, Department of Pharmaceutics, Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
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Introduction Resistance to chemotherapy is a major hurdle in prostate cancer (PCa) treatment. Although chemotherapeutic treatments typically display initial benefit, cancer cells frequently acquire novel characteristics that will render these cells
Ville Paakinaho
Ville Paakinaho
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
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Jorma J Palvimo
Jorma J Palvimo
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
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composition, they can function either as oncogenes or tumor suppressors ( Holbeck et al. 2010 , Dhiman et al. 2018 ). A subfamily of the NRs, steroid receptors (SRs) are particularly associated with breast cancer (BCa) and prostate cancer (PCa); these are
Mina Sattari
Mina Sattari
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
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Annika Kohvakka
Annika Kohvakka
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
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Elaheh Moradi
Elaheh Moradi
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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Hanna Rauhala
Hanna Rauhala
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
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Henna Urhonen
Henna Urhonen
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
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William B Isaacs
William B Isaacs
The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
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Matti Nykter
Matti Nykter
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
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Teemu J Murtola
Teemu J Murtola
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
Department of Urology, Tampere University Hospital, Tampere, Finland
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Department of Urology, Tampere University Hospital, Tampere, Finland
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Teuvo L J Tammela
Teuvo L J Tammela
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
Department of Urology, Tampere University Hospital, Tampere, Finland
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Department of Urology, Tampere University Hospital, Tampere, Finland
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Leena Latonen
Leena Latonen
Foundation for the Finnish Cancer Institute, Helsinki, Finland
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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G Steven Bova
G Steven Bova
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
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Juha Kesseli
Juha Kesseli
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
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Tapio Visakorpi
Tapio Visakorpi
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland
Fimlab Laboratories Ltd, Tampere University Hospital, Tampere, Finland
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Fimlab Laboratories Ltd, Tampere University Hospital, Tampere, Finland
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Introduction Prostate cancer (PCa) is one of the most common cancers in men. Localized PCa is curable by radiation therapy or surgery. For advanced disease, androgen deprivation therapy (ADT) has been the golden standard treatment for more
