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Salma Ben-Salem Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Varadha Balaji Venkadakrishnan Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Hannelore V Heemers Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

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Introduction Prostate cancer (CaP) remains the second leading cause of cancer deaths in Western men ( Siegel et al. 2020 ). These deaths occur because of acquired resistance to the systemic therapies for metastatic CaP. Because of CaP

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Kristina V Wells Department of Anatomy, Physiology, and Cell Biology, University of California Davis School of Veterinary Medicine, Davis, California, USA

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Margaret L Krackeler Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, California, USA

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Maitreyee K Jathal Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, USA
Veterans Affairs-Northern California Health System, Mather, California, USA

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Mamta Parikh Division of Hematology and Oncology, School of Medicine, University of California Davis, Sacramento, California, USA

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Paramita M Ghosh Veterans Affairs-Northern California Health System, Mather, California, USA
Department of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, California, USA

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J Kent Leach Department of Orthopaedic Surgery, School of Medicine, University of California Davis, Sacramento, California, USA
Department of Biomedical Engineering, University of California Davis, Davis, California, USA

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Damian C Genetos Department of Anatomy, Physiology, and Cell Biology, University of California Davis School of Veterinary Medicine, Davis, California, USA

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Introduction Prostate cancer (PCa) is a highly prevalent health problem in the developed world. As an age-related disease that is exacerbated by Western diets and lifestyles, the global burden of PCa will only continue to rise as lifespans

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Fritz H Schröder Erasmus MC, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands

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Introduction Endocrine treatment (ET) of prostate cancer (PC) is more than 60 years old ( Huggins & Hodges 1941 , Huggins et al. 1941 ). Huggins and coworkers were awarded the Nobel Prize in 1966 for their studies in endocrine

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Rana P Singh
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Rajesh Agarwal
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Introduction Prostate cancer (PCa) is a chronic disease, and therefore, its chemoprevention is emerging as an attractive additional strategy for disease control. In recent years, considerable progress has been made in this direction

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Benjamin C Thomas Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Jonathan D Kay Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK

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Suraj Menon Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK

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Sarah L Vowler Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Astra Zeneca, 2 Riverside, Granta Park, Cambridge, UK

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Sarah N Dawson Bioinformatics and Statistics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Laura J Bucklow Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Hayley J Luxton Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK

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Thomas Johnston Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Charlie E Massie Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular and Computational Diagnostics Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Michelle Pugh Genomics Core Facility, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Anne Y Warren Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Peter Barker National Institute for Health Research Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Keith Burling National Institute for Health Research Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

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Andy G Lynch Computational Biology Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Anne George Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Johanna Burge Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Marie Corcoran Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Sara Stearn Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Alastair D Lamb Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Naomi L Sharma Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK

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Greg L Shaw Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
University College Hospital at Westmoreland Street, London, UK

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David E Neal Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Headington, Oxford, UK

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Hayley C Whitaker Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Biomarker Initiative, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK
Molecular Diagnostics and Therapeutics Group, University College London, London, UK

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Introduction Prostate cancer is the leading cause of cancer death in men ( Office for National Statistics 2013 ). Prostate cancer growth relies upon androgens, such as testosterone, binding to the androgen receptor (AR) and promoting AR

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Karin Jennbacken Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Tajana Tešan Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Wanzhong Wang Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Heléne Gustavsson Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Jan-Erik Damber Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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Karin Welén Lundberg Laboratory for Cancer Research, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gula Stråket 8, SE-413 45 Göteborg, Sweden

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importance for metastasis of prostate cancer ( Xie et al . 2010 ). In contrast to N-cadherin, E-cadherin mediates homotypic interactions between cells, which maintain the integrity of epithelial tissues ( Giehl & Menke 2008 ). Functional studies show that N

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S Darby
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J Stockley
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M M Khan
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C N Robson
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H Y Leung
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V J Gnanapragasam
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Introduction Prostate cancer remains the most commonly diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA ( Jemal et al. 2006 ). Gonadotrophin-releasing hormone I (GnRH I) analogue

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Vijay K Gonugunta
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Lu Miao
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Gangadhara R Sareddy Department of Urology UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USA

Department of Obstetrics and Gynecology UT Health Science Center, San Antonio, Texas, USA

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Preethi Ravindranathan
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Ratna Vadlamudi Department of Urology UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard J8130, Dallas, Texas 75390, USA

Department of Obstetrics and Gynecology UT Health Science Center, San Antonio, Texas, USA

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Ganesh V Raj
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2007 , Girard et al . 2013 ). This review focuses on the structure, function, and genomic and extranuclear signaling of PELP1, associated signaling pathways, and its role as a target for therapeutic modulation in breast and prostate cancers. PELP1

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Parvin Yenki The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Satyam Bhasin The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Liang Liu The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Noushin Nabavi The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Chi Wing Cheng The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Kevin J Tam The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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James W Peacock The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Hans H Adomat The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Tabitha Tombe The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Ladan Fazli The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Larissa Ivanova The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Christopher Dusek The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Shahram Khosravi The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Emma S Tomlinson Guns The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Yuzhuo Wang The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Ralph Buttyan The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Martin E Gleave The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Christopher J Ong The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Introduction Despite its initial efficacy, androgen deprivation therapy (ADT) remains a palliative treatment for metastatic prostate cancer, and patients eventually progress to castration-resistant prostate cancer (CRPC) ( So et al. 2005

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Penelope D Ottewell Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division

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Ning Wang Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division

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Joshua Meek Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division

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C Anne Fowles Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division

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Peter I Croucher Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division

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Colby L Eaton Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division

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Ingunn Holen Academic Unit of Clinical Oncology, Department of Oncology, Bone Biology, Department of Human Metabolism, Medical School, University of Sheffield, Musculoskeletal Medicine Division

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Introduction Prostate cancer is the most common malignancy and the second most common cause of cancer death in men. In the USA, there were ∼238 590 new prostate cancer diagnoses and more than 29 720 deaths in 2013 ( American Society for Cancer 2013

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