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Frank Claessens
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Wayne Tilley Molecular Endocrinology Laboratory Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, Campus GHB ON1, PO Box 901, 3000 Leuven, Belgium

Dame Roma Mitchell Cancer Research Laboratories School of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia

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of androgen receptor signalling in breast cancer . Endocrine-Related Cancer 21 T161 – T181 . ( doi:10.1530/ERC-14-0243 ). Nelson AW Tilley WD Neal DE Carroll JS 2014 Oestrogen receptor β in prostate cancer: friend or foe? Endocrine

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Balaji Ramachandran Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9 I-20123 Milan, Italy

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Alessia Stell Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9 I-20123 Milan, Italy

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Luca Maravigna Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9 I-20123 Milan, Italy

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Adriana Maggi Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9 I-20123 Milan, Italy

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Paolo Ciana Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9 I-20123 Milan, Italy

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cell functions. Dysregulation of sex hormone-receptor signalling occurs in the tumourigenesis of breast, endometrial, ovary, prostate and testis, where oestrogens, progestin and androgens have been shown to modulate the proliferation of epithelial cells

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Yuet-Kin Leung Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Hung-Ming Lam Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Shulin Wu Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Dan Song Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Linda Levin Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Liang Cheng Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Chin-Lee Wu Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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Shuk-Mei Ho Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health
Division of Environmental Genetics and Molecular Toxicology, Division of Epidemiology and Biostatistics, Center for Environmental Genetics, Cancer Center, Department of Pathology, Department of Pathology and Laboratory Medicine, Department of Environmental Health

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. Henderson BE Bernstein L Ross RK Depue RH Judd HL 1988 The early in utero oestrogen and testosterone environment of blacks and whites: potential effects on male offspring . British Journal of Cancer 57 216 – 218 . Ho SM Leung YK

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Carmela Ricciardelli Discipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia

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project that examined the role of oestrogen in the normal development of the prostate gland and found that oestrogen receptor was expressed by the stromal cells ( Tilley et al . 1989 ). I will always be indebted to Wayne Tilley for giving me the

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A E Wakeling Cancer & Infection Research, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

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phosphorylation of EGFR and ERK1/2 and of the proliferative marker Ki67 ( Gee et al. 2004 ). These clinical observations were anticipated by studies with oestrogen receptor-positive (ER + ) MCF7 human breast cancer cells which showed that resistance to

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Vera Cappelletti
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Luigi Celio
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Emilio Bajetta
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Arianna Allevi
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Raffaella Longarini
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Patrizia Miodini
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Raffaella Villa
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Alessandra Fabbri
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Luigi Mariani
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Riccardo Giovanazzi
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Emanuele Galante
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Marco Greco
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Maria Grazia Daidone
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Breast Cancer. Journal of the National Cancer Institute 90 1601 –1608. Green S , Walter P, Kumar V, Krust A, Bornert JM, Argos P & Chambon P 1986 Human oestrogen receptor sDNA: sequence, expression and homology to v

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Carlo Saccardi
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Salvatore Gizzo
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Tito Silvio Patrelli Department of Woman and Child Health, Department of Surgical Sciences, U.O.C. di Ginecologia e Ostetricia, University of Padua, Via Giustiniani 3, 35128 Padua, Italy

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Emanuele Ancona
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Omar Anis
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Stefania Di Gangi
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Antonio Vacilotto
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Donato D'Antona
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Giovanni Battista Nardelli
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death ranging from 8 to 28%, depending on the type and duration of therapy, the age of the patient and the characteristics of the tumour ( Aebi et al . 2011 ). Tumours with detectable (≥1%) expression of oestrogen receptors (ER) and/or progesterone

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Flavia Magri
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Valentina Capelli
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Mario Rotondi
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Paola Leporati
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Luigi La Manna Units of Internal Medicine and Endocrinology, Laboratorio di Informatica e Sistemistica per la Ricerca Clinica, Laboratorio di Informatica Biomedica, Units of Pathology and Cytology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, 27100 Pavia, Italy

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Rubina Ruggiero Units of Internal Medicine and Endocrinology, Laboratorio di Informatica e Sistemistica per la Ricerca Clinica, Laboratorio di Informatica Biomedica, Units of Pathology and Cytology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, 27100 Pavia, Italy

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Alberto Malovini Units of Internal Medicine and Endocrinology, Laboratorio di Informatica e Sistemistica per la Ricerca Clinica, Laboratorio di Informatica Biomedica, Units of Pathology and Cytology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, 27100 Pavia, Italy

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Riccardo Bellazzi Units of Internal Medicine and Endocrinology, Laboratorio di Informatica e Sistemistica per la Ricerca Clinica, Laboratorio di Informatica Biomedica, Units of Pathology and Cytology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, 27100 Pavia, Italy

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Laura Villani Units of Internal Medicine and Endocrinology, Laboratorio di Informatica e Sistemistica per la Ricerca Clinica, Laboratorio di Informatica Biomedica, Units of Pathology and Cytology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, 27100 Pavia, Italy

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Luca Chiovato
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Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications . Journal of Clinical Pathology 62 6 – 12 . doi:10.1136/jcp.2008.059899 . Banu KS Govindarajulu P Aruldhas MM 2001 Testosterone and

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Ewan M Stephenson Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore

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Laura E J Usselmann Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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Vinay Tergaonkar Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research, Singapore

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David M Virshup Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore

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Robert Dallmann Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK

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This intricate system, and disruptions therein, can have profound effects on human health ( Roenneberg & Merrow 2016 ). Circadian rhythms influence homeostasis and regulate a variety of integral hormones including insulin, glucagon, oestrogen and

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V Craig Jordan Departments of Oncology and Pharmacology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA

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Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial . Lancet Oncology 13 476 – 486 . ( doi:10.1016/S1470

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