Search Results
You are looking at 1 - 1 of 1 items for
- Author: Greg Kelly x
- Refine by access: Content accessible to me x
Search for other papers by Eva Baxter in
Google Scholar
PubMed
Search for other papers by Karolina Windloch in
Google Scholar
PubMed
Search for other papers by Greg Kelly in
Google Scholar
PubMed
Search for other papers by Jason S Lee in
Google Scholar
PubMed
Search for other papers by Frank Gannon in
Google Scholar
PubMed
Cancer Biology and Therapeutics Laboratory, UCD Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland
Search for other papers by Donal J Brennan in
Google Scholar
PubMed
Up to 80% of endometrial and breast cancers express oestrogen receptor alpha (ERα). Unlike breast cancer, anti-oestrogen therapy has had limited success in endometrial cancer, raising the possibility that oestrogen has different effects in both cancers. We investigated the role of oestrogen in endometrial and breast cancers using data from The Cancer Genome Atlas (TCGA) in conjunction with cell line studies. Using phosphorylation of ERα (ERα-pSer118) as a marker of transcriptional activation of ERα in TCGA datasets, we found that genes associated with ERα-pSer118 were predominantly unique between tumour types and have distinct regulators. We present data on the alternative and novel roles played by SMAD3, CREB-pSer133 and particularly XBP1 in oestrogen signalling in endometrial and breast cancer.
